More Newcastle CFS Pub Med docs: blood parameters of oxidative stress

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I'm not sure if Tony mentioned this one, but it seems to lend itself

to the oxidative stress emphasis of Rich's work, and it's the same

set of researchers.

Redox Rep. 2000;5(1):35-41.

Blood parameters indicative of oxidative stress are associated with

symptom expression in chronic fatigue syndrome.

s RS, TK, McGregor NR, RH, Butt HL.

Department of Biological Sciences, University of Newcastle,

Australia.

Full blood counts, ESR, CRP, haematinics and markers for oxidative

stress were measured for 33 patients diagnosed with chronic fatigue

syndrome (CFS) and 27 age and sex matched controls. All participants

also completed symptom questionnaires.

CFS patients had increases in malondialdehyde (P <0.006),

methaemoglobin (P <0.02), mean erythrocyte volume (P <0.02) and 2,3-

diphosphoglycerate (P <0.04) compared with controls. Multiple

regression analysis found methaemoglobin to be the principal

component that differentiated between CFS patients and control

subjects.

Methaemoglobin was found to be the major component associated with

variation in symptom expression in CFS patients (R(2) = 0.99, P

<0.00001), which included fatigue, musculoskeletal symptoms, pain

and sleep disturbance. Variation in levels of malondialdehyde and

2,3-diphosphoglycerate were associated with variations in cognitive

symptoms and sleep disturbance (R(2) = 0.99, P <0.00001). These data

suggest that oxidative stress due to excess free radical formation

is a contributor to the pathology of CFS and was associated with

symptom presentation.

PMID: 10905542 [PubMed - indexed for MEDLINE]