Re: ARTEMOS /Doxy therapy

[Guest guest]

Jen:

Without a spleen, it takes 30 days to clear the dead (malaria)

parasites from the body and repair the RBCs after treatment with b-

artemether and an abx (RIAMET). In a person with a normal spleen and

uncomplicated malaria it takes about 4 days... and the spleen is

crankin'.

It was very dangerous for me to do this therapy without a spleen.

My 2 Drs. (not LLMDs) were saying omygod if you get into trouble

we're not going to know what to do. My will was in order- I did my

homework- I'd been sick for 20+ years- I was ready. And I'm not

being flip when I say that.

Literature stated there was a 5% death rate for the people withOUT a

spleen when used on COMPLICATED malaria but only 1% death rate for

people with UNcomplicated malaria.. so I took the risk.

COART, ARTEMOS and RIAMET are used throughout the 3rd world, and

there's plenty of data (including death data) out there and I think I

read them all.

If your symptoms don't have you in bed - your % infection is

probably under 1% (I figured mine was well under 1% when I did the

therapy - based on my blood profile- which didn't show any damaged

RBCs- schiztocyts, helmut cells and target cells. But had plenty of

these damaged RBCs in the past during some sort of flare.

-and I tested negative on a Babesia smear from Focus technologies

just before my therapy.

My 2 Drs. really really wanted a positive smear - because they said

that would be 'proof' of chronic babs in a person with asplenia as I

perviously for years had documented periodic bouts of severe RBC

destruction, anemia, fever, sweats basically the right RBC profile

for Babs (or Malaria).. but withOUT the PHYSICAL proof of a parasite

found in the RBC - everything was speculative- even in light of a

positive western blot. I had been previously Mis Dx'd with

autoimmune heymolytic anemia because of the blood profile and a

previous Lupus dx ..

Personally- I would have really worried way more if my smear was

positive - because that would have meant a high % infection - and I

would have really been at risk while my body tried to clear the

damaged RBCs.

b-artemether kills within 45 minutes of ingesting the drug - so

efficacy is very high- it's the repair and clearance of the RBCs

after the kill where a person without a spleen can get into trouble.

I'll tell yah - an autoimmune dx is like the kiss of death - they

NEVER looked beyond that..so they bascially documented me & would

then dx yet another auto-immune disorder every 5 years or so. Auto

immune heymolytic anemia was really a RBC parasite.

On the Artemos/Doxy therapy, I expected spikes of fever - but

instead got 3 bouts of what was very close to hypothermic shock

(severe drop in temp, low HR, Low BP- sleepy-ness each episode

spaced about 50 hrs appart) My Dr. drew blood every 3 times over a 2

week period looking for a change (although did not do a RBC

morphology- mainly because he forgot and I was too tired to remember

myself) and I had quite a spike of eosinophils- which was expected

with parsite clearance,. My Dr. secuplated that I had the opposite of

fever, because of the lack of a spleen - which is what repairs or

discards the damaged RBCs as the parasites exit.

Like I've said before- after reading the Veterinary literature about

cattle with asplenia and Babs- I worried more about Babs killing me

than Lyme, especially as I aged.

Barb

> > More things I read:

> >

> > immunopathophysiology of B bovis and P falciparum infections

> > ig wright bv goodger ia clark

> >

> > immune evasion by B bovis and P falciparum: cliff dwellers of the

> > parasite world

> > dr allred

[Guest guest]

Barb

You really sound like someone that was born suffering mild symptoms

of inflammation ilness till you grew up and got it to full blown

status. Did your mother suffer some form of inflammatory ilness? or

where you born late in her life?

I tend to think leaving childbirth to later years carries all the

risks of undiagnosed infections retarding the full development and

health of a child.Unfortuantely things in the autoimmune deaprtment

often don't manifest until later in life.

> > > More things I read:

> > >

> > > immunopathophysiology of B bovis and P falciparum infections

> > > ig wright bv goodger ia clark

> > >

> > > immune evasion by B bovis and P falciparum: cliff dwellers of

the

> > > parasite world

> > > dr allred

[Guest guest]

Barb, I recall that you said you may have some splenic tissue

somewhere in the body?

Riamet is not arthemos plus abx, its arthemos plus an antimalarial

that is in the larium family. Thats why I'm a little worried, unlike

doxycycline, larium and its kin are known to have lots of side

effects even in those who are not drug sensitive (like moi). I took

1/4 capsule of artemisnin from ARG last night--got headache and achy

liver. OTOH, the reasoning for it is really good, as arthemos and

all artemisinin derivatives have a short half life (3-4 hours), and

this has a long half life (3-4 days). In fact, I was wondering if

anybody JUST taking artemisinin twice a day is only getting peak

blood levels for an hour or two, and allowing the parasites to grow

back in between.

I think you're right--Krause said you can have half a percent

infestation in the blood...and a doctor friend of mine who has lyme

nad babs says even 1-2% infection will make you feel like crap and

feel very sick.

However apparently the bone marrow CAN be much higher infection rate.

