Bb isolated from dogs after 30 days high-dose abx

[Guest guest]

But of course the poor pups didn't get Tony's patented form of

Cognitive Behavioral Therapy, [wherein mammals complaining of

Borrelia-induced illness are called " Stupid! Stupid! Stupid! " and

told to treat their pseudomonads, instead].

Apparently, there are many as yet undocumented cases of spirochetes

being eradicated by this technique.

Tony can certainly bark, I'm guessing he's fluent in dog and there's

hope for the poor pooches yet.

In case I'm wrong, I am arranging for a scholarship to send Tony to

the Doolittle School for Animal Communications, where he will learn

to translate " Stupid! " into the native syntax of each mammalian

species.

No longer will the doctor from Down Under be kept awake at night,

tormented by creatures who are only a few stiff insults away from

having their health restored.

Yours truly,

- Stupid! - Scha

> This is a paper I hadnt seen. Leave it to the vets of Cornell to

point

> out reality to the MDs... good thing weve got a crack team of

BSers to

> deftly brush it under the rug.

>

> The doxy-group dogs took 20 mg/kg/d, which is like me sucking down

> 1200 mg of doxy per day (however, dogs may excrete it faster or

> something... I dont know... but the investigators did measure the

> plasma drug levels, by bioassay, to make sure they were

sufficient).

>

> One of six doxy-treated dogs, kept in isolation, developed

symptomatic

> arthritis despite the 30-day treatment! And remained culture+ and

PCR+.

>

> This pisses me right off!

>

> ==============================

>

> J Clin Microbiol. 1997 Jan;35(1):111-6.

>

> Persistence of Borrelia burgdorferi in experimentally infected

> dogs after antibiotic treatment.

>

> Straubinger RK, Summers BA, Chang YF, Appel MJ.

>

> A. Baker Institute for Animal Health, College of

Veterinary

> Medicine, Cornell University, Ithaca, New York 14853, USA.

> rks4@c...

>

> In specific-pathogen-free dogs experimentally infected with

> Borrelia burgdorferi by tick exposure, treatment with high doses of

> amoxicillin or doxycycline for 30 days diminished but failed to

> eliminate persistent infection. Although joint disease was

prevented

> or cured in five of five amoxicillin- and five of six

> doxycycline-treated dogs, skin punch biopsies and multiple tissues

> from necropsy samples remained PCR positive and B. burgdorferi was

> isolated from one amoxicillin- and two doxycycline-treated dogs

> following antibiotic treatment. In contrast, B. burgdorferi was

> isolated from six of six untreated infected control dogs and joint

> lesions were found in four of these six dogs. Serum antibody

levels to

> B. burgdorferi in all dogs declined after antibiotic treatment.

> Negative antibody levels were reached in four of six doxycycline-

and

> four of six amoxicillin-treated dogs. However, in dogs that were

kept

> in isolation for 6 months after antibiotic treatment was

discontinued,

> antibody levels began to rise again, presumably in response to

> proliferation of the surviving pool of spirochetes. Antibody

levels in

> untreated infected control dogs remained high.

>

> PMID: 8968890

[Guest guest]

Tony wrote in part:

"People that know me know that I don't make too many errors."

Perpetuating an ignorant prejudice regarding Lyme disease is a very large error, in my book. Knowing you would not change my view of the matter, because my view has nothing to do with you, personally.

Your impulse to turn every illness into sinus infection by run of the mill bacteria is no more respectable to me, intellectually, than an effort to turn everything into a variant of Sarcoidosis. Both efforts rest on a stunning disregard for data, evidence and the rules of logic. Both are equally offensive to my regard for those things.

But hate? Come on, Tony! I spent hours in the ER yesterday, while doctors pumped my veins with valium to stop my legs from snapping themselves in two, they were shaking so hard. Do you really think I spent those hours thinking about you? Are you that self-centered?

I don't hate you, Tony. I just don't agree with you. I don't object to all your posts, I object to specific posts for specific reasons and the name of the author is not one of them.

