Penny- Graves disease ?Pathogens and auto-antigens

[Guest guest]

Here's a paper that bolsters the view that a pathogen

is the trigger, but the body goes awry and starts attcking itself.

Personally- I think the pathogens still there- they just can't fins

it.

I have a very hard time beleiving the immune system just goes awry

in 15% of the developed county's insurance covered population..

How much auto-immune disease is there in the 3rd world?

ANy one got the Stats?

_________________________________________________________________

Thyroid. 2004 Nov;14(11):964-6.

Homologies between proteins of Borrelia burgdorferi and thyroid

autoantigens.

Benvenga S, Guarneri F, Vaccaro M, Santarpia L, Trimarchi F.

Sezione di Endocrinologia del Dipartimento Clinico Sperimentale di

Medicina e Farmacologia, Universita di Messina, Messina, Italy.

s.benvenga@...

Subclinical exposure to microbic antigens that share amino acid

sequence homology with self antigens might trigger autoimmune

diseases in genetically predisposed individuals via molecular

mimicry. Genetic predisposition to Graves' disease (GD) or

Hashimoto's thyroiditis (HT) is conferred by HLA loci DR3 or DR5,

respectively. Yersinia enterocolitica (YE) outer proteins (YOPs) are

candidate triggers based on the high prevalence of serum antibodies

(Ab) against YOPs in autoimmune thyroid diseases (AITD) and

reactivity of these Ab with hTSH-R, suggesting homology between YOPs

and hTSH-R. We have reported previously that the spirochete Borrelia

burgdorferi (Bb) could be another trigger. We have explored further

the homology of hTSH-R with YE and Bb. Using the Basic Local

Alignment Search Tool (BLAST), we found four matches with YE and five

matches with Bb . Residues 22-272, 186-330, 319-363 and 684-749 of

hTSH-R matched YopM, Ysp, exopolygalacturonase and SpyA of YE

(identity 23-31%, similarity 40-48%). Residues 112-205, 127-150, 141-

260, 299-383 and 620-697 of hTSH-R matched outer surface protein A,

flagellar motor rotation protein A, two hypothetical proteins (BBG02

and BBJ08) and DNA recombinase/ATP dependent helicase of Borrelia

(identity 27-50%, similarity 40-75%). Interestingly, the above hTSH-R

regions coincide with (or include) known human T-cell epitopes: aa 52-

71, 140-176, 240-270, 340-380 and 441-661. Our data strengthen the

hypothesis of Bb and YE as environmental triggers of AITD in

genetically predisposed persons through molecular mimicry mechanisms.

PMID: 15671776 [PubMed - indexed for MEDLINE]

[Guest guest]

Yeah, can you believe it? There have been several (mostly european)

studies in the last few years linking thyroid disease and bacteria.

A greek study actually suggests treating with abx. Do you think

anyone pays attention? Arrrghhhh!

I've never bought the hashimoto's/graves theory that the body can't

recognize it's own thryoid and starts attacking itself. I've always

thought it was attacking something that we just aren't seeing. The

Greek study found that a huge percentage of people with hashimotos

tested positive for the yersinia bacteria, compared to healthy

controls who tested negative. (related to, but not the same yersinia

strain that caused the bubonic plague).

I sometimes can't believe what gets ignored or laughed off. I

remember asking a couple of doctors for the new yersinia test and

they both laughed saying they didn't think I had the bubonic

plague. :-( So that's why I kept looking, until I found an infection

that wasn't laughed off. Chronic osteomyelitis.

penny

> Here's a paper that bolsters the view that a pathogen

> is the trigger, but the body goes awry and starts attcking itself.

>

> Personally- I think the pathogens still there- they just can't

fins

> it.

> I have a very hard time beleiving the immune system just goes awry

> in 15% of the developed county's insurance covered population..

>

> How much auto-immune disease is there in the 3rd world?

> ANy one got the Stats?

>

> _________________________________________________________________

>

> Thyroid. 2004 Nov;14(11):964-6.

> Homologies between proteins of Borrelia burgdorferi and thyroid

> autoantigens.

>

> Benvenga S, Guarneri F, Vaccaro M, Santarpia L, Trimarchi F.

>

> Sezione di Endocrinologia del Dipartimento Clinico Sperimentale di

> Medicina e Farmacologia, Universita di Messina, Messina, Italy.

