Matt, Tony, SCVs

[Guest guest]

Matt, alas I am heading back to my chemistry homework dungeon, but I

did vaguely get the sense not all the SCV phenotypes were vit-K-

dependant.

I did review your posts on the subject, where you brought up vit K,

and looked at what papers you had ref'd. I dont know whether K enters

cells well.

One thing I am sure of: one of Proctors papers says that pseudomonads

and some other genera too are capable of SCV variation. That strikes

me as important.

Tony, ever visualized these guys? I think they take several days to

appear on agar at 37 degrees, are pale, and obviously have small

colony size. The thing is, I have read that they can easily be

overgrown by normal cells if there are any normal cells present.

Unfortunately, those new anti-staph-SCV drugs I posted about turned

out to all be inferior to an existing B-lactam in the animal models

used. But it appears SCVs may be intracellular in human

staphylococcal osteomyelitis and cystic fibrosis, so there was a real

question of whether these models faithfully re-created those

situations... also most mammals may be genetically insuceptible to

chronic staph osteomyelitis so it may be hard to properly model the

real thing.

>

> >

> > - is there anything to do about it all