Re: marie - ryle

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Dr. Ryll M.D. Hodologica <usenethod@...> wrote:

Interestin'. I want to find out more but I am not finding anything in pubmed or google - any leads?<msmabrry@y...> wrote:> I believe there is a Dr. Ryle in Carmichael, CA who> subscribes to the vasculitis theory. I think he was> one of the first Docs in US to study CFS. > Marie> --- Hodologica <usenethod@y...> wrote:> > > > I feel vasculitis should be another leading suspect.> > This could cause> > poor perfusion in the brain. And, as Cheney> > brainstorms, it could> > self-intensify, if poor perfusion of the heart were> > itself to> > compromise heart function and thence circulation, in> > a vicous cycle.> > > > Microvasculitis impacts perfusion by simply> > deforming/narrowing the>

> capillaries. Endothelial (vessel wall) cells swell> > and reproduce> > abnormally. This has the potential to completely> > stagnate the capillary. > > > > Vasculitis and perivasculitis are the most> > ubiquitous lesions of> > syphilis. Vasculitis has also been found often in> > lyme in many cases.> > (I dont know for sure of any whole tissue histology> > of lyme; if there> > were any I wonder if vasculitis *might* be found to> > in fact feature in> > every case. I get a vague sense that histology of> > needle biopsy> > samples may not be as good as autopsy in some ways,> > but I am> > uncertain. I do not remember whether all the lyme> > histology I know of> > is on needle-biopsy material).> > > > Al, I didnt know Goldstein had shown hypoperfusion> > via SPECT -

thats> > very interesting. Do you know why this finding didnt> > silence the> > psychologizing school of CFS/ME? Do you know of any> > non-needle> > histology on CFS/ME or chronic borreliosis? I have> > looked a bit but> > found little. The only CFS histology I found was> > muscle biopsies where> > myocytes (muscle cells) were primarily examined. One> > would think the> > investigators would have noticed any vasculitis if> > present but who> > knows. Rich, you really know CFS literature so> > perhaps you have some> > insight?> > > > > > > > > > > Hi all,> > > > > > > > The SPECT Brain Scans that were done in

the> > early 90's by Jay > > > Goldstein & others on CFS patients showed > > > > Hypoperfusion (Low Blood Flow).> > > > > > > > As a result of the Peckerman study, Dr. Cheney> > says the result of > > > the low cardiac output in CFS is poor> > micro-circulation . It would > > > appear that this is what caused the> > Hypoperfusion in the SPECT > > > Scans. Right ?> > > > > > > > > > > > Al> > > > __________________________________________________