The Genome Sequence of Rickettsia felis Identifies the First Putative Conjugative Plasmid in an Obligate Intracellular Parasite.

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Au dessus de ma tête mais certainement intéressant et important."Votre ami Raoult" réussit à être ds tous les bons coups, décidément, pas lui qui se coltinerait tous ces cinglés de malades chroniques!

Accès direct à l'article complet et avec photos

Nelly P.

Bonnes vacances

http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed & pubmedid=15984913

PLoS Biol. 2005 Jul 5;3(8):e248 [Epub ahead of print]

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The Genome Sequence of Rickettsia felis Identifies the First Putative Conjugative Plasmid in an Obligate Intracellular Parasite.Ogata H, Renesto P, Audic S, C, Blanc G, Fournier PE, Parinello H, Claverie JM, Raoult D.Structural and Genomic Information Laboratory, UPR 2589, IBSM, CNRS, Marseille Cedex, France.We sequenced the genome of Rickettsia felis, a flea-associated obligate intracellular alpha-proteobacterium causing spotted fever in humans. Besides a circular chromosome of 1,485,148 bp, R. felis exhibits the first putative conjugative plasmid identified among obligate intracellular bacteria. This plasmid is found in a short (39,263 bp) and a long (62,829 bp) form. R. felis contrasts with previously sequenced Rickettsia in terms of many other features, including a number of transposases, several chromosomal toxin-antitoxin genes, many more spoT genes, and a very large number of ankyrin- and tetratricopeptide-motif-containing genes. Host-invasion-related genes for patatin and RickA were found. Several phenotypes predicted from genome analysis were experimentally tested: conjugative pili and mating were observed, as well as beta-lactamase activity, actin-polymerization-driven mobility, and hemolytic properties. Our study demonstrates that complete genome sequencing is the fastest approach to reveal phenotypic characters of recently cultured obligate intracellular bacteria.PMID: 15984913 [PubMed - as supplied by publisher]

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Sorry, meant for someone else here in France not for the list, got mixed up with addresses

Nelly

[infections] The Genome Sequence of Rickettsia felis Identifies the First Putative Conjugative Plasmid in an Obligate Intracellular Parasite.

Au dessus de ma tête mais certainement intéressant et important."Votre ami Raoult" réussit à être ds tous les bons coups, décidément, pas lui qui se coltinerait tous ces cinglés de malades chroniques!

Accès direct à l'article complet et avec photos

Nelly P.

Bonnes vacances

http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed & pubmedid=15984913