Cranberry Juice enhances aspirin consentrations

[Guest guest]

J Agric Food Chem. 2005 Apr 20;53(8):2897-900

Increased salicylate concentrations in urine of human volunteers

after consumption of cranberry juice.

Duthie GG, JA, on AM, Duthie SJ, Baxter GJ, Paterson JR.

Rowett Research Institute, Aberdeen AB21 9SB, Scotland, UK.

ggd@...

The aim of this study was to assess whether regular consumption of

cranberry juice results in elevations in urinary salicylate

concentrations in persons not taking salicylate drugs. Two groups of

healthy female subjects (11/group) matched for age, weight, and

height consumed 250 mL of either cranberry juice or a placebo

solution three times a day (i.e., 750 mL/day) for 2 weeks. At weekly

intervals, salicylic acid and salicyluric acid (the major urinary

metabolite of salicylic acid) concentrations were determined in urine

by HPLC with electrochemical detection. Concentrations of salicylic

acid in plasma were also determined. Consumption of cranberry juice

was associated with a marked increase (p < 0.001) of salicyluric and

salicylic acids in urine within 1 week of the intervention. After 2

weeks, there was also a small but significant (p < 0.05) increase in

salicylic acid in plasma.

The regular consumption of cranberry juice results in the

increased absorption of salicylic acid, an anti-inflammatory compound

that may benefit health.

__________________________________________________________________

Helicobacter. 2005 Apr;10(2):139-45. Related Articles, Links

Efficacy of cranberry juice on Helicobacter pylori infection: a

double-blind, randomized placebo-controlled trial.

Zhang L, Ma J, Pan K, Go VL, Chen J, You WC.

School of Oncology, Peking University, Beijing Institute for Cancer

Research, China.

BACKGROUND: Helicobacter pylori infection is a major cause of peptic

ulcer disease and gastric cancer. This study postulated that

cranberry juice would be effective in the suppression of H. pylori in

an endemically infected population at high risk for gastric cancer.

MATERIALS AND METHODS: A prospective, randomized, double-blind,

placebo-controlled trial was conducted in Linqu County of Shandong

Province, China, where 189 adults aged 48.9 +/- 11.2 years (mean +/-

SD) with H. pylori infection were randomly divided into two groups:

cranberry juice (n = 97) and placebo (n = 92). Participants were

assigned to orally receive two 250-ml juice boxes of cranberry juice

or matching placebo beverage daily for 90 days. The degree of H.

pylori infection was determined using the 13C-urea breath test before

randomization at 35 and 90 days of intervention to assess the

efficacy of cranberry juice in alleviating infection. RESULTS: A

total of 189 subjects with positive 13C-urea breath test results

prior to randomization completed the study. At day 35 of

intervention, 14 of the 97 (14.43%) from the the cranberry juice

treatment group and 5 of the 92 (5.44%) of the placebo recipients had

negative 13C-urea breath test results. After 90 days, the study

concluded that 14 of the 97 subjects in the cranberry juice treatment

group versus 5 of the 92 in the placebo group yielded negative test

results. Eleven individuals from the cranberry juice treatment group

and only two from the placebo group were negative at 35 and 90 days

of experiment.

These results are significant (p < .05). CONCLUSIONS: Regular

consumption of cranberry juice can suppress H. pylori infection in

endemically afflicted populations.

PMID: 15810945 [PubMed - in process]

[Guest guest]

Very interesting, and coincidenatlly, I've been drinking a lot of

cranberry (usually mixed with blackberry) juice for a couple of

months now. I mix it half and half with sparkling mineral water.

Maybe that's contributing to my improved health as well?

Thanks, Barb.

penny

> J Agric Food Chem. 2005 Apr 20;53(8):2897-900

>

> Increased salicylate concentrations in urine of human volunteers

> after consumption of cranberry juice.

>

> Duthie GG, JA, on AM, Duthie SJ, Baxter GJ, Paterson

JR.

>

> Rowett Research Institute, Aberdeen AB21 9SB, Scotland, UK.

> ggd@r...

>

> The aim of this study was to assess whether regular consumption of

> cranberry juice results in elevations in urinary salicylate

> concentrations in persons not taking salicylate drugs. Two groups

of

> healthy female subjects (11/group) matched for age, weight, and

> height consumed 250 mL of either cranberry juice or a placebo

> solution three times a day (i.e., 750 mL/day) for 2 weeks. At

weekly

> intervals, salicylic acid and salicyluric acid (the major urinary

> metabolite of salicylic acid) concentrations were determined in

urine

> by HPLC with electrochemical detection. Concentrations of

salicylic

> acid in plasma were also determined. Consumption of cranberry

juice

> was associated with a marked increase (p < 0.001) of salicyluric

and

> salicylic acids in urine within 1 week of the intervention. After

2

> weeks, there was also a small but significant (p < 0.05) increase

in

> salicylic acid in plasma.

> The regular consumption of cranberry juice results in the

> increased absorption of salicylic acid, an anti-inflammatory

compound

> that may benefit health.

>

>

> __________________________________________________________________

> Helicobacter. 2005 Apr;10(2):139-45. Related Articles, Links

>

> Efficacy of cranberry juice on Helicobacter pylori infection: a

> double-blind, randomized placebo-controlled trial.

>

> Zhang L, Ma J, Pan K, Go VL, Chen J, You WC.

>

> School of Oncology, Peking University, Beijing Institute for

Cancer

> Research, China.

>

> BACKGROUND: Helicobacter pylori infection is a major cause of

peptic

> ulcer disease and gastric cancer. This study postulated that

> cranberry juice would be effective in the suppression of H. pylori

in

> an endemically infected population at high risk for gastric

cancer.

> MATERIALS AND METHODS: A prospective, randomized, double-blind,

> placebo-controlled trial was conducted in Linqu County of Shandong

> Province, China, where 189 adults aged 48.9 +/- 11.2 years (mean

+/-

> SD) with H. pylori infection were randomly divided into two

groups:

> cranberry juice (n = 97) and placebo (n = 92). Participants were

> assigned to orally receive two 250-ml juice boxes of cranberry

juice

> or matching placebo beverage daily for 90 days. The degree of H.

> pylori infection was determined using the 13C-urea breath test

before

> randomization at 35 and 90 days of intervention to assess the

> efficacy of cranberry juice in alleviating infection. RESULTS: A

> total of 189 subjects with positive 13C-urea breath test results

> prior to randomization completed the study. At day 35 of

> intervention, 14 of the 97 (14.43%) from the the cranberry juice

> treatment group and 5 of the 92 (5.44%) of the placebo recipients

had

> negative 13C-urea breath test results. After 90 days, the study

> concluded that 14 of the 97 subjects in the cranberry juice

treatment

> group versus 5 of the 92 in the placebo group yielded negative

test

> results. Eleven individuals from the cranberry juice treatment

group

> and only two from the placebo group were negative at 35 and 90

days

> of experiment.

>

> These results are significant (p < .05). CONCLUSIONS: Regular

> consumption of cranberry juice can suppress H. pylori infection in

> endemically afflicted populations.

>

> PMID: 15810945 [PubMed - in process]