If you're half the scientist you say you are, you should have no trouble grasping that distinction. Do you?

dumbaussie2000 <dumbaussie2000@...> wrote:

People that know me know that I don't make too many errors.I was laughed off many forums and arguements would erupt when I would say your stomach and lower intestinal complaints are equivalent to PELVIC INFLAMMATORY DISEASE. This 3 years ago would leave everyone stunned, is this aussie crazy or something..Well today it doesn't look so crazy saying you have an inflammatory problem in your gut.I also studied 100 plus samples from patients, I live in australia and after 17 years of studying the bacterial samples from thousands of sufferers, from sinus, stool and throat you shouldn't point a finger at someone with his hand on the pulse of chronic diseases.Newcastle university has done the closest thing to correct procedure by testing people's samples and asking hundreds of symptom questions.When you have an 800,000

dollar a year fiscal statement- this over 17 years equates to many thousands tested. Looking for TOXINS when you have a neurological problem is smarter than trying to point the finger of blame on a spirochete.Your symptoms IMO opinion stem from an erosion of your sinus cavity leaving bacteria to run wild on your brain and nervous system. So when you next go see your lyme literate doc and she is gracious enough to put a finger on your problem go and get your head scanned correctly by a few smarter radiographers that I'm sure penny can put you onto and stop frying your brain.You could also have a pet hate of this aussie and his disbelief that comes from studying bacterial samples, but we have just as many ill per head of population and there's no ticks or lyme bacteria to discover, yet the ill still roll in.I also use my phone finger to contact all corners of the globe. I don't sit here practising my writing skills or

correcting typo's, this is the only way to acquire information. When you have a bacterial problem and you hunt out and make friends with your cities leading microbiologist, working in our largest pathology lab, you ain't such a dud.You see most of life's ills come from bacteria that's already there. Oh! you would look differently at things if you discovered the bacteria frying your brain are producing toxic shock syndrome toxins.tony> > This is a paper I hadnt seen. Leave it to the vets of Cornell to > point> > out reality to the MDs... good thing weve got a crack team of > BSers

to> > deftly brush it under the rug.> > > > The doxy-group dogs took 20 mg/kg/d, which is like me sucking down> > 1200 mg of doxy per day (however, dogs may excrete it faster or> > something... I dont know... but the investigators did measure the> > plasma drug levels, by bioassay, to make sure they were > sufficient). > > > > One of six doxy-treated dogs, kept in isolation, developed > symptomatic> > arthritis despite the 30-day treatment! And remained culture+ and > PCR+.> > > > This pisses me right off! > > > > ==============================> > > > J Clin Microbiol. 1997 Jan;35(1):111-6.> > > > Persistence of Borrelia burgdorferi in experimentally infected> > dogs after antibiotic treatment.> > >

> Straubinger RK, Summers BA, Chang YF, Appel MJ.> > > > A. Baker Institute for Animal Health, College of > Veterinary> > Medicine, Cornell University, Ithaca, New York 14853, USA.> > rks4@c...> > > > In specific-pathogen-free dogs experimentally infected with> > Borrelia burgdorferi by tick exposure, treatment with high doses of> > amoxicillin or doxycycline for 30 days diminished but failed to> > eliminate persistent infection. Although joint disease was > prevented> > or cured in five of five amoxicillin- and five of six> > doxycycline-treated dogs, skin punch biopsies and multiple tissues> > from necropsy samples remained PCR positive and B. burgdorferi was> > isolated from one amoxicillin- and two doxycycline-treated dogs> > following

antibiotic treatment. In contrast, B. burgdorferi was> > isolated from six of six untreated infected control dogs and joint> > lesions were found in four of these six dogs. Serum antibody > levels to> > B. burgdorferi in all dogs declined after antibiotic treatment.> > Negative antibody levels were reached in four of six doxycycline-> and> > four of six amoxicillin-treated dogs. However, in dogs that were > kept> > in isolation for 6 months after antibiotic treatment was > discontinued,> > antibody levels began to rise again, presumably in response to> > proliferation of the surviving pool of spirochetes. Antibody > levels in> > untreated infected control dogs remained high.> > > > PMID: 8968890

[Guest guest]

Good luck! I am actually starting to get annoyed by you and this

doesn't happen often.I go the extra mile to get the facts and

truths. I actually said once to one disbelieving doctor while

standing in his doorway, I'll get to the bottom of this without your

help and fortunately in my case I have.Good luck with your toxic

shock episodes.

cheers and please don't reply tony.

