Protective Effects of Mild Hyopthermia in Endotoxemia

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Clin Diagn Lab Immunol. 2003 Sep;10(5):940-3. Related Articles,

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Effects of hypothermia on mortality and inflammatory responses to

endotoxin-induced shock in rats.

Taniguchi T, Kanakura H, Takemoto Y, Yamamoto K.

Department of Emergency and Critical Care Medicine, Graduate School

of Medical Science, Kanazawa University Graduate School of Medical

Science, Kanazawa University, Kanazawa 920-8641, Japan.

taniyan@...

We studied the effects of hypothermia on mortality rate,

concentrations of tumor necrosis factor alpha and interleukin 6 in

plasma, and the end products of nitric oxide (NO) in endotoxemia. It

was found that moderate and mild hypothermia improved the mortality

rate and attenuated cytokine responses and the elevation of the end

products of NO after endotoxin injection and that these beneficial

effects were similar for moderate and mild hypothermia.

PMID: 12965930 [PubMed - indexed for MEDLINE]