> s.benvenga@m...

>

> Subclinical exposure to microbic antigens that share amino acid

> sequence homology with self antigens might trigger autoimmune

> diseases in genetically predisposed individuals via molecular

> mimicry. Genetic predisposition to Graves' disease (GD) or

> Hashimoto's thyroiditis (HT) is conferred by HLA loci DR3 or DR5,

> respectively. Yersinia enterocolitica (YE) outer proteins (YOPs)

are

> candidate triggers based on the high prevalence of serum

antibodies

> (Ab) against YOPs in autoimmune thyroid diseases (AITD) and

> reactivity of these Ab with hTSH-R, suggesting homology between

YOPs

> and hTSH-R. We have reported previously that the spirochete

Borrelia

> burgdorferi (Bb) could be another trigger. We have explored

further

> the homology of hTSH-R with YE and Bb. Using the Basic Local

> Alignment Search Tool (BLAST), we found four matches with YE and

five

> matches with Bb . Residues 22-272, 186-330, 319-363 and 684-749 of

> hTSH-R matched YopM, Ysp, exopolygalacturonase and SpyA of YE

> (identity 23-31%, similarity 40-48%). Residues 112-205, 127-150,

141-

> 260, 299-383 and 620-697 of hTSH-R matched outer surface protein

A,

> flagellar motor rotation protein A, two hypothetical proteins

(BBG02

> and BBJ08) and DNA recombinase/ATP dependent helicase of Borrelia

> (identity 27-50%, similarity 40-75%). Interestingly, the above

hTSH-R

> regions coincide with (or include) known human T-cell epitopes: aa

52-

> 71, 140-176, 240-270, 340-380 and 441-661. Our data strengthen the

> hypothesis of Bb and YE as environmental triggers of AITD in

> genetically predisposed persons through molecular mimicry

mechanisms.

>

> PMID: 15671776 [PubMed - indexed for MEDLINE]

[Guest guest]

I think it doesn't exist- until they introduce the sugar into the

diet.

> Here's a paper that bolsters the view that a pathogen

> is the trigger, but the body goes awry and starts attcking itself.

>

> Personally- I think the pathogens still there- they just can't

fins

> it.

> I have a very hard time beleiving the immune system just goes awry

> in 15% of the developed county's insurance covered population..

>

> How much auto-immune disease is there in the 3rd world?

> ANy one got the Stats?

>

> _________________________________________________________________

>

> Thyroid. 2004 Nov;14(11):964-6.

> Homologies between proteins of Borrelia burgdorferi and thyroid

> autoantigens.

>

> Benvenga S, Guarneri F, Vaccaro M, Santarpia L, Trimarchi F.

>

> Sezione di Endocrinologia del Dipartimento Clinico Sperimentale di

> Medicina e Farmacologia, Universita di Messina, Messina, Italy.

> s.benvenga@m...

>

> Subclinical exposure to microbic antigens that share amino acid

> sequence homology with self antigens might trigger autoimmune

> diseases in genetically predisposed individuals via molecular

> mimicry. Genetic predisposition to Graves' disease (GD) or

> Hashimoto's thyroiditis (HT) is conferred by HLA loci DR3 or DR5,

> respectively. Yersinia enterocolitica (YE) outer proteins (YOPs)

are

> candidate triggers based on the high prevalence of serum

antibodies

> (Ab) against YOPs in autoimmune thyroid diseases (AITD) and

> reactivity of these Ab with hTSH-R, suggesting homology between

YOPs

> and hTSH-R. We have reported previously that the spirochete

Borrelia

> burgdorferi (Bb) could be another trigger. We have explored

further

> the homology of hTSH-R with YE and Bb. Using the Basic Local

> Alignment Search Tool (BLAST), we found four matches with YE and

five

> matches with Bb . Residues 22-272, 186-330, 319-363 and 684-749 of

> hTSH-R matched YopM, Ysp, exopolygalacturonase and SpyA of YE

> (identity 23-31%, similarity 40-48%). Residues 112-205, 127-150,

141-

> 260, 299-383 and 620-697 of hTSH-R matched outer surface protein

A,

> flagellar motor rotation protein A, two hypothetical proteins

(BBG02

> and BBJ08) and DNA recombinase/ATP dependent helicase of Borrelia

> (identity 27-50%, similarity 40-75%). Interestingly, the above

hTSH-R

> regions coincide with (or include) known human T-cell epitopes: aa

52-

> 71, 140-176, 240-270, 340-380 and 441-661. Our data strengthen the

> hypothesis of Bb and YE as environmental triggers of AITD in

> genetically predisposed persons through molecular mimicry

mechanisms.

