Re: Wheldon's comments on abx choices

[Guest guest]

if you need any tec help with that jim just let me know

bleu

[infections] Wheldon's comments on abx choices

Below are Wheldon's comments on his choices ofabx for treating Cpn. i sent him Nelly's questions(with her name removed of course, plus a few of myown.There's also some interesting discussion of Cpntreatment on the This Is MS forum, including the lastVanderbilt study.I'm now contemplating putting up a web page that hasall the Cpn treatment and research stuff gathered inone place, perhaps snippets of discussion from siteslike ours as well. I have found most info is orientedtowards a specific illness (like MS) and yet thisorganism is implicated in so many other things. Not atask I need to take on these days, but maybe worthdoing. If you folks send me any links or other infoyou have, I'll start collecting it.Jim-------Jim -Thanks for your letter. You certainly cover somesalient points.I believe that Stratton and co-workers used abeta-lactam (penicillin, amoxycillin or similar) toattack the infectious stage (elementary body) of theorganism. They did some in vitro work to support this,which they should publish, because it's fundamental. Ireasoned that, as culture was so rare in persistenthuman infections, the numbers of elementary bodieswould be small. Also, any elementary body entering aphagosome in a cell containing bacterialprotein-synthesis inhibitors would be doomed, as theorganism needs to fabricate proteins immediately tosurvive. Coupled with this was a native gut-reactionthat people would buy into the idea more readily ifthere were fewer antibiotics. And, further, that oneis taught at med school never to combine cidal andstatic agents. In the higher levels of microbiologythat's not always true, but basically you just wantpeople to believe you and treat, as early as possible,and the more complications you put in their way themore difficult that is.In fine, I think that mangling the organism andexposing all its components to the immune system forrecognition, and purging the immune cells(lymphocytes, macrophages and monocytes) of theorganism is enough. You don't need to kill every lastorganism. Just halt bacterial protein synthesis, forcethe bacterium into a non-oxidative mode, then damageits DNA with metronidazole while it is unable torepair it. You want a situation like the opening sceneof Polanski's Macbeth. After treatment you might wantto keep in with an intermittent maintenance therapy,but to be honest I think clearing the immune systemand exposure of the organism is probably enough.Have I sent you a draft of our paper on this? If not,I'll send you one.best wishes,-----------

[Guest guest]

> I'm now contemplating putting up a web page that has

> all the Cpn treatment and research stuff gathered in

> one place, perhaps snippets of discussion from sites

> like ours as well.

Go for it, Jim! That would be really helpful.

- Kate