new paper on Staph aureus small colony variants

[Guest guest]

This new paper finds that an S aureus exosubstance (taken from

culture supernatants) is able to reverse one drug-resistant S aureus

SCV phenotype:

http://iai.asm.org/cgi/content/full/73/7/4119?view=long & pmid=15972501

As we have discussed, " The persistence of S. aureus in CF and other

persistent infections such as osteomyelitis and device-related

infections has been associated with the isolation of S. aureus small-

colony variants (SCVs). "

These phenomena could have relevance not only to staph, but could

potentially shed light on the mechanisms of abx refraction displayed

by Bb in vivo. I will be starting undergrad research in September,

and it seems odds are high that I'll have to work on someone elses

project, but there is a chance I could do something of my own if I

get my head together ASAP. I wonder if it may be possible to produce

pan-abx-resistant SCV-like phenotypes of some safe, beginner's lab

organism that I would be allowed to work with, and try to explore

how the pan-abx refraction works. So if anyone gets some insight on

this stuff, gimme a ring. I am hitting the lit trying to find out

about things like, say, just what percentage of an E coli cells

ribosomes are incapacitated when it is exposed to a growth-

abolishing concentration of doxy.

[Guest guest]

ERic, how old are you anyway----you're about to go to college? I

recall you're doing much better these days after abx etc.

Why don't you go apprenctice yourself to Lynn Margulis? She's a

genius and works on spirochets (not bb in particular tho). She's at

Amherst.

> This new paper finds that an S aureus exosubstance (taken from

> culture supernatants) is able to reverse one drug-resistant S

aureus

> SCV phenotype:

>

> http://iai.asm.org/cgi/content/full/73/7/4119?

view=long & pmid=15972501

>

> As we have discussed, " The persistence of S. aureus in CF and other

> persistent infections such as osteomyelitis and device-related

> infections has been associated with the isolation of S. aureus

small-

> colony variants (SCVs). "

>

> These phenomena could have relevance not only to staph, but could

> potentially shed light on the mechanisms of abx refraction

displayed

> by Bb in vivo. I will be starting undergrad research in September,

> and it seems odds are high that I'll have to work on someone elses

> project, but there is a chance I could do something of my own if I

> get my head together ASAP. I wonder if it may be possible to

produce

> pan-abx-resistant SCV-like phenotypes of some safe, beginner's lab

> organism that I would be allowed to work with, and try to explore

> how the pan-abx refraction works. So if anyone gets some insight on

> this stuff, gimme a ring. I am hitting the lit trying to find out

> about things like, say, just what percentage of an E coli cells

> ribosomes are incapacitated when it is exposed to a growth-

> abolishing concentration of doxy.