> > > This is a paper I hadnt seen. Leave it to the vets of Cornell

to

> > point

> > > out reality to the MDs... good thing weve got a crack team of

> > BSers to

> > > deftly brush it under the rug.

> > >

> > > The doxy-group dogs took 20 mg/kg/d, which is like me sucking

> down

> > > 1200 mg of doxy per day (however, dogs may excrete it faster or

> > > something... I dont know... but the investigators did measure

the

> > > plasma drug levels, by bioassay, to make sure they were

> > sufficient).

> > >

> > > One of six doxy-treated dogs, kept in isolation, developed

> > symptomatic

> > > arthritis despite the 30-day treatment! And remained culture+

> and

> > PCR+.

> > >

> > > This pisses me right off!

> > >

> > > ==============================

> > >

> > > J Clin Microbiol. 1997 Jan;35(1):111-6.

> > >

> > > Persistence of Borrelia burgdorferi in experimentally

> infected

> > > dogs after antibiotic treatment.

> > >

> > > Straubinger RK, Summers BA, Chang YF, Appel MJ.

> > >

> > > A. Baker Institute for Animal Health, College of

> > Veterinary

> > > Medicine, Cornell University, Ithaca, New York 14853, USA.

> > > rks4@c...

> > >

> > > In specific-pathogen-free dogs experimentally infected with

> > > Borrelia burgdorferi by tick exposure, treatment with high

doses

> of

> > > amoxicillin or doxycycline for 30 days diminished but failed to

> > > eliminate persistent infection. Although joint disease was

> > prevented

> > > or cured in five of five amoxicillin- and five of six

> > > doxycycline-treated dogs, skin punch biopsies and multiple

> tissues

> > > from necropsy samples remained PCR positive and B. burgdorferi

> was

> > > isolated from one amoxicillin- and two doxycycline-treated dogs

> > > following antibiotic treatment. In contrast, B. burgdorferi was

> > > isolated from six of six untreated infected control dogs and

> joint

> > > lesions were found in four of these six dogs. Serum antibody

> > levels to

> > > B. burgdorferi in all dogs declined after antibiotic treatment.

> > > Negative antibody levels were reached in four of six

doxycycline-

>

> > and

> > > four of six amoxicillin-treated dogs. However, in dogs that

were

> > kept

> > > in isolation for 6 months after antibiotic treatment was

> > discontinued,

> > > antibody levels began to rise again, presumably in response to

> > > proliferation of the surviving pool of spirochetes. Antibody

> > levels in

> > > untreated infected control dogs remained high.

> > >

> > > PMID: 8968890

>

>

>

>

> ---------------------------------

>

[Guest guest]

Tony wrote: " ...but we have just as many ill

per head of population and there's no ticks or lyme bacteria to

discover, yet the ill still roll in. "

SO? That doesn't negate the fact the others not living in your part

of the world aren't suffering from Lyme.

Sheesh. With all due respect, that's just common sense.

d.

> > > This is a paper I hadnt seen. Leave it to the vets of Cornell

to

> > point

> > > out reality to the MDs... good thing weve got a crack team of

> > BSers to

> > > deftly brush it under the rug.

> > >

> > > The doxy-group dogs took 20 mg/kg/d, which is like me

sucking

> down

> > > 1200 mg of doxy per day (however, dogs may excrete it

faster or

> > > something... I dont know... but the investigators did

measure the

> > > plasma drug levels, by bioassay, to make sure they were

> > sufficient).

> > >

> > > One of six doxy-treated dogs, kept in isolation, developed

> > symptomatic

> > > arthritis despite the 30-day treatment! And remained

culture+

> and

> > PCR+.

> > >

> > > This pisses me right off!

> > >

> > > ==============================

> > >

> > > J Clin Microbiol. 1997 Jan;35(1):111-6.

> > >

> > > Persistence of Borrelia burgdorferi in experimentally

> infected

> > > dogs after antibiotic treatment.

> > >

> > > Straubinger RK, Summers BA, Chang YF, Appel MJ.

> > >

> > > A. Baker Institute for Animal Health, College of

> > Veterinary

> > > Medicine, Cornell University, Ithaca, New York 14853, USA.