>

> PMID: 15671776 [PubMed - indexed for MEDLINE]

[Guest guest]

I firmly believe that the vast amounts of diagnosed " autoimmunity "

is actually collateral damage from the immune system dealing with

infecting pathogens. Granted, there are animal models where auto

immunity, hypersensativity, meyloid series disfunction can be

induced through immunization schedules or pathogen introduction. Ms,

type 1 diabetes, even leukemia and polycythemia can be induced in

murine animal models with a viral infection. Just think about the

guinea pig asthma model, pertussus immunization is used to induce

asthma in guinea pigs. Does anyone think that our children fare any

better than guinea pigs with DPT and all the other vaccinations

given on a truncated schedule. All that adjuvant and other

wonderful protein etc. just add to the " mystery " of why 25% of our

children are atopic or asthmatic.

Do any of you think that the medical establishment is interested in

curing autoimmunity. Those poor rheumatologists don't perform many

expensive proceedures so their incomes are dependent on keeping

their waiting rooms full. Do you think that it's good for the

profession to start curing their patients of the underlying

infections that contribute to the " autoimmune " disease state. That's

heresy to even discuss the possibility. The next time there's an MS

Walk for a Cure fund raising walk or meeting, try to talk to the

sponsors about Borrelia burgdorferi infection as a possible

trigger. It's a threat to their franchise and you'll be

marginalized at best.

Using a frequency generator, I recently hit the nexus of my

CFIDS/FM/CWD Lyme pretty hard and paid the price. The herxheimer

started after 24 hours and was pretty intense for the next 3 days.

My brain stem and neck were screaming with pain and I couldn't move

my head. My thyroid hurt like a large swollen gland and I lost the

ability to swallow which was pretty scary because the experience was

ALS symptom like. All said and done, everything is much better, I

lost weight and everything feels better. I'm in the precess of

repeating my sessions with the frequency generator to isolate the

exact frequencies that caused that herx. This whole thing really is

a drag.

> Here's a paper that bolsters the view that a pathogen

> is the trigger, but the body goes awry and starts attcking itself.

>

> Personally- I think the pathogens still there- they just can't

fins

> it.

> I have a very hard time beleiving the immune system just goes awry

> in 15% of the developed county's insurance covered population..

>

> How much auto-immune disease is there in the 3rd world?

> ANy one got the Stats?

>

> _________________________________________________________________

>

> Thyroid. 2004 Nov;14(11):964-6.

> Homologies between proteins of Borrelia burgdorferi and thyroid

> autoantigens.

>

> Benvenga S, Guarneri F, Vaccaro M, Santarpia L, Trimarchi F.

>

> Sezione di Endocrinologia del Dipartimento Clinico Sperimentale di

> Medicina e Farmacologia, Universita di Messina, Messina, Italy.

> s.benvenga@m...

>

> Subclinical exposure to microbic antigens that share amino acid

> sequence homology with self antigens might trigger autoimmune

> diseases in genetically predisposed individuals via molecular

> mimicry. Genetic predisposition to Graves' disease (GD) or

> Hashimoto's thyroiditis (HT) is conferred by HLA loci DR3 or DR5,

> respectively. Yersinia enterocolitica (YE) outer proteins (YOPs)

