Re: Rhodiola Rosea Conserves Glutathione in Erythrocytes

[Guest guest]

Hi, .

I had heard of Rhodiola before, but I didn't know about its effect

on preserving glutathione. I appreciate your posting this abstract.

Rich

> I ordered this for myself a few days ago, without knowing it had

any

> connection to Glutathione. It's been in use in traditional

medicine

> for a long time and I was looking for energy tonics that I thought

> would be safe for someone like me.

>

> Rich, have you read about this one?

>

> Biofactors. 2004;20(3):147-59.

>

> In vitro protective effect of Rhodiola rosea extract against

> hypochlorous acid-induced oxidative damage in human erythrocytes.

>

> De Sanctis R, De Bellis R, Scesa C, Mancini U, Cucchiarini L,

Dacha

> M.

>

> Istituto di Chimica Biologica " Giorgio Fornaini " , Universita degli

> Studi di Urbino " Carlo Bo " , Urbino (PU), Italy.

>

> Rhodiola rosea L. (Crassulaceae) is a plant living at high

altitudes

> in Europe and Asia. Its roots have long been used in the

traditional

> medical system of these geographical areas to increase the

organism

> resistance to physical stress; today, it has become an important

> component of many dietary supplements.

>

> In this study we investigate the antioxidant capacity of the R.

> rosea aqueous extract evaluating its ability to counteract some of

> the main damages induced by hypochlorous acid (HOCl), a powerful

> oxidant generated by activated phagocytes, to human erythrocytes.

>

> Ascorbic acid was used as a reference substance because of its

> physiological HOCl-scavenging ability. Our study demonstrates that

> R. rosea is able to significantly protect, in a dose-dependent

> manner, human RBC from glutathione (GSH) depletion, glyceraldehyde-

3-

> phosphate dehydrogenase (GAPDH) inactivation and hemolysis induced

> by the oxidant.

>

> Furthermore, we demonstrate that R. rosea aqueous extract acts

from

> the inside of the erythrocyte suggesting a probable involving of

> cell components. The protection on GSH afforded by the R. rosea

> extract with respect to ascorbic acid, occurred also if added 2 or

5

> min. later than the oxidant, suggesting a more rapid or powerful

> effect.

>

> PMID: 15665385 [PubMed - indexed for MEDLINE]