Guest guest Posted September 8, 2001 Report Share Posted September 8, 2001 Dear Jen, Thanks for the info. My grandmother was diagnosed with RA around age 30 on my Dad's side. My mom was diagnosed with Fibromyalgia about age 45 although she has probably had it for a lot longer. So I definitely believe their is a genetic predisposition. jatw@... Re: heredity and still's > tatjana wilson " <tatjanawilson@... wrote: > " i am also interested in finding out, if > this disease is hereditary. does anyone know? my > doctors aren't sure at all. " > > Well there aren't any definite answers yet but this is the current therory > that Still's is an autoimmune disease and that certain families have genetic > makeup that predisposes them to develop an autoimmune disease, so yes you > could look at it as the chance of developing stills, lupus, diabetes type 1, > chron's or any of the other hundreds of autoimmune diseases is heredity. > They feel that genetic mutations play a big part, and the other part of the > theory is that once you have this genetic predisposition to develop a > disease you later come into contact with a certain " trigger " that activates > the disease. There is no one known trigger though researches believe > viruses and or vaccines play a huge role, also stress. The trigger theory > would explain why only certain members of a family develop a disease, while > others do not. There is a huge study now between twins with RA and lupus, > this study will help shed light on this theory. > > You may not realize that you have family members with a completly different > illness than you but they both came from the same defective gene that was > passed down. I have a cousin with juvenile diabetes, 2 with RA and one > with lupus, my great grandmother and I had a great uncle to die at 34 with > severe RA and high fevers, we feel now that he probably had still's but of > course was never diagnosed (he died back in the 1930's) anyway all are on my > mother's side and her mother's and they are probably all from the same > defective gene. Also have cousins who had recurrent miscarriages, several > aunts and great grandmother with recurrent miscarriages, died at from > premature stroke, almost all brothers and sisters have died from stroke, > leading to the passing down of the anticardiolipin antibodies that I have. > > It's always a good idea to thouroughly research you family's medical > backgroud, even the smallest detail that you think wouldn't matter like > miscarriages may be a vital clue. > > Jenn > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 11, 2001 Report Share Posted September 11, 2001 hi jennifer, thank you so much for the information. it was very very informative and more then i have been able to research so far. i have an apt in the university clinic in heidelberg next week for a genetic counseling and it will be very interesting to see what they have to say about it. when i called to make the apt, they were confused and i had to fax them my doctors note so they can do some research prior to my apt. i will keep you updated on the outcome and thank you in the meantime for the info. and good luck to you with your health and with trying for a baby. tatjana --- Jay wrote: > tatjana wilson " <tatjanawilson@... wrote: > " i am also interested in finding out, if > this disease is hereditary. does anyone know? my > doctors aren't sure at all. " > > Well there aren't any definite answers yet but this > is the current therory > that Still's is an autoimmune disease and that > certain families have genetic > makeup that predisposes them to develop an > autoimmune disease, so yes you > could look at it as the chance of developing stills, > lupus, diabetes type 1, > chron's or any of the other hundreds of autoimmune > diseases is heredity. > They feel that genetic mutations play a big part, > and the other part of the > theory is that once you have this genetic > predisposition to develop a > disease you later come into contact with a certain > " trigger " that activates > the disease. There is no one known trigger though > researches believe > viruses and or vaccines play a huge role, also > stress. The trigger theory > would explain why only certain members of a family > develop a disease, while > others do not. There is a huge study now between > twins with RA and lupus, > this study will help shed light on this theory. > > You may not realize that you have family members > with a completly different > illness than you but they both came from the same > defective gene that was > passed down. I have a cousin with juvenile > diabetes, 2 with RA and one > with lupus, my great grandmother and I had a great > uncle to die at 34 with > severe RA and high fevers, we feel now that he > probably had still's but of > course was never diagnosed (he died back in the > 1930's) anyway all are on my > mother's side and her mother's and they are probably > all from the same > defective gene. Also have cousins who had > recurrent miscarriages, several > aunts and great grandmother with recurrent > miscarriages, died at from > premature stroke, almost all brothers and sisters > have died from stroke, > leading to the passing down of the anticardiolipin > antibodies that I have. > > It's always a good idea to thouroughly research you > family's medical > backgroud, even the smallest detail that you think > wouldn't matter like > miscarriages may be a vital clue. > > Jenn > > > __________________________________________________ Quote Link to comment Share on other sites More sharing options...
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