are

> candidate triggers based on the high prevalence of serum

antibodies

> (Ab) against YOPs in autoimmune thyroid diseases (AITD) and

> reactivity of these Ab with hTSH-R, suggesting homology between

YOPs

> and hTSH-R. We have reported previously that the spirochete

Borrelia

> burgdorferi (Bb) could be another trigger. We have explored

further

> the homology of hTSH-R with YE and Bb. Using the Basic Local

> Alignment Search Tool (BLAST), we found four matches with YE and

five

> matches with Bb . Residues 22-272, 186-330, 319-363 and 684-749 of

> hTSH-R matched YopM, Ysp, exopolygalacturonase and SpyA of YE

> (identity 23-31%, similarity 40-48%). Residues 112-205, 127-150,

141-

> 260, 299-383 and 620-697 of hTSH-R matched outer surface protein

A,

> flagellar motor rotation protein A, two hypothetical proteins

(BBG02

> and BBJ08) and DNA recombinase/ATP dependent helicase of Borrelia

> (identity 27-50%, similarity 40-75%). Interestingly, the above

hTSH-R

> regions coincide with (or include) known human T-cell epitopes: aa

52-

> 71, 140-176, 240-270, 340-380 and 441-661. Our data strengthen the

> hypothesis of Bb and YE as environmental triggers of AITD in

> genetically predisposed persons through molecular mimicry

mechanisms.

>

> PMID: 15671776 [PubMed - indexed for MEDLINE]

[Guest guest]

Hi, which frequencies have you been trying? I've got a Beam-ray, but

don't use it much because I don't have the patience to try to figure

out which frequencies to try, and I also worry a bit about the

guinea pig factor. I could kill one bug (or stir it up) allowing

another, even worse one to flourish.

Tony tested one on some organisms and found that the handles of the

model he tested were covered with staph, alive and thriving, which

wasn't encouraging either. You've got to find the right frequencies.

It seems like everyone who's done well with the frequency generators

are kind of tech geeks. Mostly guys who are into all that electrical

engineering kind of stuff. I wish it were simpler for me to use,

because I do believe there's tremendous potential using frequencies

to kill bugs. I know it works for yeast/fungus as I have a

distinctive smell when yeast dies, and that happens when I use the

Beam Ray, same as it does with anti-fungals.

penny

> > Here's a paper that bolsters the view that a pathogen

> > is the trigger, but the body goes awry and starts attcking

itself.

> >

> > Personally- I think the pathogens still there- they just can't

> fins

> > it.

> > I have a very hard time beleiving the immune system just goes

awry

> > in 15% of the developed county's insurance covered population..

> >

> > How much auto-immune disease is there in the 3rd world?

> > ANy one got the Stats?

> >

> > _________________________________________________________________

> >

> > Thyroid. 2004 Nov;14(11):964-6.

> > Homologies between proteins of Borrelia burgdorferi and thyroid

> > autoantigens.

> >

> > Benvenga S, Guarneri F, Vaccaro M, Santarpia L, Trimarchi F.

> >

> > Sezione di Endocrinologia del Dipartimento Clinico Sperimentale

di

> > Medicina e Farmacologia, Universita di Messina, Messina, Italy.

> > s.benvenga@m...

> >

> > Subclinical exposure to microbic antigens that share amino acid

> > sequence homology with self antigens might trigger autoimmune

> > diseases in genetically predisposed individuals via molecular

> > mimicry. Genetic predisposition to Graves' disease (GD) or

> > Hashimoto's thyroiditis (HT) is conferred by HLA loci DR3 or

DR5,

> > respectively. Yersinia enterocolitica (YE) outer proteins (YOPs)

> are

> > candidate triggers based on the high prevalence of serum

> antibodies

> > (Ab) against YOPs in autoimmune thyroid diseases (AITD) and

> > reactivity of these Ab with hTSH-R, suggesting homology between

> YOPs

> > and hTSH-R. We have reported previously that the spirochete

> Borrelia

> > burgdorferi (Bb) could be another trigger. We have explored

> further

> > the homology of hTSH-R with YE and Bb. Using the Basic Local

> > Alignment Search Tool (BLAST), we found four matches with YE and

> five

> > matches with Bb . Residues 22-272, 186-330, 319-363 and 684-749

of

> > hTSH-R matched YopM, Ysp, exopolygalacturonase and SpyA of YE

> > (identity 23-31%, similarity 40-48%). Residues 112-205, 127-150,

> 141-

> > 260, 299-383 and 620-697 of hTSH-R matched outer surface protein

> A,

> > flagellar motor rotation protein A, two hypothetical proteins

> (BBG02

> > and BBJ08) and DNA recombinase/ATP dependent helicase of

Borrelia

> > (identity 27-50%, similarity 40-75%). Interestingly, the above

> hTSH-R

> > regions coincide with (or include) known human T-cell epitopes:

aa

> 52-

> > 71, 140-176, 240-270, 340-380 and 441-661. Our data strengthen

the

> > hypothesis of Bb and YE as environmental triggers of AITD in

> > genetically predisposed persons through molecular mimicry

> mechanisms.

