why ceftriaxone (vs other B-lactams)?

[Guest guest]

If anyone can add something, be it data or further aspects of

consideration, heres the analysis of B-lactam therapy I'm starting on.

FACTORS:

- brain penetration... v important

- host cell penetration... may be critical

- organism penetration/lethality

[above 3 factors probably depend largely on

hydrophobicitiy/hydrophilicity of various drugs at physiologic pH,

but theres probably good empirical data to use, so here theoretics

are just to organize ones knowledge]

- expense... are the older drugs much cheaper? if so perhaps one

could obtain a longer-term IV treatment using them. Longer is better.

- half-life in serum and brain... longer the better

- recalcitrance of drug to organisms' B-lactamases (not important for

Bb as far as I know)

- toxicity... bah who cares (just kidding). Maximum safe/affordable

dose may be important as L-forms may become sensitive (if at all)

only at a higher concentration.

- where data are available, a good consideration is

activity/inactivity within host cells due to causes mysterious (there

are examples where such inactivity doesnt correspond to any sensible

explanation)