More info on MB-12, mouth sores, etc.

[Guest guest]

Another missile from my buddy Jim Neubrander:

Dear Jaquelyn:

What I write below is once again long but hopefully will help explain some of

the questions and concerns your parents shared with you.

The following I speak from my pathology training, not my interest in DAN!

Methyl-B12, when injected deep enough into the fat and no where close to muscle

cannot " leach out " fast enough into the bloodstream in a high enough

concentration to cause tissue necrosis or tissue breakdown. Technique is

usually the culprit as discussed in my latest update to the injection technique

shown on my website at www.drneubrander.com. " Sores " imply tissue breakdown and

necrosis or sloughing of tissue, even if only to a mild degree. However, all

pathologists know that a true necrotic and sloughing lesion takes about 3 weeks

to heal and not 2-3 days. Therefore, " whatever " was being seen needs to be

better described so that I can reevaluate " the mechanism of action " that may be

taking place [what a pathologist does].

I have learned most of my medicine from parents as I try to make clear everytime

I speak. Therefore I do not take lightly " anything " I hear. What I do attempt

to do is put it in perspective with known science, known physiology, known

pathophysiological mechanisms, and with those things we are all learning prior

to publication. Therefore, when considering this mother's " sores " and the other

mother's similar report in an email dated later than this one, I must begin the

process of asking myself what was going on here. I do believe something was

happening but can only speculate.

Most parents do not give the shots shallow enough to guarantee a true

subcutaneous shot. Therefore, a sudden high dose burst of methylating agents

into the blood stream (MB12, folinic acid) and other confounding " things " in the

other supplements could theoretically activate viruses, stir up localized detox

reactions, kick up " allergies " or sensitivities, etc. Therefore, once again

this points out how important it is to change only methyl-B12 when evaluating

its actions and not to be adding multiple other things. It also points out that

unless technique is perfect, many unexpected things may follow.

In answer to the question about hyperactivity and whether to continue the shots

let me give the following explanation. After 50,000+ shots and observing each

of them personally I will say that I will be making it very clear in my lectures

that several factors must be equally in place concurrently in order to judge

" methyl-B12 " and not be judging the multiple confounding factors. The critical

factors are density of concentration of the base methyl-B12 solution [less dense

solutions leach out more quickly and are less able to be controlled], the

delivery into fat and nowhere near muscle [the reason explained in detail in my

injection instructions on my website], the use of buttock fat only [different

types of fat are known to accumulate, retain, and release substances at

different rates], the total dose delivered and the frequency. I have data

documenting that each of these factors is important and that if any one is out

of place, " response " will still occur but " intensity of response " will be far

less. In addition, the protocols I use in my office systematically add

additional factors after the 5-week clinical trial of MB12. The first one is

folinic acid. Each is added in a certain order and with enough time allowed to

evaluate the results of the first before adding the second.

In my opinion it is a mistake and a misunderstanding of the biochemistry to use

TMG with methyl-B12 if methyl-B12 shows benefits, with or without side effects

[when methyl-B12 has already been in place without anything else affecting the

ability to evaluate its actions.] Dr. 's study is being misapplied, in my

opinion, by parents and clinicians believing that " the protocol " proved

that folinic acid, TMG, and methyl-B12 were necessary to be together to get the

results. This is not the case at all. The misunderstanding comes from " the

evolution " of the experiment and the fact that TMG was already being used in the

study BEFORE the MB-12 was added. One problem with the simultaneous addition of

TMG with MB12 is that " more " methyl donors does not " success make " .

Homocysteine can only receive one methyl group at a time. Therefore it can

receive a methyl group from MB12 or a methyl group from TMG but not from both at

the same time. Therefore, if both TMG and MB12 are around at the same time,

something is going to have to back up and cause the child's body to try to find

a way to get rid of this " good thing now acting toxic " [toxic here is used in a

very loose analogous form and not in a strict sense of the word]. It is

important to remember that TMG acts only in the liver and kidney while MB12 acts

everywhere in the body. What biochemists should expect is that if the initial

Jill study used folinic acid with MB12, the same results would have

occurred in the first phase of the experiment without needing to go to the

second phase.

Once more let me say that I judge methyl-B12 for what methyl-B12 does and I make

very sure that the side effects can be documented as intolerable vs. nuisance

[even if they are " big " nuisances] before I lower to dose or stop the shots. I

define nuisance hyperactivity as being able to learn and stay on task in a

controlled environment like school no matter how much increased " activity " there

is at home. Home is a child's safe haven. Home is where the parents spend 90%

of their time loving the child and making it " his/her place " , letting the child

know that this is his/her home and where love abounds. Only 10% of the time at

home is spent disciplining and educating the child. School, the controlled

environment, is just the opposite where 90% of the time is spent educating and

disciplining and only 10% of the time is spent teaching the child s/he is loved

and accepted. Therefore, if the child can actually learn, stay on task, etc.,

in school and if the child is showing the improvements that are specific to

methyl-B12, not to autism per se [as documented by hundreds of parents for the

last 2 1/2 years in thousands of Parent Designed Report Forms and thousands of

Parent Specifics Documentation Letters] both at school and at home, then I

recommend that the shots be continued at the same dose [if based on the multiple

factors stated in the protocol I use in my practice].

I have so much to share -- little hints here and there that seem to help the

methyl-B12 phenomenon work better than when I just was new to the whole thing.

Hopefully the message will continue to get out there and parents will be able to

understand how to judge " this methyl-B12 thing " and stick with it long enough so

that after 1.5 to 2 years they will have a child who may not be well, but who

has definitely climbed a position or two up the ladder of the classroom of life.

As always, your friend, colleague, and admirer,

Jim Neubrander, M.D.

--------------------------------------------------------------------------------

From: Jaquelyn McCandless

Sent: Monday, January 31, 2005 3:46 PM

To: Dr. Neubrander

Subject: Lip sores on MB-12?

Jim: This is the 2nd mom who is reporting this. Any ideas as to why? Jaquelyn

My daughter has been on mb12 for a month along with

> > folinic and a bunch of the normal supps. Approximately

> > 24 hours after administration of the shot, she gets a lip

> > sore that fades 2-3 days later just in time for her next

> > shot. What does this mean? Should I stop?

> > She's very hyper so we might stop for a month anyway.