squooshing our gross lil enemies

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EuroLyme/message/30607

is a summary of what I've been looking into lately re efflux as a

determinant in naturally-abx-resistant infections (including some

concepts Matt pointed out). And of the severe theoretic problems this

theory presents, tho on the whole it remains rather attractive to my

addled little brain.

PMID 15914491, beginning on page 33, contains some fascinating clues

re what I am focusing on right now, which is possible justifications

for the existence of extremely robust nonspecific efflux in only some

bacteria, and only in certain situations (for instance, Bb in vivo vs

in vitro).

Specially interesting is the ref to PMID 11158756 in which hi-efflux

pseudomonads were selected during *untreated* rat infection. This

excites me even tho the phenomenon seen here is probably not remotely

as robust as what would be required for an analogous model of eg poor

treatability of borreliosis despite the ease of killing Bb in vitro.

Perhaps host CAMP could have a role in such selection.

If anyone has any ideas on this, lets jam dude.

Ultimately if this is in fact actually whats going on (maybe / maybe

not), it might be possible to advance treatment of this

(probable/apparant) class of diseases by using drugs to target efflux

pumps (about a billion years from now). And there may be some real

difficulties there.