Re: OspA stuff

[Guest guest]

Yes, he suggested OspA might induce autoreaction against the human

molecule LFA-1. (Which is a bit different than suggesting it is a

super-powerful antigen in itself.) He has since withdrawn this idea.

I dont think he has withdrawn his claim that he sees OspA

seropositivity in almost all of the people he deems to have

borreliosis. But the paper posted by Scha yesterday may explain

why that is.

<jenbooks13@h...> wrote:

> Hi Robyn. Well, Steere himself pointed out ahead of making the OspA

> vaccine, that it could cause autoimmune reactions. Which is what

> hapepned--and why they pulled the vaccine, because it made some

> people so sick. I'll do a little bit of literature searching for

you

> too sometime in the next week and try to find citations.

> > Jill said:

> >

> > " Its a very nasty critter that changes all its surface antigens

> > constantly AND binds complement. ANd its OspA is highly

> immunogenic,

> > causing some of us to have an outsize reaction. "

> >

> > You've got me as excited as I get these days Jill.

> >

> > I need to understand your statement as I believe it applies to my

> > situation. My Igenix Bb #30 IgG is +++ and IgM is +. I've had

> horrific

> > reactions to all antibiotics/antifungals. Would you kindly

explain

> or

> > direct me to somewhere that explains how/why 'OspA is highly

> > immunogenic causing outsize reaction'?

> >

> > Thank you,

> >

> > Robyn

[Guest guest]

Robyn, work youy might want to look at is University of Utah, Janet

Weis.

Or can look into it for you .

She has basically found in mice studies that your genetics determine

your inflammatory response to the spirochete and its lipoproteins.

Your symptoms, and where you get sick, depend on your genetics (i.e.

carditis, arthritis, etc.)