TACI Is Mutant In Common Variable Immunodeficiency And IgA Deficiency

[Guest guest]

I wonder how many of you have had a serum IgA test, and how many of you

have a deficiency and what relationship this has to your chronic

infections. It's a cheap test, about $35 the last time I checked.

I think that the new finding (two studies in Nature Genetics, August

2005) of a defective gene in IgA Deficiency is exciting news for people

with Selective IgA Deficiency, a disease in the same group as AIDS and

the " bubble boy " syndrome.

As far as I know, IgA Deficiency has not been linked to Lyme Disease,

but I don't think anyone has ever looked for a link. It has been

linked to infections of the mucous membranes lining the mouth, airways

and digestive tract.

The gene, encoding the protein TACI, is involved in switching between

antibody types in antibody-producing white blood cells.

http://hum-molgen.org/NewsGen/07-2005/msg13.html

http://www.medicalnewstoday.com/medicalnews.php?newsid=27259

http://www.medindia.net/News/View_news_main.asp?t=gn & x=3947

Sue ,

Upstate New York