Quick 25D, 1,25D question (but nerdy)

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As I start to take a gander at this literature, one (quick) question comes to

mind: If

1,25D is over-regulated by macrophages (e.g., not the usual 25D-> 1,25D kidney

stuff), that WOULDN'T per se require a concommitant drop in 25D (the " using it

up "

hypothesis). Thus, 1,25D dysregulation from inflammation would exist

independent

of any 25D deficiency. In contrast, LOW 25D and HIGH 1,25D would implicate a

deficiency vs a immune dysregulation, no?