Tissue Distribution - Tony

[Guest guest]

Indeed, if arsenical therapy has that kind of great tissue

penetration, that would impress me too and indicate a likely basis

for its success in Tarello's case (and all those cats and dogs he

treated).

Do we know anything about the MBCs of these arsenic compounds, vs.

the level of concentration where they become toxic to people? Does

the MBC change, depending on the bugs in question? It seems like a

post ago or so you were saying they can adapt, so presumably its

variable.

Not sure where you're going with the 80grams of penicillin vs. 2

grams of ceftriaxone thing - the jab in the ass does not go into the

vein, what you'd need to compare is the amount entering the

bloodstream over a given interval, right?

I know when I was on Bicillin the measure was international units,

something like 1.2million per twice-weekly shot. No idea how that

translates into grams, but it seems almost moot - intravenous and

intramuscular delivery systems are apples and oranges. You don't

shoot Bicillin into veins, you keep an epipen around in case you do

that by accident because the result can be anaphylaxic shock.

Anyhow, thanks for replying - it sounds like you're saying the

reason we've got Tarello and the Newcaste guys saying 'antibiotics

are useless' is that they were using poorly designed oral regimens,

and that instead what a lot of CFS patients need, once they've had

their cultures done, is IM or IV antibiotic treatment, with

combinations of drugs to minimize resistance.

Am I getting you right?

> > > > Hey Tony, I found that study you posted about the

therapeutic

> > use

> > > of

> > > > PST [purified staph toxin] totally fascinating.

> > > >

> > > > I was wondering if you could elaborate on a few things:

> > > >

> > > > 1) I easily found multiple references to the PST

experiments,

> > but

> > > > not to the initial findings that gave rise to them, which I

> > think

> > > is

> > > > where a lot of your excitement came from. Can you help point

> me

> > to

> > > > more documentation on just what the Newcastle researchers

> found

> > > that

> > > > was different in CFS patients? What was that test they used,

> > that

> > > > was telling us docs weren't sure how to interpret?

I'd

> > > like

> > > > to know as much about that as possible.

> > > >

> > > > 2) Readings gave me the impression that PST was widely used

in

> > > > Russia, and that this had something to do with a prevalence

of

> > abx-

> > > > resistant staph - are you familiar with that side of it? I

> found

> > > > references to it being used for atopic dermatitis, as well

as

> > CFS

> > > > and FM - anything else?

> > > >

> > > > 3) It seems kinda unfortuante that the PST CFS/FM studies

> relied

> > > so

> > > > heavily on a psychiatric assessment, the Comprehensive

> > > > Psychopathological Rating Scale, to determine improvements.

> Any

> > > idea

> > > > why things more directly relevant to the diagnoses, like

> tender

> > > > point sensitivity, exercise tolerance, physical stamina,

> > cognitive

> > > > performance, etc weren't used?

> > > >

> > > > 4) I found references to one of the Newcastle guys

> > > > saying " antibiotics are useless in these patients. " What do

> you

> > > make

> > > > of that statement? It seems like that assessment led

directly

> to

> > > the

> > > > use of PST, but I'd like to know more on how they arrived at

> it.

> > > >

> > > > 5) Do you know if PST is still in wide clinical use in

Russia?

> > Has

> > > > it ever made into clinical use anywhere else?

> > > >

> > > > I know, lots of questions. But that's what happens when I

read

> > > > something interesting. I wanna know more.

> > > >

> > > > The highest-priority question is my first one, about the

> testing

> > > > that lead up to this. Where the heck is the documentation

for

> > > that?

> > > > Did I just miss it?

> > > >

> > > > Thanks much,

> > > >

> > > > S.