Guest guest Posted June 22, 2005 Report Share Posted June 22, 2005 Hi Jerry: You have made several points (as you have in the past) that fits nicely with either my observations of sick animals, my own illness, and my observations of an apparent dependance on antibiotics (after long term use). We have discussed this before - but I'm glad you brought it up again: JERRY WROTE: As I have said before, my own opinion is that the inappropriate brain functioning is actually an inherited, pre-conditioned " hibernation response " as a result of the immune system discovering a infection. BARB replies: If we observ our animals - domestic or wild - this is exactly what they do. They iiediately hunger down, lick their wounds and sleep. What do we humans do? Quite the opposite. JERRY WROTE: The above discussion of antibiotics reveals the ways in which for some folks abx's may interfere with the brain's inappropriate functioning, and relieve some patients of most of those symptoms associated with the 'hibernation response'. BARB REPLIES: From my own observations with abx, and in discussions with others, I also think there is an adaptive or compensatory (brain) mechanism that occurs after some specific time on many abx, that for lack of a better word the abx becomes 'addictive' , therefore causing adverse symptoms when one quits them 'cold turkey'. And some of us may be more suseptible than others to certain abx. And for others, there may be more specific effects with brain chemistry as in my case with Doxycycline. Within 5 weeks of use, although obviously effective on my Lyme , it also started to give me nightmares, these progressed to night terrors in the classical sense, then progress to what I call Daymares (others may call it waking hallucinations) which were preceeded by a few seconds of extreem sleepiness (almost like narcolepsy), which I think was a change in brain wave. It was at this point I decided I needed to go off the Doxy, and found to my surprise (and thru trial and error) I had to WEAN off the stuff, or I experienced a myriad of symptoms (but symptoms of what?) if I stopped cold turkey. JERRY WROTE: The above discussion of antibiotics reveals the ways in which for some folks abx's may interfere with the brain's inappropriate functioning, and relieve some patients of most of those symptoms associated with the 'hibernation response'. The curative, final solution for most of us will be to follow Tony and Barb's lead of finding out what infections we are saddled with and the best way to eliminate them while using nutritional and lifestyle strategies designed to help overcome any likely genetic defects and/or results of long term illness (like the dreaded couchpotatoatosis). BARB REPLIES: My theory is that our own genetic make up (which can possibly be broken down into tissue type groupings) will determine how each group will present when challenged with a paticular pathogen or subsequent group of pathogens riding on the coat-tails of the primary. The genetic make up of the P450 system will determine how we react to the drugs (and drug combo's) that use this metabolic pathway. I look at it like guerilla war. Good intelligence and judicious use of weapons. I don't like a carpet bombing approach. Barb wrote: As I have said before, my own opinion is that the inappropriate brain functioning is actually an inherited, pre-conditioned " hibernation response " as a result of the immune system discovering a infection. Like the 'fight or flight' stress response. Almost all of our ancestors lived in small family or tribal units, and I see the 'hibernation response' as a survival strategy for both the group (high priority) and the individual (low priority). The families that had the best chance of survival were those who's members, when sick with a contagion, isolated themselves from the rest of the group. The very symptoms that we are burdened with; light sensitive with muscle weakness and pain, fatigue, no appetite or sex drive... These 'pains' are the enforcers of isolation, the protectors of group survival. We should not be amazed at just how debilitating these symptoms are, they are the result of many generations of our families surviving the plagues and other ravages of living in an environment full of creatures that like to make us their home. The difference between then and now is that now we are saddled with these symptoms chronically, whereas our ancestors either got well or died within weeks. And as the years wind on, we accumulate more symptoms that are not part of the 'hibernation response', but picked up as a result of inactivity and compromised immunity. To make a long story short, when I see a brain scan that shows hypoperfusion of the dorsolateral prefrontal cortex, I see that as evidence of an infection produced inflammatory immune response, with a good chance that there is a genetic flaw acting as a catalyst to keep one's brain in what today (thanks to abx, there are very few life threatening contagions around) is an inappropriate feedback loop. The above discussion of antibiotics reveals the ways in which for some folks abx's may interfere with the brain's inappropriate functioning, and relieve some patients of most of those symptoms associated with the 'hibernation response'. The curative, final solution for most of us will be to follow Tony and Barb's lead of finding out what infections we are saddled with and the best way to eliminate them while using nutritional and lifestyle strategies designed to help overcome any likely genetic defects and/or results of long term illness (like the dreaded couchpotatoatosis). Jerry > > > > > Geez. I really don't have the energy to be called to task and > > asked > > > to reproduce an entire conversation and besides I can't do that. > > > > > > I asked you to clarify the meaning of that portion of the > > conversation which you paraphrased to us. You referred to the > > rapidity with which Dr. Fallon's