> > > rks4@c...

> > >

> > > In specific-pathogen-free dogs experimentally infected

with

> > > Borrelia burgdorferi by tick exposure, treatment with high

doses

> of

> > > amoxicillin or doxycycline for 30 days diminished but failed

to

> > > eliminate persistent infection. Although joint disease was

> > prevented

> > > or cured in five of five amoxicillin- and five of six

> > > doxycycline-treated dogs, skin punch biopsies and multiple

> tissues

> > > from necropsy samples remained PCR positive and B.

burgdorferi

> was

> > > isolated from one amoxicillin- and two doxycycline-treated

dogs

> > > following antibiotic treatment. In contrast, B. burgdorferi

was

> > > isolated from six of six untreated infected control dogs and

> joint

> > > lesions were found in four of these six dogs. Serum

antibody

> > levels to

> > > B. burgdorferi in all dogs declined after antibiotic treatment.

> > > Negative antibody levels were reached in four of six

doxycycline-

>

> > and

> > > four of six amoxicillin-treated dogs. However, in dogs that

were

> > kept

> > > in isolation for 6 months after antibiotic treatment was

> > discontinued,

> > > antibody levels began to rise again, presumably in

response to

> > > proliferation of the surviving pool of spirochetes. Antibody

> > levels in

> > > untreated infected control dogs remained high.

> > >

> > > PMID: 8968890

>

>

>

>

> ---------------------------------

>

[Guest guest]

It doesn't surprise you? It surprises the heck out of me. Wanna play

who was sicker, don't bother, I'll win, hands down. Most of us don't

look sick (that's half our problem), I looked like an anorexic on

chemo. I have been sick for over 24 years, with remission only

coming in the last 2. My symtoms list was as long as you are tall.

> > > > > This is a paper I hadnt seen. Leave it to the vets of

> Cornell

> > to

> > > > point

> > > > > out reality to the MDs... good thing weve got a crack team

> of

> > > > BSers to

> > > > > deftly brush it under the rug.

> > > > >

> > > > > The doxy-group dogs took 20 mg/kg/d, which is like me

> sucking

> > > down

> > > > > 1200 mg of doxy per day (however, dogs may excrete it

faster

> or

> > > > > something... I dont know... but the investigators did

> measure

> > the

> > > > > plasma drug levels, by bioassay, to make sure they were

> > > > sufficient).

> > > > >

> > > > > One of six doxy-treated dogs, kept in isolation, developed

> > > > symptomatic

> > > > > arthritis despite the 30-day treatment! And remained

> culture+

> > > and

> > > > PCR+.

> > > > >

> > > > > This pisses me right off!

> > > > >

> > > > > ==============================

> > > > >

> > > > > J Clin Microbiol. 1997 Jan;35(1):111-6.

> > > > >

> > > > > Persistence of Borrelia burgdorferi in experimentally

> > > infected

> > > > > dogs after antibiotic treatment.

> > > > >

> > > > > Straubinger RK, Summers BA, Chang YF, Appel MJ.

> > > > >

> > > > > A. Baker Institute for Animal Health, College of

> > > > Veterinary

> > > > > Medicine, Cornell University, Ithaca, New York 14853, USA.

> > > > > rks4@c...

> > > > >

> > > > > In specific-pathogen-free dogs experimentally infected

> with

> > > > > Borrelia burgdorferi by tick exposure, treatment with high

> > doses

> > > of

> > > > > amoxicillin or doxycycline for 30 days diminished but

failed

> to

> > > > > eliminate persistent infection. Although joint disease was

> > > > prevented

> > > > > or cured in five of five amoxicillin- and five of six

> > > > > doxycycline-treated dogs, skin punch biopsies and multiple

> > > tissues

> > > > > from necropsy samples remained PCR positive and B.

> burgdorferi

> > > was

> > > > > isolated from one amoxicillin- and two doxycycline-treated

> dogs

> > > > > following antibiotic treatment. In contrast, B.

burgdorferi

> was

> > > > > isolated from six of six untreated infected control dogs

and

> > > joint

> > > > > lesions were found in four of these six dogs. Serum

antibody

> > > > levels to

> > > > > B. burgdorferi in all dogs declined after antibiotic

> treatment.

