Re: HCQ/ tini interactions was Porphyria, Stratton, etc

[Guest guest]

>

> Most drugs that use the P450 system for metabolism are thought to

use

> one pathway. But there are some drugs (called substrates) that

use

> multiple path ways. There are also drugs called 'inhibitors' ,

that

> hinibit one path way, which in turn can raise the consentration

> levels of another drug that wants to use that same pathway for

it's

> metabolism. An 'inducer' will cause faster clearance of a drug

that

> uses the same pathway(s).

>

> HCQ is classified as an inhibitor of cyp2d6 inhibitor, and a

> substrate for cyp3A4 and 2D8. (And since these have only

classifed

> recently, I bet there's more).

>

> There isn't much in the lit about Tini - but it's a close relative

to

> metronidazole- which shouldn't interact with HCQ- but you can't be

> certain, becuase it's NOT exactly the same.

>

> It might be like DOxy and HCQ - for which there's not problems-

but

> with HCQ and Mino there sure is a reaction (and I'm pretty sure

HCQ

> causes higher consentrations of Mino in the body, because I had to

> decreas the HCQ or I had Mino toxicity effects (and I can normally

> take 200mg Mino a day till the cows come home - and I can noramlly

> take very high doses of HCQ as a mono therapy without side

effects.).

>

> So- just becarefull and be aware that HCQ can interact with alot

of

> drugs becuase it uses (or inhibits) multiple P450 pathways.

>

> Barb

Hi Barb

Just to reinforce what you have said about HCQ, I got a really bad

drug reaction when I first took Diflucan and I had been on HCQ with

erythromycin for 6 weeks. I had severe migraines and auras that

affected my nervous system so badly it took me 2 1/2 weeks to get

over them. It is great that you draw people's attention to these

drug interractions because the effect can make one feel dreadful.

I left it 3 weeks before I restarted the Diflucan and have never had

the auras since though I still tend to get migraines on it

especially if I eat chocolate!

Pam