patients relapse following the > > discontinuation of Rocephin. > > > > You said, > > > > " Fallon seems to think (in conversation/interview) that > > patients may relapse so rapidly off rocephin because.... " > > > > So I asked you, > > > > " So I just want to clarify: he's not now saying that all his Lyme > > patients relapse rapidly following cessation of Rocephin, is he? " > > > > Since you are the one who talked to him about the rapidity with > > which his patients relapse following the discontinuation of > > Rocephin, I am asking you if he gave you some idea about the > > incidence of this problem. Do most of his patients relapse > > rapidly, or is this relatively uncommon? > > > > > > > Please refer to the Nature paper. I have nothing to clarify. > > > > > > The Nature paper did not report on how Dr. Fallon's patients > > respond to Rocephin. You did. That is why I asked you to clarify > > what you meant. > > > > It took only a couple of months for the NEJM to use the Nature > > paper to take a shot at Lyme activism (see my post #1328). The > > NEJM article states that the benefits that are seen with the use of > > Rocephin are being used by some people as evidence that > > certain patients indeed have Lyme. But the NEJM article uses > > that Nature paper to undermine that argument. Now you are > > reporting that Dr. Fallon has patients that relapse rapidly off > > Rocephin; too rapidly to be accounted for by a rebound in > > bacterial population. > > > > You appear then, by way of Dr. Fallon, to be lending weight to the > > NEJM's position. > > > > That's OK. But the next question is: how much credibility will > > Lyme patients lose if they do not address this issue proactively? > > A good fall-back position is for patients/LLMDs to say that, in > > accordance with the Nature paper and the criticism of Lyme > > activism that appears in the NEJM article, Rocephin may indeed > > be palliative by way of glutamate transport, but at least this > > demonstrates glutamate toxicity in patients that had been > > otherwise shunned by the medical community. That is, those in > > the medical establishment who shun sick people can not use > > the Nature paper to undermine the LLMDs that these patients > > turn to with out simultaneously acknowledging the glutamate > > toxicity occuring within the patients they (the conventional > > doctors) have abandoned. > > > > Lyme activists need to use the Nature paper to their own > > advantages, and not have it used against them. But that can't > > happen until we get clear on the extent to which Rocephin is > > palliative vs. curative. > > > > Matt Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2005 Report Share Posted June 22, 2005 Barb Just reading the last part about targeting as opposed to carpet bombing with abx. I just found that doing a penicillin for egs. early in the piece I would get one or two hours of relief followed by a 4 hour wait to get my next dose of pain relief.This was remedied by INCREASING THE DOSE. Unlike the other folk I stopped believeing stories when I observed this simple phenomena. More pain experienced... increase drug level, Increased drug level saw vein after vein after, sore rib, all slowly give up there pain and discomfort(infection).But this also paved the way into what's truly going on MASSIVE INFECTION as opposed to whimpy science and poor story telling.When your down with these conditions it's only capable of resolving if you take similar strategies to a smaller but identical infection " tuberculosis " .Could you imagine how silly some others look when trying to convince us that the tetrtacycline group can be used at 6 mg a day and the equivalent TB ilness when deciding to use this drug they give it at doses of 12 grams a day 1000 times more approx...than the supposed therapeutic crapola fed to us.Tetracyclines aren't used for TB but a study showed how they could be used... I can't recall but when used it was at the extreme level due to the seriousness of an infection that kills a couple of million a year. BArb You also are an extreme case because serious infections often see the person loose the spleen to eradicate the infection, so whjat works for you may not be appropriate for the spleened amongst us.This one is truly food for thought because your infections responded alot nicer to the same drug groups used by so many without your type of luck. tony > > > > > > > Geez. I really don't have the energy to be called to task and > > > asked > > > > to reproduce an entire conversation and besides I can't do that. > > > > > > > > > I asked you to clarify the meaning of that portion of the > > > conversation which you paraphrased to us. You referred to the > > > rapidity with which Dr. Fallon's patients relapse following the > > > discontinuation of Rocephin. > > > > > > You said, > > > > > > " Fallon seems to think (in conversation/interview) that > > > patients may relapse so rapidly off rocephin because.... " > > > > > > So I asked you, > > > > > > " So I just want to clarify: he's not now saying that all his Lyme > > > patients relapse rapidly following cessation of Rocephin, is he? " > > > > > > Since you are the one who talked to him about the rapidity with > > > which his patients relapse following the discontinuation of > > > Rocephin, I am asking you if he gave you some idea about the > > > incidence of this problem. Do most of his patients relapse > > > rapidly, or is this relatively uncommon? > > > > > > > > > > Please refer to the Nature paper. I have nothing to clarify. > > > > > > > > > The Nature paper did not report on how Dr. Fallon's patients > > > respond to Rocephin. You did. That is why I asked you to > clarify > > > what you meant. > > > > > > It took only a couple of months for the NEJM to use the Nature > > > paper to take a shot at Lyme activism (see my post #1328). The > > > NEJM article states that the benefits that are seen with the use > of > > > Rocephin