J - guts

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Do you support your gut-symbiosis emphasis mostly from observing the

circumstances/course of human illness as reported in patient

testimony online?

Have you seen this one?

Arthritis Rheum. 2000 Nov;43(11):2583-9. Related Articles, Links

Oral antibiotics as a novel therapy for arthritis: evidence for a

beneficial effect of intestinal Escherichia coli.

Nieuwenhuis EE, Visser MR, Kavelaars A, Cobelens PM, Fleer A, Harmsen

W, Verhoef J, Akkermans LM, Heijnen CJ.

Wilhelmina Children's Hospital, Utrecht, The Netherlands.

OBJECTIVE: The intestinal flora is thought to play an important role

in regulation of immune responses. We investigated the effects of

changing the intestinal flora on the course of adjuvant-induced

arthritis (AIA) and on experimental autoimmune encephalomyelitis

(EAE) by the use of oral antibiotics. METHODS: Oral treatment with

either vancomycin or vancomycin, tobramycin, and colistin was started

after AIA and EAE induction. Clinical symptoms of AIA and EAE were

monitored, and microbial analysis of ileal samples was performed.

RESULTS: Oral vancomycin treatment after disease induction

significantly decreased clinical symptoms of AIA. Simultaneously,

increased concentrations of Escherichia coli were detected in the

distal ileum of vancomycin-treated rats. Ileal concentrations of E

coli were inversely related to disease scores in rats with AIA.

Coadministration of colistin/tobramycin to prevent the increase in E

coli abrogated the beneficial effect of vancomycin on AIA. Vancomycin

treatment also reduced the clinical symptoms of EAE. CONCLUSION: We

propose oral vancomycin as a novel therapeutic strategy in autoimmune

diseases.

PMID: 11083284 [PubMed - indexed for MEDLINE]