HCQ/tini

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Jim:

I did a search for you.

You may want to pass this info on to your Dr.

I agree with HCQ taken with a fungal, as the alkalizing properties of

HCQ on the cell compartment work the same for the 'azoles' as they do

for abx. You could kill alot with the CORRECT dosages.. key words

being the CORRECT. DO not assume the normal mono therapy doses apply

with these two in combo.

Tinidazole's main pathway for metabolism and is considered a

cyp3A4 substrate (and a minor 2C9 substrate).(see ref 1)

CQ (chloroquine)uses cyp3A4 as one of the pathways for it's metabolism

(reference 2) so most likekly HCQ does too.

There's going to be competition for this enzyme, resluting in one or

the other (drug) to reach higher consentrations in the body... and

since the consentration of HCQ varies enormously between individuals -

I would be very carefull.

I would not assume adverse reactions with this combo to be

a 'herx'. It's much more likely a drug-drug interaction.

Ref 1

http://www.tindamax.com/Med%20Letter.pdf

ref 2

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=pubmed & dopt=Abstract & list_uids=12967198 & query_hl=29

Barb

PS.

I think mixing HCQ with some drugs as 'smart bombs'.. but mixed the

wrong way and you get a 'dirty bomb' with alot of collateral damage.

> > As for drugs vs clearing, I have some

> > hydrochloroquinine to try and see if it makes a

> > difference in my reactions to the Tini.

>

> Somewhere I read that these shouldn't be taken

> together but I can't

> find the reference now. Did Stratton say it was okay?

>

> - Kate D.