> > > > > Negative antibody levels were reached in four of six

> > doxycycline-

> > >

> > > > and

> > > > > four of six amoxicillin-treated dogs. However, in dogs

that

> > were

> > > > kept

> > > > > in isolation for 6 months after antibiotic treatment was

> > > > discontinued,

> > > > > antibody levels began to rise again, presumably in

response

> to

> > > > > proliferation of the surviving pool of spirochetes.

Antibody

> > > > levels in

> > > > > untreated infected control dogs remained high.

> > > > >

> > > > > PMID: 8968890

[Guest guest]

Hi Jelly,

I would like to send you a private message. Would you mind writing to me, retractap at bellsouth dot net, and letting me know your email address?

Sincerely,

[infections] Re: Bb isolated from dogs after 30 days high-dose abx

It doesn't surprise you? It surprises the heck out of me. Wanna play who was sicker, don't bother, I'll win, hands down. Most of us don't look sick (that's half our problem), I looked like an anorexic on chemo. I have been sick for over 24 years, with remission only coming in the last 2. My symtoms list was as long as you are tall.> > > > > This is a paper I hadnt seen. Leave it to the vets of > Cornell > > to > > > > point> > > > > out reality to the MDs... good thing weve got a crack team > of > > > > BSers to> > > > > deftly brush it under the rug.> > > > > > > > > > The doxy-group dogs took 20 mg/kg/d, which is like me > sucking > > > down> > > > > 1200 mg of doxy per day (however, dogs may excrete it faster > or> > > > > something... I dont know... but the investigators did > measure > > the> > > > > plasma drug levels, by bioassay, to make sure they were > > > > sufficient). > > > > > > > > > > One of six doxy-treated dogs, kept in isolation, developed > > > > symptomatic> > > > > arthritis despite the 30-day treatment! And remained > culture+ > > > and > > > > PCR+.> > > > > > > > > > This pisses me right off! > > > > > > > > > > ==============================> > > > > > > > > > J Clin Microbiol. 1997 Jan;35(1):111-6.> > > > > > > > > > Persistence of Borrelia burgdorferi in experimentally > > > infected> > > > > dogs after antibiotic treatment.> > > > > > > > > > Straubinger RK, Summers BA, Chang YF, Appel MJ.> > > > > > > > > > A. Baker Institute for Animal Health, College of > > > > Veterinary> > > > > Medicine, Cornell University, Ithaca, New York 14853, USA.> > > > > rks4@c...> > > > > > > > > > In specific-pathogen-free dogs experimentally infected > with> > > > > Borrelia burgdorferi by tick exposure, treatment with high > > doses > > > of> > > > > amoxicillin or doxycycline for 30 days diminished but failed > to> > > > > eliminate persistent infection. Although joint disease was > > > > prevented> > > > > or cured in five of five amoxicillin- and five of six> > > > > doxycycline-treated dogs, skin punch biopsies and multiple > > > tissues> > > > > from necropsy samples remained PCR positive and B. > burgdorferi > > > was> > > > > isolated from one amoxicillin- and two doxycycline-treated > dogs> > > > > following antibiotic treatment. In contrast, B. burgdorferi > was> > > > > isolated from six of six untreated infected control dogs and > > > joint> > > > > lesions were found in four of these six dogs. Serum antibody > > > > levels to> > > > > B. burgdorferi in all dogs declined after antibiotic > treatment.> > > > > Negative antibody levels were reached in four of six > > doxycycline-> > > > > > > and> > > > > four of six amoxicillin-treated dogs. However, in dogs that > > were > > > > kept> > > > > in isolation for 6 months after antibiotic treatment was > > > > discontinued,> > > > > antibody levels began to rise again, presumably in response > to> > > > > proliferation of the surviving pool of spirochetes. Antibody > > > > levels in> > > > > untreated infected control dogs remained high.> > > > > > > > > > PMID: 8968890

[Guest guest]

Jelly

I never get into playing who was sicker? I think I posted over 3000

times and one thing I never got into was that type of niggling. I

feel infrastructure of your anatomy matters as to your chances of a

quicker remission.It's like repairing an old classic car if the

chassis is very rusted the project doesn't become easy. you

virtually got to battle from the position on the ladder you come

from and work your way to the top.I feel this determines how serious

your therapy and goals should be focused.

tony

> > > > > > This is a paper I hadnt seen. Leave it to the vets of

> > Cornell

> > > to

> > > > > point

> > > > > > out reality to the MDs... good thing weve got a crack

team

> > of

> > > > > BSers to

> > > > > > deftly brush it under the rug.

