efflux as model for drug-refraction of CFS/lyme etc

[Guest guest]

" Most drug efflux pumps confer a multi-drug resistance phenotype,

corresponding to the large variety of substrates they may recognize

[...] [single-]antibiotic-[class-]specific efflux pumps appear to be

restricted to those organisms producing antibiotics[...] "

http://tinyurl.com/8ae6m

As I posted, it appears from the genome that Bb has high efflux

capacity. If Bb is a chronic pathogen, this might underlie its

intrinsic multidrug resistance. Why might one bacterium naturally have

a much higher efflux phenotype than another? Why might Bb naturally

have a much much higher efflux phenotype in vivo than in glass -

particularly in humans moreso than other mammals, and most of all in

humans long-infected?

Periplasmic organisms like classical Bb would seem like theyd be the

best detoxers, but it seems the Wirostko- bacterium is also

intrinsically multi-drug resistant and most of its biomass is single-

membrane-bound. Of course the same might be true of Bb in the human as

well.