HCQ/ tini interactions was Porphyria, Stratton, etc

[Guest guest]

Most drugs that use the P450 system for metabolism are thought to use

one pathway. But there are some drugs (called substrates) that use

multiple path ways. There are also drugs called 'inhibitors' , that

hinibit one path way, which in turn can raise the consentration

levels of another drug that wants to use that same pathway for it's

metabolism. An 'inducer' will cause faster clearance of a drug that

uses the same pathway(s).

HCQ is classified as an inhibitor of cyp2d6 inhibitor, and a

substrate for cyp3A4 and 2D8. (And since these have only classifed

recently, I bet there's more).

There isn't much in the lit about Tini - but it's a close relative to

metronidazole- which shouldn't interact with HCQ- but you can't be

certain, becuase it's NOT exactly the same.

It might be like DOxy and HCQ - for which there's not problems- but

with HCQ and Mino there sure is a reaction (and I'm pretty sure HCQ

causes higher consentrations of Mino in the body, because I had to

decreas the HCQ or I had Mino toxicity effects (and I can normally

take 200mg Mino a day till the cows come home - and I can noramlly

take very high doses of HCQ as a mono therapy without side effects.).

So- just becarefull and be aware that HCQ can interact with alot of

drugs becuase it uses (or inhibits) multiple P450 pathways.

Barb

> > As for drugs vs clearing, I have some

> > hydrochloroquinine to try and see if it makes a

> > difference in my reactions to the Tini.

>

> Somewhere I read that these shouldn't be taken together but I can't

> find the reference now. Did Stratton say it was okay?

>

> - Kate D.