exogenous antibody as antibacterial

[Guest guest]

Awesome!

Check out this:

http://www.nature.com/nrmicro/journal/v3/n5/abs/nrmicro1149_fs.html;jses

sionid=5D2A19CF469D434C4389C6BD0EC3506E

Also, PMID 14519077 says you can get the Fab end alone (the " head " end

with the hypervariable region that binds the antigen) and that this

fragment has better tissue penetration. This is significant because it

is known that there are antibodies which are autonomously borrelicidal.

Perhaps the Fab end alone would be equally active. Same principle could

apply to say an Ab targeting the Bb fH-binding proteins (if one could

be developed that would not block the fH binding sites on human cells).

Of course this wont be useful for getting at anything that might be in

a host cell.

> also, go search pub med and then you can get free article online,

> " P Burnie and Ruth C s, The Renaissance of antibody

> therapy, Journal of Antimicrobial Chemotherapy) 1998 "

>

> It's obviously the precursor to their later work with fungi and

staph.

> Its a nice review.

>

> I like them! I like techniques that are in sync with the body and

> not broad spectrum with side effects.