Barb, I agree autoimmune diagnosis is the kiss of death, but even

without such a diagnosis I couldn't get tested for babesia when I

first got this--not even by a doctor who was a friend and who I saw

weekly. Now I think to myself, if he had tested me in the acute

lyme/babs infection it probably WOULD have been positive, and then I

probably WOULD have researched and ended up talking to Krause, but

five years ago, and done 7-10 days of mepron/zith, and zith treats

lyme also...oh well, spilt milk. I couldn't get the ID doc to test

for it either. I had an obvious case of acute lyme, babesia

coinfection was an obvious consideration since I couldnt seem to get

over it, and I couldn't get a test.

I remember you talking about the hypothermic shock--yikes.

You were brave and smart and strong. I have decided to do a serious

cleansing program (colonics, liver flush) over the next month or two

and then I'll probably try the drug. I really don't want to build

resistance. You hit it and hit it hard, and this drug looks good to

me.

[Guest guest]

Tony:

Got your crystal ball out?

This is someting I've discussed with Nellie previously.

It's possible something was transferred thru the maternal line

to me in utero.

My mother contracted pertussis 3 years before I was born, and never

really recovered. a few years after I was born she was Dx'd with

Sarcoidosis. She was on corticoid steroids for years and died at 52

in 1976 of a lung hemorage.

All my problems presented in 1976 after emergency surgery ( my

suspecion is I received another load of pathogens from the blood

tranfusion) - I was operated on again in 1980 and the surgeon sent

internal tissues to the path lab - and I read that report in 1999.

Every tissue was considered chronically inflammed, but no tissue was

examined for pathogens.

So yes. I know I was chronically inflammed at least since the late

70's .

But before that - I was perfectly healthy, with a normal blood profile

although I have to add that I was also operated on as a child in

1956 as I was born with a ectopic kidney & they re-positioned it.

The 1976 operation was complete bowel obstruction caused from

adhesions from the 1956 operation.

So I really have had LOTS and lots of EXTRA opportunities for

pathogens to enter my body -

B.

> > > > More things I read:

> > > >

> > > > immunopathophysiology of B bovis and P falciparum infections

> > > > ig wright bv goodger ia clark

> > > >

> > > > immune evasion by B bovis and P falciparum: cliff dwellers of

> the

> > > > parasite world

> > > > dr allred

[Guest guest]

I had a full torso ring CTSCAN in 2000, and they think I may have

" auxillary " spleen at the end of my pancreas- as the pancreas isn't

shaped correctly (kind of a long tail on it) - or splenic tissue

somewhere - or I would have died as a child. They think my

anatomical presumed spleenlessness runs thru the family line

somewhere.

Nuclear sintography is the only way to tell for sure (tagged for

splenic tissue) but I've said no to that test.

Barb

> Barb, I recall that you said you may have some splenic tissue

> somewhere in the body?

>

> Riamet is not arthemos plus abx, its arthemos plus an antimalarial

> that is in the larium family. Thats why I'm a little worried,

unlike

> doxycycline, larium and its kin are known to have lots of side

> effects even in those who are not drug sensitive (like moi). I took

> 1/4 capsule of artemisnin from ARG last night--got headache and

achy

> liver. OTOH, the reasoning for it is really good, as arthemos and

> all artemisinin derivatives have a short half life (3-4 hours), and

> this has a long half life (3-4 days). In fact, I was wondering if

> anybody JUST taking artemisinin twice a day is only getting peak

> blood levels for an hour or two, and allowing the parasites to grow

> back in between.

>

> I think you're right--Krause said you can have half a percent

> infestation in the blood...and a doctor friend of mine who has lyme

> nad babs says even 1-2% infection will make you feel like crap and

> feel very sick.

>

> However apparently the bone marrow CAN be much higher infection

rate.

>

> Barb, I agree autoimmune diagnosis is the kiss of death, but even

> without such a diagnosis I couldn't get tested for babesia when I

> first got this--not even by a doctor who was a friend and who I saw

> weekly. Now I think to myself, if he had tested me in the acute

> lyme/babs infection it probably WOULD have been positive, and then

I

> probably WOULD have researched and ended up talking to Krause, but

> five years ago, and done 7-10 days of mepron/zith, and zith treats

> lyme also...oh well, spilt milk. I couldn't get the ID doc to test

> for it either. I had an obvious case of acute lyme, babesia

> coinfection was an obvious consideration since I couldnt seem to

get

> over it, and I couldn't get a test.

>

> I remember you talking about the hypothermic shock--yikes.

>

> You were brave and smart and strong. I have decided to do a serious

> cleansing program (colonics, liver flush) over the next month or

two

> and then I'll probably try the drug. I really don't want to build

> resistance. You hit it and hit it hard, and this drug looks good to

> me.

[Guest guest]

Barb that is correct!!!

> > > > > More things I read:

> > > > >

> > > > > immunopathophysiology of B bovis and P falciparum

infections

> > > > > ig wright bv goodger ia clark

> > > > >

> > > > > immune evasion by B bovis and P falciparum: cliff dwellers

of

> > the

> > > > > parasite world

> > > > > dr allred