> >

> > PMID: 15671776 [PubMed - indexed for MEDLINE]

[Guest guest]

I've gotten results between 188,000Hz and 198,000Hz specifically at

192,500Hz which I'm trying again, but probably need to go for a

longer duration. The other range is from 375,000Hz to 385,000Hz.

Your Beam Ray probably doesn't operate above 10,000Hz. Go to the

CAFL for some frequencies appropriate for that device.

With a contact device you really need to complete the circut to have

any effect. So, it doesn't surprise that someone was able to culture

staph off the hand holds. This is same reason that birds can sit on

high tension wires and not get fried.

As far as stirring the bugs up, I don't think that is that big of an

issue. The real issue would be pleomorphism, the tratment

frequencies will change with time so you have to be able to sweep

ranges of frequencies. Many different pathogens like to

compartmentalize themselves in specific areas of your body. I think

that ultimately, you end up reducing your immunological load by

getting rid of anything that doesn't belong which will help you to

better fight off what's left. For someone who's chronically sick,

getting rid of systemic candada is huge.

Tom B.

> > > Here's a paper that bolsters the view that a pathogen

> > > is the trigger, but the body goes awry and starts attcking

> itself.

> > >

> > > Personally- I think the pathogens still there- they just can't

> > fins

> > > it.

> > > I have a very hard time beleiving the immune system just goes

> awry

> > > in 15% of the developed county's insurance covered

population..

> > >

> > > How much auto-immune disease is there in the 3rd world?

> > > ANy one got the Stats?

> > >

> > >

_________________________________________________________________

> > >

> > > Thyroid. 2004 Nov;14(11):964-6.

> > > Homologies between proteins of Borrelia burgdorferi and

thyroid

> > > autoantigens.

> > >

> > > Benvenga S, Guarneri F, Vaccaro M, Santarpia L, Trimarchi F.

> > >

> > > Sezione di Endocrinologia del Dipartimento Clinico

Sperimentale

> di

> > > Medicina e Farmacologia, Universita di Messina, Messina,

Italy.

> > > s.benvenga@m...

> > >

> > > Subclinical exposure to microbic antigens that share amino

acid

> > > sequence homology with self antigens might trigger autoimmune

> > > diseases in genetically predisposed individuals via molecular

> > > mimicry. Genetic predisposition to Graves' disease (GD) or

> > > Hashimoto's thyroiditis (HT) is conferred by HLA loci DR3 or

> DR5,

> > > respectively. Yersinia enterocolitica (YE) outer proteins

(YOPs)

> > are

> > > candidate triggers based on the high prevalence of serum

> > antibodies

> > > (Ab) against YOPs in autoimmune thyroid diseases (AITD) and

> > > reactivity of these Ab with hTSH-R, suggesting homology

between

> > YOPs

> > > and hTSH-R. We have reported previously that the spirochete

> > Borrelia

> > > burgdorferi (Bb) could be another trigger. We have explored

> > further

> > > the homology of hTSH-R with YE and Bb. Using the Basic Local

> > > Alignment Search Tool (BLAST), we found four matches with YE

and

> > five

> > > matches with Bb . Residues 22-272, 186-330, 319-363 and 684-

749

> of

> > > hTSH-R matched YopM, Ysp, exopolygalacturonase and SpyA of YE

> > > (identity 23-31%, similarity 40-48%). Residues 112-205, 127-

150,

> > 141-

> > > 260, 299-383 and 620-697 of hTSH-R matched outer surface

protein

> > A,

> > > flagellar motor rotation protein A, two hypothetical proteins

> > (BBG02

> > > and BBJ08) and DNA recombinase/ATP dependent helicase of

> Borrelia

> > > (identity 27-50%, similarity 40-75%). Interestingly, the above

> > hTSH-R

> > > regions coincide with (or include) known human T-cell

epitopes:

> aa

> > 52-

> > > 71, 140-176, 240-270, 340-380 and 441-661. Our data strengthen

> the

> > > hypothesis of Bb and YE as environmental triggers of AITD in

> > > genetically predisposed persons through molecular mimicry

> > mechanisms.

> > >

> > > PMID: 15671776 [PubMed - indexed for MEDLINE]