Re: Gut flora (and probiotics?) and reaction to abx

[Guest guest]

Nelly:

Very very good question.

IMO, there are alot of agents that can alter the cells along the

intestinal tract and change permeability and what resides there -

it's probably a very dynamic situation in there!

There are agents that change absorption of certain substances, some

of which are known (like adding oil to CoQ10) and I'm sure alot are

not.

SEE REFERENCE 1

Significance of IgA antibodies and Candida.

SEE Reference 2

I guess because I have horses, and their guts/intestines are so much

more sensitive than ours, I have researched the intestinal mucosal

membrane, and absorption. DFor several years, a PREbiotics (FOS)

have been available to balance intestinal flora in horses (so of

course I had to try it too).

In horses, we prefer to give PREbiotics (FructoOligoSaccharide -FOS

instead of probiotics - the thinking is you feed the gut bugs FOS and

they multiply on their own. There hasn't been a whole lot of studies

on humans with this stuff till recently...

SEE REFERENCE 3 and 4

But in some older (rat) studies... FOS increases intentinal

permeability- and alters the bioavaiability of some drugs - so I

never gave the horses (or me) FOS while on any Meds.

Although here's a new study on HUMANS and the absorption of the micro

elements in the presence of FOS

SEE REFERENCE 5 and 6

REFERENCE 1

Vol. 296, Issue 1, 84-90, January 2001

Modulation of Intestinal Permeability by Nitric Oxide Donors:

Implications in Intestinal Delivery of Poorly Absorbable Drugs

Akira Yamamoto, Hiroyuki Tatsumi, Masato Maruyama, Tomomi Uchiyama,

Naoki Okada and Takuya Fujita

Department of Biopharmaceutics, Kyoto Pharmaceutical University,

Kyoto, Japan

REFERENCE 2

Intestinal colonization with Candida albicans and mucosal immunity

http://www.wjgnet.com/1007-9327/10/2124.pdf

REFERENCE 3

J Agric Food Chem. 2005 Apr 20;53(8):2914-21.

In vitro investigation into the potential prebiotic activity of honey

oligosaccharides.

REFERENCE 4

Fructooligosaccharide supplementation in the yearling horse: effects

on fecal pH, microbial content, and volatile fatty acid

concentrations.

REFERENCE 5

J Am Coll Nutr. 2005 Feb;24(1):30-7.

Influence of short-chain fructo-oligosaccharides (sc-FOS) on

absorption of Cu, Zn, and Se in healthy postmenopausal women.

REFERENCE 6

Dig Liver Dis. 2002 Sep;34 Suppl 2:S111-20.

Nutritional aspects of short-chain fructooligosaccharides: natural

occurrence, chemistry, physiology and health implications.

Bornet FR, Brouns F, Tashiro Y, Duvillier V.

Nutri-Health SA, Rueil-Malmaison, France. frj.bornet@nutri-health-

sa.com

Short-chain fructooligosaccharides occur in a number of edible

plants, such as chicory, onions, asparagus, wheat... They are a group

of linear fructose oligomers with a degree of polymerisation ranging

from n = 1 up to 5 (oligosaccharides). Short-chain

fructooligosaccharides, to a large extent, escape digestion in the

human upper intestine and reach the colon where they are totally

fermented mostly to lactate, short chain fatty acids (acetate,

propionate and butyrate), and gas, like dietary fibres. As a

consequence of their fermentation, their caloric value is

approximately 2 Kcal/g. A faecal bulking effect of

fructooligosaccharides has been observed in humans. An important

property of short-chain fructooligosaccharides is the stimulation of

bifidobacterial growth specifically while suppressing the growth of

potentially harmful species such as, for example, Clostridium

perfringens in the colon. It is associated with a decrease in faecal

pH, an increase in faecal or colonic organic acids, a decrease in the

production of nitrogenous end products in urine and stools, a

decrease in faecal bacterial enzymatic activities and a modification

in faecal neutral sterols. The short-chain fructooligosaccharides

enhance magnesium absorption in humans and have been shown, in animal

models, to reduce colon tumour development by enhancing both colon

butyrate concentrations and local immune system effectors.