> > > > > >

> > > > > > The doxy-group dogs took 20 mg/kg/d, which is like me

> > sucking

> > > > down

> > > > > > 1200 mg of doxy per day (however, dogs may excrete it

> faster

> > or

> > > > > > something... I dont know... but the investigators did

> > measure

> > > the

> > > > > > plasma drug levels, by bioassay, to make sure they were

> > > > > sufficient).

> > > > > >

> > > > > > One of six doxy-treated dogs, kept in isolation,

developed

> > > > > symptomatic

> > > > > > arthritis despite the 30-day treatment! And remained

> > culture+

> > > > and

> > > > > PCR+.

> > > > > >

> > > > > > This pisses me right off!

> > > > > >

> > > > > > ==============================

> > > > > >

> > > > > > J Clin Microbiol. 1997 Jan;35(1):111-6.

> > > > > >

> > > > > > Persistence of Borrelia burgdorferi in

experimentally

> > > > infected

> > > > > > dogs after antibiotic treatment.

> > > > > >

> > > > > > Straubinger RK, Summers BA, Chang YF, Appel MJ.

> > > > > >

> > > > > > A. Baker Institute for Animal Health, College

of

> > > > > Veterinary

> > > > > > Medicine, Cornell University, Ithaca, New York 14853,

USA.

> > > > > > rks4@c...

> > > > > >

> > > > > > In specific-pathogen-free dogs experimentally

infected

> > with

> > > > > > Borrelia burgdorferi by tick exposure, treatment with

high

> > > doses

> > > > of

> > > > > > amoxicillin or doxycycline for 30 days diminished but

> failed

> > to

> > > > > > eliminate persistent infection. Although joint disease

was

> > > > > prevented

> > > > > > or cured in five of five amoxicillin- and five of six

> > > > > > doxycycline-treated dogs, skin punch biopsies and

multiple

> > > > tissues

> > > > > > from necropsy samples remained PCR positive and B.

> > burgdorferi

> > > > was

> > > > > > isolated from one amoxicillin- and two doxycycline-

treated

> > dogs

> > > > > > following antibiotic treatment. In contrast, B.

> burgdorferi

> > was

> > > > > > isolated from six of six untreated infected control dogs

> and

> > > > joint

> > > > > > lesions were found in four of these six dogs. Serum

> antibody

> > > > > levels to

> > > > > > B. burgdorferi in all dogs declined after antibiotic

> > treatment.

> > > > > > Negative antibody levels were reached in four of six

> > > doxycycline-

> > > >

> > > > > and

> > > > > > four of six amoxicillin-treated dogs. However, in dogs

> that

> > > were

> > > > > kept

> > > > > > in isolation for 6 months after antibiotic treatment was

> > > > > discontinued,

> > > > > > antibody levels began to rise again, presumably in

> response

> > to

> > > > > > proliferation of the surviving pool of spirochetes.

> Antibody

> > > > > levels in

> > > > > > untreated infected control dogs remained high.

> > > > > >

> > > > > > PMID: 8968890

[Guest guest]

There is a little envelope under my name, you can email me by way of

that.

> > > > > > This is a paper I hadnt seen. Leave it to the vets of

> > Cornell

> > > to

> > > > > point

> > > > > > out reality to the MDs... good thing weve got a crack

team

> > of

> > > > > BSers to

> > > > > > deftly brush it under the rug.

> > > > > >

> > > > > > The doxy-group dogs took 20 mg/kg/d, which is like me

> > sucking

> > > > down

> > > > > > 1200 mg of doxy per day (however, dogs may excrete it

> faster

> > or

> > > > > > something... I dont know... but the investigators did

> > measure

> > > the

> > > > > > plasma drug levels, by bioassay, to make sure they

were

> > > > > sufficient).

