Re: Nelly & Penny re: C. Pneumonia and MRSA

[Guest guest]

Funny. I've been reading about this abx, which has been around

forever (also called Macrodantin) and given for UTIs.

See reference 2, as this abx can be toxic to DNA-

So I'm not sure I'd want to take this long-term (The double edged

sword you know)

REFERENCE 1

Surg Infect (Larchmt). 2005 Spring;6(1):87-92.

Emerging infections with community-associated methicillin-resistant

Staphylococcus aureus in outpatients at an Army Community Hospital.

Beilman GJ, Sandifer G, Skarda D, Jensen B, McAllister S, Killgore G,

Srinivasan A.

Division of Surgical Critical Care, Department of Surgery, University

of Minnesota, Minneapolis, Minnesota 55455, USA. beilm001@...

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA)

infection typically occurs in chronically ill patients requiring long-

term antimicrobial therapy or hospitalization. However, community-

associated MRSA (CA-MRSA) necrotizing soft tissue infections seem to

be increasing in incidence. Our aim was to describe the incidence and

microbiologic characteristics of CA-MRSA isolates collected at an

army community hospital. METHODS: We report a retrospective review of

MRSA isolates identified during 1998-2003 at the microbiology

laboratory of Moncrief Army Community Hospital that serves a

community of approximately 40,000 transient residents yearly in Fort

, South Carolina. We evaluated the incidence of MRSA in our

laboratory during 1998-2003. For MRSA isolates from 2003, we

evaluated antimicrobial susceptibility patterns. Six selected

isolates were evaluated by molecular typing, resistance gene

analysis, and toxin analysis. RESULTS: During 1998-2003, 241 (23%) of

1041 S. aureus isolates identified at the hospital microbiology

laboratory were resistant to methicillin. Of these 241 MRSA isolates,

223 were cultured from outpatients. The incidence of MRSA in our

population increased from 12% of S. aureus isolates in 1998 to 43% in

2003. In 2003, MRSA was cultured from 76 different patients. Isolates

of MRSA were often resistant to erythromycin (91%), although

resistance to other agents was less common: Ciprofloxacin (14%),

levofloxacin (14%), clindamycin (3%), tetracycline (3%), and

trimethoprim sulfamethoxazole (1%).

No isolates were resistant to vancomycin, gentamicin, nitrofurantoin,

or rifampin. Six CA-MRSA isolates were compared by pulsed-field gel

electrophoresis (PFGE).

Five were PFGE type USA300, and one was PFGE type USA100, based on

the U.S. Centers for Disease Control and Prevention (CDC)

classification scheme. The five USA300 isolates carried SCCmec type

IV, and the USA100 carried SCCmec II. None of the isolates were

positive by PCR for genes encoding enterotoxins A-E and H, or toxic

shock syndrome toxin (TSST-1), but the five USA300 isolates carried

the gene coding for Panton-Valentine leukocidin toxin. CONCLUSIONS:

The incidence of MRSA at our institution is increasing. Isolates of

MRSA show resistance patterns and microbiologic characteristics

consistent with CA-MRSA isolates from the United States. Clinicians

should consider the possibility of CA-MRSA in patients with soft-

tissue infections who do not respond to initial therapy with beta-

lactam antimicrobial agents.

PMID: 15865554 [PubMed - in process]

____________________________________________________________________

REFERENCE 2

Mutagenesis. 2005 May;20(3):193-7. Epub 2005 Apr

Comparative genotoxic evaluation of 2-furylethylenes and 5-

nitrofurans by using the comet assay in TK6 cells.

Borroto JI, Machado G, Creus A, Marcos R.

Grup de Mutagenesi, Departament de Genetica i de Microbiologia,

Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193

Bellaterra, Spain.

The genotoxicity of three 2-furylethylene derivatives and four 5-

nitrofurans was evaluated by using the comet assay in human

lymphoblastoid cultured TK6 cells. The 2-furylethylene derivatives

were 2-furyl-1-nitroethene, 1-(5-bromofur-2-yl)-2-nitroethene and 1-

(5-bromofur-2-yl)-2-bromo-2-nitroethene, while the 5-nitrofurans were

nitrofurantoin, nitrofurazone, furazolidone and 5-nitro-2-

furanacrolein. The treatments lasted for 3 h in the absence of

metabolic activation. No genotoxic effects were observed for two of

the 2-furylethylene compounds, while the derivative 1-(5-bromofur-2-

yl)-2-nitroethene showed a statistically significant response mainly

at the highest concentration tested; this effect was considered

biologically relevant and the compound was classified as slightly

genotoxic. On the other hand, for the classical 5-nitrofurans tested

there is a tendency towards a dose-related increase of the DNA damage

in the comet assay and the observed increases for the parameters

analysed (Olive tail moment, tail % DNA and tail length) were

significant for all compounds. Then, the four 5-nitrofurans tested

were considered genotoxic. These results show that the position of

the nitro group influences the genotoxicity of the assayed compounds.

Thus, in this comet assay, the 2-furylethylene derivatives having the

nitro group attached outside the furan ring appear to be much less

genotoxic than the 5-nitrofurans.

PMID: 15817571 [PubMed - in process]

>

> >> Yes Penny, I have been using a Wheldon/Stratton

> protocol for

>

> several months this time but I had used some

> components of it in the

> past. I am using as much of the protocol as I can, as

> I have had to

> also re-introduce mefloquine (lariam) for Babesia bec

> of returning

> heart sxs.

>

> >>

> >> The cycline + macrolide part of the protocol is

> quite easy to take

>

> and I am quite sure it is getting some job done (much

> better sleep

> and a kind of loosening of tensions in head) but the

> intro of the

> imidazole has rocked me quite hard even when using it

> only a few

> days in a row. It is quite interesting as I have used

> loads od

> tinidazole before but not in the same context ie after

> a few weeks

> on a cycline + macrolide regimen.