are being used by some people as evidence that > > > certain patients indeed have Lyme. But the NEJM article uses > > > that Nature paper to undermine that argument. Now you are > > > reporting that Dr. Fallon has patients that relapse rapidly off > > > Rocephin; too rapidly to be accounted for by a rebound in > > > bacterial population. > > > > > > You appear then, by way of Dr. Fallon, to be lending weight to > the > > > NEJM's position. > > > > > > That's OK. But the next question is: how much credibility will > > > Lyme patients lose if they do not address this issue > proactively? > > > A good fall-back position is for patients/LLMDs to say that, in > > > accordance with the Nature paper and the criticism of Lyme > > > activism that appears in the NEJM article, Rocephin may indeed > > > be palliative by way of glutamate transport, but at least this > > > demonstrates glutamate toxicity in patients that had been > > > otherwise shunned by the medical community. That is, those in > > > the medical establishment who shun sick people can not use > > > the Nature paper to undermine the LLMDs that these patients > > > turn to with out simultaneously acknowledging the glutamate > > > toxicity occuring within the patients they (the conventional > > > doctors) have abandoned. > > > > > > Lyme activists need to use the Nature paper to their own > > > advantages, and not have it used against them. But that can't > > > happen until we get clear on the extent to which Rocephin is > > > palliative vs. curative. > > > > > > Matt Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2005 Report Share Posted June 22, 2005 Tony: As I wrote that sentence about selective weapons V carpet bombing- I thought about you, and thought I should clarify. I agree the dosages should be as high as possible when selectively choosing abx or abx combo's. What I meant about carpet bombing- was using chemical classes against the pathogens that are basically worthless - but damages the body. The Docs think that I may have splenic tissue splattered trough out my body cavity or an auxillary spleen attched to the pancreas (as that's mis-shappened) , as they said I should have died long ago otherwise. Because of my (internal) anatomy - I might not have the luxury of abx 'mistakes' others can make- and conversely, I may respond better to abx if I choose correctly. Barb PS... and I may not be an anomoly- how many people have had a full torso ring CATSCANs? There coupld be other people out there born without a spleen. I didn't even find this out until 2001. > > > > > > > > > Geez. I really don't have the energy to be called to task > and > > > > asked > > > > > to reproduce an entire conversation and besides I can't do > that. > > > > > > > > > > > > I asked you to clarify the meaning of that portion of the > > > > conversation which you paraphrased to us. You referred to the > > > > rapidity with which Dr. Fallon's patients relapse following > the > > > > discontinuation of Rocephin. > > > > > > > > You said, > > > > > > > > " Fallon seems to think (in conversation/interview) that > > > > patients may relapse so rapidly off rocephin because.... " > > > > > > > > So I asked you, > > > > > > > > " So I just want to clarify: he's not now saying that all his > Lyme > > > > patients relapse rapidly following cessation of Rocephin, is > he? " > > > > > > > > Since you are the one who talked to him about the rapidity > with > > > > which his patients relapse following the discontinuation of > > > > Rocephin, I am asking you if he gave you some idea about the > > > > incidence of this problem. Do most of his patients relapse > > > > rapidly, or is this relatively uncommon? > > > > > > > > > > > > > Please refer to the Nature paper. I have nothing to clarify. > > > > > > > > > > > > The Nature paper did not report on how Dr. Fallon's patients > > > > respond to Rocephin. You did. That is why I asked you to > > clarify > > > > what you meant. > > > > > > > > It took only a couple of months for the NEJM to use the Nature > > > > paper to take a shot at Lyme activism (see my post #1328). > The > > > > NEJM article states that the benefits that are seen with the > use > > of > > > > Rocephin are being used by some people as evidence that > > > > certain patients indeed have Lyme. But the NEJM article uses > > > > that Nature paper to undermine that argument. Now you are > > > > reporting that Dr. Fallon has patients that relapse rapidly > off > > > > Rocephin; too rapidly to be accounted for by a rebound in > > > > bacterial population. > > > > > > > > You appear then, by way of Dr. Fallon, to be lending weight to > > the > > > > NEJM's position. > > > > > > > > That's OK. But the next question is: how much credibility > will > > > > Lyme patients lose if they do not address this issue > > proactively? > > > > A good fall-back position is for patients/LLMDs to say that, > in > > > > accordance with the Nature paper and the criticism of Lyme > > > > activism that appears in the NEJM article, Rocephin may > indeed > > > > be palliative by way of glutamate transport, but at least this > > > > demonstrates glutamate toxicity in patients that had been > > > > otherwise shunned by the medical community. That is, those in > > > > the medical establishment who shun sick people can not use > > > > the Nature paper to undermine the LLMDs that these patients > > > > turn to with out simultaneously acknowledging the glutamate > > > > toxicity occuring within the patients they (the conventional > > > > doctors) have abandoned. > > > > > > > > Lyme activists need to use the Nature paper to their own > > > > advantages, and not have it used against them. But that can't > > > > happen until we get clear on the extent to which Rocephin is > > > > palliative vs. curative. > > > > > > > > Matt Quote Link to comment Share on other sites More sharing options...
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