Clarifications on 1,25-D

[Guest guest]

Ken's post cites what is actually a well known set of facts, but

does a bang-up job of relating them together.

Too little vitamin D can cause PTH to spike (and too much PTH is the

leading cause of hypercalcemia). To avoid hypercalcemia, the body

produces more 1,25-D, which tells the parathyroid glands to ease up.

If you start taking 25-D, you get rid of the PTH problem, and the

body no longer has to send that signal. I admit it, I haven't read

the full paper yet, but it sure sounds like that sequence in the

portion Ken quoted for us.

It would never be a universally valid result. One can develop

hyperplasia of the parathyroid glands, in which case nothing will

stop the buggers from pumping out excess PTH and threatening us with

osteoporosis. Since we have four of them, the usual thing is to

remove the one that's overgrown it's britches. Jelly, have you had

your PTH tested?

One can be in the most active stage of Sarc, in which case (see

Scadding's study, cited by the MP's creator) one will not be able to

tolerate D at all, and if Lemiere is right it would be useless to

take it, even if one could, because the problem is a re-conversion

failure which supplementing with D will not fix.

But what Ken's post emphasizes is that you can have what the mp site

calls an abnormal " D-ratio " without it having a damn thing to do

with inflammation, simply by virtue of the interrelatedness of 25-D,

1,25-D, and PTH - and that " elevated 1,25-D " can indeed be a symptom

of deficiency of the precursor vitamin.

I think the clearest, most certain meaning of Ken's post is that

unless we are dealing with ACUTE hypercalcemia, and none of the more

common culprits seem to be present, testing serum 1,25-D is pretty

much a waste of time. Even then, it's not clear to me that the

measure will be much help, given the poor reliability of the test

and the impact of variables like menses on the result.

Thumbs up to Jill for recalling Scaddings study, and even getting

the numbers right. Yep, 6 of 9 Sarcoidosis patients could tolerate

vitamin D, took it, and improved or went into remission. 3 of 9

couldn't tolerate it at all - and as Pippit says, at that point it's

pretty much a no-brainer, you listen to your body, and when it

says " don't DO that, you don't do that. " But don't determine that by

way of sun or food, take the damn supplement so you know what it is

you're reacting to.

[Guest guest]

No , I don't think I have ever had my PTH tested, but then I

don't know maybe I have. But at the risk of showing my dumby side, I

don't even know what the Parathyroid is, and we have 4 of them????

My thyroid has always been normal so I always ingnored it any other

words involving thyroid.

But if I got what you are saying, my Ds might be high due to an

overactive Parathyroid? I've only just start following this thread a

little. Can you shut the Parathyroid down if it is overactive? One

thing that sticks with me from that other protocol is the

hypercalcemia.

> Ken's post cites what is actually a well known set of facts, but

> does a bang-up job of relating them together.

>

> Too little vitamin D can cause PTH to spike (and too much PTH is

the

> leading cause of hypercalcemia). To avoid hypercalcemia, the body

> produces more 1,25-D, which tells the parathyroid glands to ease

up.

> If you start taking 25-D, you get rid of the PTH problem, and the

> body no longer has to send that signal. I admit it, I haven't read

> the full paper yet, but it sure sounds like that sequence in the

> portion Ken quoted for us.

>

> It would never be a universally valid result. One can develop

> hyperplasia of the parathyroid glands, in which case nothing will

> stop the buggers from pumping out excess PTH and threatening us

with

> osteoporosis. Since we have four of them, the usual thing is to

> remove the one that's overgrown it's britches. Jelly, have you had

> your PTH tested?

>

> One can be in the most active stage of Sarc, in which case (see

> Scadding's study, cited by the MP's creator) one will not be able

to

> tolerate D at all, and if Lemiere is right it would be useless to

> take it, even if one could, because the problem is a re-conversion

> failure which supplementing with D will not fix.

>

> But what Ken's post emphasizes is that you can have what the mp

site

> calls an abnormal " D-ratio " without it having a damn thing to do

> with inflammation, simply by virtue of the interrelatedness of 25-

D,

> 1,25-D, and PTH - and that " elevated 1,25-D " can indeed be a

symptom

> of deficiency of the precursor vitamin.

>

> I think the clearest, most certain meaning of Ken's post is that

> unless we are dealing with ACUTE hypercalcemia, and none of the

more

> common culprits seem to be present, testing serum 1,25-D is pretty

> much a waste of time. Even then, it's not clear to me that the

> measure will be much help, given the poor reliability of the test

> and the impact of variables like menses on the result.

>

> Thumbs up to Jill for recalling Scaddings study, and even getting

> the numbers right. Yep, 6 of 9 Sarcoidosis patients could tolerate

> vitamin D, took it, and improved or went into remission. 3 of 9

> couldn't tolerate it at all - and as Pippit says, at that point

it's

> pretty much a no-brainer, you listen to your body, and when it

> says " don't DO that, you don't do that. " But don't determine that

by

> way of sun or food, take the damn supplement so you know what it

is

> you're reacting to.

>

>

[Guest guest]

For What It may help:

* hypercalcemia

--> Salt and C may help

" Replacing ongoing sodium, potassium, chloride, and magnesium

losses "

http://www.emedicine.com/med/topic1068.htm

PTH Connection:

" A person with primary hyperparathyroidism who also has borderline

nutritional status may develop deficiencies in the following

substances that are necessary for normal bone formation: Vitamin C,

Vitamin K, Manganese. " http://www.diagnose-me.com/cond/C647970.html

A possible herb is:

Horsetail Grass (Equisetum arvense) Horsetail is rich in minerals

and has been used in traditional remedies to support normal bone

integrity.

One

> thing that sticks with me from that other protocol is the

> hypercalcemia.