>

> >>

> >> I have also started taking the charcoal part of it

> more seriously

>

> lately taking quite a big scoop at night (not sure how

> much I am

> taking, probably btwn 5-10g per evening)

>

> >>

> >> I am taking sublingual B12 but no cimetidine

> >>

> >> Nelly

> >>

[Guest guest]

Barb

Macrodantin is a useless antibiotic because it does nothing in the

body. It kills bugs in the urine only.It fails to change any aspect

of systemic disease. I did notice that they had this antimicrobial

cream for external application whihc is only available in the vet

circles nowadays.

I absolutely feel this drug is unbeleivable because it keeps killing

bacteria which other abx don't touch.Unfortunately in blood plasma

USELESS - NO EFFECT on bacteria.

tony

> >

> > >> Yes Penny, I have been using a Wheldon/Stratton

> > protocol for

> >

> > several months this time but I had used some

> > components of it in the

> > past. I am using as much of the protocol as I can, as

> > I have had to

> > also re-introduce mefloquine (lariam) for Babesia bec

> > of returning

> > heart sxs.

> >

> > >>

> > >> The cycline + macrolide part of the protocol is

> > quite easy to take

> >

> > and I am quite sure it is getting some job done (much

> > better sleep

> > and a kind of loosening of tensions in head) but the

> > intro of the

> > imidazole has rocked me quite hard even when using it

> > only a few

> > days in a row. It is quite interesting as I have used

> > loads od

> > tinidazole before but not in the same context ie after

> > a few weeks

> > on a cycline + macrolide regimen.

> >

> > >>

> > >> I have also started taking the charcoal part of it

> > more seriously

> >

> > lately taking quite a big scoop at night (not sure how

> > much I am

> > taking, probably btwn 5-10g per evening)

> >

> > >>

> > >> I am taking sublingual B12 but no cimetidine

> > >>

> > >> Nelly

> > >>

[Guest guest]

It does do a good job on UTIs that don't respond to Cipro and Zith.

I know 2 people who recently used it after using those others.

Have you ever used it in your culture plates?

And maybe it would be a good abx if combined with another (sometimes

2 work together when one or the other doens't work alone.

Barb

> > >

> > > >> Yes Penny, I have been using a Wheldon/Stratton

> > > protocol for

> > >

> > > several months this time but I had used some

> > > components of it in the

> > > past. I am using as much of the protocol as I can, as

> > > I have had to

> > > also re-introduce mefloquine (lariam) for Babesia bec

> > > of returning

> > > heart sxs.

> > >

> > > >>

> > > >> The cycline + macrolide part of the protocol is

> > > quite easy to take

> > >

> > > and I am quite sure it is getting some job done (much

> > > better sleep

> > > and a kind of loosening of tensions in head) but the

> > > intro of the

> > > imidazole has rocked me quite hard even when using it

> > > only a few

> > > days in a row. It is quite interesting as I have used

> > > loads od

> > > tinidazole before but not in the same context ie after

> > > a few weeks

> > > on a cycline + macrolide regimen.

> > >

> > > >>

> > > >> I have also started taking the charcoal part of it

> > > more seriously

> > >

> > > lately taking quite a big scoop at night (not sure how

> > > much I am

> > > taking, probably btwn 5-10g per evening)

> > >

> > > >>

> > > >> I am taking sublingual B12 but no cimetidine

> > > >>

> > > >> Nelly

> > > >>

[Guest guest]

Barb

Have I used it... Ask Penny how often I would say macrodantin keeps

on keeping on. I would suck on these all day to try and reduce my

oral flora.

The thing I'm coming around to discover is that we are m,issing last

centuries wonder drug in our treatments. Penicillin even though

frequently listed as resistant in most tests the bacteria even

though they possess beta lactams that beat the penicillin if dosed

correctly this drug still penetrates and cuts down bacteria better

than any other abx.

I also believe if you use it blown out of an asthma pump ythe oxygen

molecules will keep the bacteria fromn producing there beta

lactams.Bacteria need a certain amount of CO2 they have mecahnisms

on borad which enable them to produce there own requirements so they

can do there dirty work.

I'm working with penicillin because no-one in the hospital system

can become well without this drug covering more than what it's

touted for.I also believe it's one of very few drugs that kills

exisiting microbes wheras most abx only stop the infection getting

larger.

> > > >

> > > > >> Yes Penny, I have been using a Wheldon/Stratton

> > > > protocol for

> > > >

> > > > several months this time but I had used some

> > > > components of it in the

> > > > past. I am using as much of the protocol as I can, as

> > > > I have had to

> > > > also re-introduce mefloquine (lariam) for Babesia bec

> > > > of returning

> > > > heart sxs.

> > > >

> > > > >>

> > > > >> The cycline + macrolide part of the protocol is

> > > > quite easy to take

> > > >

> > > > and I am quite sure it is getting some job done (much

> > > > better sleep

> > > > and a kind of loosening of tensions in head) but the

> > > > intro of the

> > > > imidazole has rocked me quite hard even when using it

> > > > only a few

> > > > days in a row. It is quite interesting as I have used

> > > > loads od

> > > > tinidazole before but not in the same context ie after

> > > > a few weeks

> > > > on a cycline + macrolide regimen.

> > > >

> > > > >>

> > > > >> I have also started taking the charcoal part of it

> > > > more seriously

> > > >

> > > > lately taking quite a big scoop at night (not sure how

> > > > much I am

> > > > taking, probably btwn 5-10g per evening)

> > > >

> > > > >>

> > > > >> I am taking sublingual B12 but no cimetidine

> > > > >>

> > > > >> Nelly

> > > > >>