Re: Follow-up for Rich on Glutathione

[Guest guest]

Hi Rich,

Two quick GSH-related questions:

1. Can you recommend a listserv or two where parents of children with

autism discuss the therapies they are trying. (I have a grandchild

with autistic-like problems.)

2. Can you tell us what you know about the effectiveness of transdermal

GSH, and recommend a compounding pharmacy that makes it. Have you

corresponded with anyone who has tried different routes such as IV,

nasal, transdermal and suppository, and can put the different methods

into perspective?

Here is one transdermal discussion I found:

http://www.leesilsby.com/autism.html

Stabilized Reduced Glutathione Transdermal Gel™

Lee Silsby’s Stabilized Reduced Glutathione Transdermal Gel™ has been

proven to maintain its stability.

The stability of a product refers to the ability of an active

ingredient to retain its full potency when incorporated into a dosage

form such as a capsule, liquid, cream, or gel. Many active ingredients

decompose – either gradually or rapidly – when added to an improperly

formulated dosage form.

Several years of research and development have led to the creation of a

formulation that we feel is the very best system for delivering reduced

glutathione into the body. This was a particularly difficult task

because of the poor stability of glutathione when added to a liquid,

cream, or gel.

In order to insure that our glutathione formulation does, in fact,

remain stable, we had it tested for stability by an independent

laboratory. At the same time, another glutathione formulation commonly

used by other compounding pharmacies was also tested for stability. The

results of the testing showed that the glutathione in our transdermal

gel formulation remained virtually 100% stable, while the glutathione

in the standard formulation underwent rapid decomposition. In fact, as

illustrated by the table below, the standard formulation lost 85% of

its stability within three months.

Priding ourselves in our constant innovation in formulation

development, we have recently made additional adjustments to our

glutathione gel. These adjustments reflect our most current

understanding about how best to achieve the highest skin absorption of

topically applied medications. Our knowledge in this area has been

developed through working with doctors and their patients on a clinical

basis, as well as hundreds of hours of research into and development of

transdermal dosage forms.

How stable is your glutathione?

Glutathione Graph

====

Sue ,

Upstate New York

[Guest guest]

Hi, Sue.

One group of that type that I know of is the one called Autism-

Mercury in . I can't vouch for the quality of the

information shared there, since I haven't followed it myself. I

think quite a few of the people there discuss Andy Cutler's

protocol. I do think that the information on the website

http://www.generationrescue is good.

I don't know of any data evaluating the effectiveness of transdermal

glutathione. Beside the LeeSilsby pharmacy that you mentioned, I

know that Kirkman Labs also sells a transdermal glutathione product.

I don't have comparative data for the different ways of attempting

to put glutathione into the blood, and I sure wish I did! There's

no question that IV and IM do get it into the blood.

Based on experience with rectal suppositories in general, I would

expect that glutathione suppositories would work fairly well, and I

have heard from one person that they are effective for him. The

price is also much lower than for IV infusions, and one can do the

suppositories oneself.

The nebulized or aerosol approach certainly gets it into the lungs.

I expect that it does raise the blood level, either directly or by

decreasing the demands for systemic glutathione by the lungs.

I doubt if nasal sprays put much into the blood, based on an

anecdotal report from a doctor who uses them.

I suspect that sublingual troches do put glutathione into the blood,

but one person who tried them told me that they didn't feel

anything. A doctor who uses them told me that if his patients use

them too much, they feel dizzy, so I think something must be going

in from them.

I don't know how well the transdermal products work. It's difficult

to keep glutathione from oxidizing, particularly if it's in aqueous

solution in contact with the atmosphere at room temperature for very

long.

Lipoceutical Glutathione and the competing liposomal glutathione

offered on the web probably get the glutathione in fairly well. I

have had good reports from a doctor about this, and some people on

the glutathione--cystic fibrosis list report good results. This is

not a cheap way to do it, either, but I think it is pretty

effective, and not difficult to use. It's taken orally. It offers

the potential of carrying glutathione right through cell membranes

and into the cells.

At my current state of ignorance, I think the IV and IM are the

surest ways to get glutathione directly into the blood, but not very

convenient and somewhat costly. If I were doing it, and didn't have

much money, I think I would try the suppositories supplied by

Wellness Pharmacy, and if I did have the money, I would go for

Lipoceutical Glutathione. I'm always open to new information from

people who have tried these various approaches.

Rich

> Hi Rich,

>

> Two quick GSH-related questions:

>

> 1. Can you recommend a listserv or two where parents of children

with

> autism discuss the therapies they are trying. (I have a

grandchild

> with autistic-like problems.)

>

> 2. Can you tell us what you know about the effectiveness of

transdermal

> GSH, and recommend a compounding pharmacy that makes it. Have you

> corresponded with anyone who has tried different routes such as

IV,

> nasal, transdermal and suppository, and can put the different

methods

> into perspective?

>

> Here is one transdermal discussion I found:

>

> http://www.leesilsby.com/autism.html

>

> Stabilized Reduced Glutathione Transdermal Gel™

> Lee Silsby's Stabilized Reduced Glutathione Transdermal Gel™ has

been

> proven to maintain its stability.

>

> The stability of a product refers to the ability of an active

> ingredient to retain its full potency when incorporated into a

dosage

> form such as a capsule, liquid, cream, or gel. Many active

ingredients

> decompose – either gradually or rapidly – when added to an

improperly

> formulated dosage form.

>

> Several years of research and development have led to the creation

of a

> formulation that we feel is the very best system for delivering

reduced

> glutathione into the body. This was a particularly difficult task

> because of the poor stability of glutathione when added to a

liquid,

> cream, or gel.

>

> In order to insure that our glutathione formulation does, in fact,

> remain stable, we had it tested for stability by an independent

> laboratory. At the same time, another glutathione formulation

commonly

> used by other compounding pharmacies was also tested for

stability. The

> results of the testing showed that the glutathione in our

transdermal

> gel formulation remained virtually 100% stable, while the

glutathione

> in the standard formulation underwent rapid decomposition. In

fact, as

> illustrated by the table below, the standard formulation lost 85%

of

> its stability within three months.

>

> Priding ourselves in our constant innovation in formulation

> development, we have recently made additional adjustments to our

> glutathione gel. These adjustments reflect our most current

> understanding about how best to achieve the highest skin

absorption of

> topically applied medications. Our knowledge in this area has been

> developed through working with doctors and their patients on a

clinical

> basis, as well as hundreds of hours of research into and

development of

> transdermal dosage forms.

>

> How stable is your glutathione?

> Glutathione Graph

> ====

>

> Sue ,

> Upstate New York