h. pylori remedy (Sequential therapy)

[Guest guest]

Short course sequential therapy looks very promising.. right up my

alley. This news first came out in 2003.

Barb

Aliment Pharmacol Ther. 2005 Jun 15;21(12):1419-24

High rate of Helicobacter pylori eradication with sequential therapy in

elderly patients with peptic ulcer: a prospective controlled study.

Zullo A, Gatta L, De Francesco V, Hassan C, Ricci C, Bernabucci V,

Cavina M, Ierardi E, Morini S, Vaira D.

Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita

Hospital, Rome, Italy. zullo66@...

BACKGROUND: Helicobacter pylori eradication rates with triple therapies

are decreasing, and few data in elderly patients are available. A 10-

day sequential regimen succeeded in curing such H. pylori infection in

unselected patients. AIM: To compare this sequential regimen and the

standard triple therapy for H. pylori eradication in geriatric patients

with peptic ulcer. METHODS: Overall, 179 H. pylori-infected patients

with peptic ulcer were enrolled (mean age: 69.5 years; range: 65-83).

Patients were randomized to 10-day sequential therapy (rabeprazole 20

mg b.d. plus amoxicillin 1 g b.d. for the first 5 days, followed by

rabeprazole 20 mg, clarithromycin 500 mg and tinidazole 500 mg, all

b.d., for the remaining 5 days) or standard 7-day triple regimen

(rabeprazole 20 mg, clarithromycin 500 mg and amoxicillin 1 g, all

b.d.). Helicobacter pylori status was assessed by histology and rapid

urease test at baseline and 4-6 weeks after completion of treatment.

RESULTS: The sequential regimen achieved eradication rates

significantly higher in comparison with the standard regimen at both

intention-to-treat (94% vs. 80%; P = 0.008) and per-protocol (97% vs.

83%; P = 0.006) analyses. In both treatment groups, compliance to the

therapy was high (> 95%), and the rate of mild side-effects was

similarly low (< 12%). At repeated upper endoscopy, peptic ulcer

lesions were healed in 97% patients, without a statistically

significant difference between the sequential regimen and the standard

triple therapy.

CONCLUSIONS: In elderly patients with peptic ulcer disease, the 10-day

sequential treatment regimen achieved significantly higher eradication

rates in comparison with standard triple therapy.

PMID: 15948808 [PubMed - in process]

> Does anyone have a remedy for the bacteria h. pylori that has been

> known to cause ulcers? I am thinking something along the lines of

> graprefruit seed extract or olive leaf extract, but if there is an

> antibiotic, which is it?

>

> My alternative practitioner has identified an unknown infection in my

> upper GI that so far has not responded to doxy or flagyl even tho our

> testing method showed it would, so I am confused and need an

> alternative, if possible, to antibiotic treatment.

> This mystery infection hurts and has been around a long time,

possibly

> a few years and only now starting to cause constant discomfort.

> Any advice, anyone? I am thinking that whatever kills h. pylori would

> probably have an effect on this one, too, but it's just a guess.

> *S*