Re: Heprin inhibits growth of babesia

[Guest guest]

This is a very interesting article, and even more so in my case. I

have been recently diagnosed with Lyme. My LLMD felt though that

because of my past symptoms, Babesia was high on his list of

suspect. However, I was on heparin for 3 years and along with ABX

and antifungals have greatly improved. My coagulation is now normal.

Is my remission because of the heparin, the ABX, or the antifungals?

This thing about heparin and babesia really has me wondering.

>

>

>

> Just found this, another duel effect drug it seems ...

>

> Antimicrob Agents Chemother. 2004 Jan;48(1):236-41.

>

>

> Growth-inhibitory effect of heparin on Babesia parasites.

>

> Bork S, Yokoyama N, Ikehara Y, Kumar S, Sugimoto C, Igarashi I.

>

> National Research Center for Protozoan Diseases, Obihiro

University of

> Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido

080-8555,

> Japan.

>

>

>

> We examined the inhibitory effects of three heparins on the growth

of

> Babesia parasites. The multiplication of Babesia bovis, B.

bigemina, B.

> equi, and B. caballi in in vitro cultures and that of B. microti

in vivo

> were significantly inhibited in the presence of heparins, as

determined by

> light microscopy. Treatment with various concentrations of heparin

showed

> complete clearance of the intracellular parasites. Interestingly,

a higher

> percentage of abnormally multidividing B. bovis parasites was

observed in

> the presence of low concentrations of heparin. Furthermore,

fluorescein

> isothiocyanate-labeled heparin was preferably found on the

surfaces of

> extracellular merozoites, as detected by confocal laser scanning

microscopy.

> These findings indicate that the heparin covers the surfaces of

babesial

> merozoites and inhibits their subsequent invasion of erythrocytes.

> --

> No virus found in this outgoing message.

> Checked by AVG Anti-Virus.

> Version: 7.0.323 / Virus Database: 267.9.2/52 - Release Date:

19/07/2005

[Guest guest]

Too many variables.

We do alot of speculating here, and without specific testing and

tracking you'll never know for sure.

But since you're greatly improved, it's likely that it was the

effects of all three.

Barb

> >

> >

> >

> > Just found this, another duel effect drug it seems ...

> >

> > Antimicrob Agents Chemother. 2004 Jan;48(1):236-41.

> >

> >

> > Growth-inhibitory effect of heparin on Babesia parasites.

> >

> > Bork S, Yokoyama N, Ikehara Y, Kumar S, Sugimoto C, Igarashi I.

> >

> > National Research Center for Protozoan Diseases, Obihiro

> University of

> > Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido

> 080-8555,

> > Japan.

> >

> >

> >

> > We examined the inhibitory effects of three heparins on the

growth

> of

> > Babesia parasites. The multiplication of Babesia bovis, B.

> bigemina, B.

> > equi, and B. caballi in in vitro cultures and that of B. microti

> in vivo

> > were significantly inhibited in the presence of heparins, as

> determined by

> > light microscopy. Treatment with various concentrations of

heparin

> showed

> > complete clearance of the intracellular parasites. Interestingly,

> a higher

> > percentage of abnormally multidividing B. bovis parasites was

> observed in

> > the presence of low concentrations of heparin. Furthermore,

> fluorescein

> > isothiocyanate-labeled heparin was preferably found on the

> surfaces of

> > extracellular merozoites, as detected by confocal laser scanning

> microscopy.

> > These findings indicate that the heparin covers the surfaces of

> babesial

> > merozoites and inhibits their subsequent invasion of erythrocytes.

> > --

> > No virus found in this outgoing message.

> > Checked by AVG Anti-Virus.

> > Version: 7.0.323 / Virus Database: 267.9.2/52 - Release Date:

> 19/07/2005

[Guest guest]

That's a VERY interesting finding, J!

My short list of things which we have reason to believe can help

defeat Babesiosis just got longer.

There's the conventional treatments, the least toxic of which appear

to be Mepron + Macrolide and/or Malarone.

There's artemesin, which many seem to have luck with, including some

who have not improved on or been unable to tolerate the convential

treatments.

There's evidence from the p. falcicrum studies that remedying DHEA

and testosterone deficiency can make the difference between relapse

and recovery on any of the above regimens.

Now we have Heparin - and a keen interest on my part in learning

whether other anticoagulants that might be more accessible or

perceived as more safe share this anti-Babesial affect.

Guys and gals, anything else I should have on this list?

S.

>

>

>

> Just found this, another duel effect drug it seems ...

>

> Antimicrob Agents Chemother. 2004 Jan;48(1):236-41.

>

>

> Growth-inhibitory effect of heparin on Babesia parasites.

>

> Bork S, Yokoyama N, Ikehara Y, Kumar S, Sugimoto C, Igarashi I.

>

> National Research Center for Protozoan Diseases, Obihiro

University of

> Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido

080-8555,

> Japan.

>

>

>

> We examined the inhibitory effects of three heparins on the growth

of

> Babesia parasites. The multiplication of Babesia bovis, B.

bigemina, B.

> equi, and B. caballi in in vitro cultures and that of B. microti

in vivo

> were significantly inhibited in the presence of heparins, as

determined by

> light microscopy. Treatment with various concentrations of heparin

showed

> complete clearance of the intracellular parasites. Interestingly,

a higher

> percentage of abnormally multidividing B. bovis parasites was

observed in

> the presence of low concentrations of heparin. Furthermore,

fluorescein

> isothiocyanate-labeled heparin was preferably found on the

surfaces of

> extracellular merozoites, as detected by confocal laser scanning

microscopy.

> These findings indicate that the heparin covers the surfaces of

babesial

> merozoites and inhibits their subsequent invasion of erythrocytes.

> --

> No virus found in this outgoing message.

> Checked by AVG Anti-Virus.

> Version: 7.0.323 / Virus Database: 267.9.2/52 - Release Date:

19/07/2005