> > > > > >

> > > > > > One of six doxy-treated dogs, kept in isolation,

developed

> > > > > symptomatic

> > > > > > arthritis despite the 30-day treatment! And remained

> > culture+

> > > > and

> > > > > PCR+.

> > > > > >

> > > > > > This pisses me right off!

> > > > > >

> > > > > > ==============================

> > > > > >

> > > > > > J Clin Microbiol. 1997 Jan;35(1):111-6.

> > > > > >

> > > > > > Persistence of Borrelia burgdorferi in

experimentally

> > > > infected

> > > > > > dogs after antibiotic treatment.

> > > > > >

> > > > > > Straubinger RK, Summers BA, Chang YF, Appel MJ.

> > > > > >

> > > > > > A. Baker Institute for Animal Health,

College of

> > > > > Veterinary

> > > > > > Medicine, Cornell University, Ithaca, New York 14853,

USA.

> > > > > > rks4@c...

> > > > > >

> > > > > > In specific-pathogen-free dogs experimentally

infected

> > with

> > > > > > Borrelia burgdorferi by tick exposure, treatment with

high

> > > doses

> > > > of

> > > > > > amoxicillin or doxycycline for 30 days diminished but

> failed

> > to

> > > > > > eliminate persistent infection. Although joint disease

was

> > > > > prevented

> > > > > > or cured in five of five amoxicillin- and five of six

> > > > > > doxycycline-treated dogs, skin punch biopsies and

multiple

> > > > tissues

> > > > > > from necropsy samples remained PCR positive and B.

> > burgdorferi

> > > > was

> > > > > > isolated from one amoxicillin- and two doxycycline-

treated

> > dogs

> > > > > > following antibiotic treatment. In contrast, B.

> burgdorferi

> > was

> > > > > > isolated from six of six untreated infected control

dogs

> and

> > > > joint

> > > > > > lesions were found in four of these six dogs. Serum

> antibody

> > > > > levels to

> > > > > > B. burgdorferi in all dogs declined after antibiotic

> > treatment.

> > > > > > Negative antibody levels were reached in four of six

> > > doxycycline-

> > > >

> > > > > and

> > > > > > four of six amoxicillin-treated dogs. However, in dogs

> that

> > > were

> > > > > kept

> > > > > > in isolation for 6 months after antibiotic treatment

was

> > > > > discontinued,

> > > > > > antibody levels began to rise again, presumably in

> response

> > to

> > > > > > proliferation of the surviving pool of spirochetes.

> Antibody

> > > > > levels in

> > > > > > untreated infected control dogs remained high.

> > > > > >

> > > > > > PMID: 8968890

>

>

>

>

> -------------------------------------------------------------------

-----------

>

[Guest guest]

Sorry, Jelly. There is no such envelope on my email program (i.e., it does not appear on what I receive).

I really wanted some details of your experience because they might be helpful to a friend of mine who is in a similar position as yours was.

[infections] Re: Bb isolated from dogs after 30 days high-dose abx

There is a little envelope under my name, you can email me by way of that.> > > > > > This is a paper I hadnt seen. Leave it to the vets of > > Cornell > > > to > > > > > point> > > > > > out reality to the MDs... good thing weve got a crack team > > of > > > > > BSers to> > > > > > deftly brush it under the rug.> > > > > > > > > > > > The doxy-group dogs took 20 mg/kg/d, which is like me > > sucking > > > > down> > > > > > 1200 mg of doxy per day (however, dogs may excrete it > faster > > or> > > > > > something... I dont know... but the investigators did > > measure > > > the> > > > > > plasma drug levels, by bioassay, to make sure they were > > > > > sufficient). > > > > > > > > > > > > One of six doxy-treated dogs, kept in isolation, developed > > > > > symptomatic> > > > > > arthritis despite the 30-day treatment! And remained > > culture+ > > > > and > > > > > PCR+.> > > > > > > > > > > > This pisses me right off! > > > > > > > > > > > > ==============================> > > > > > > > > > > > J Clin Microbiol. 1997 Jan;35(1):111-6.> > > > > > > > > > > > Persistence of Borrelia burgdorferi in experimentally > > > > infected> > > > > > dogs after antibiotic treatment.> > > > > > > > > > > > Straubinger RK, Summers BA, Chang YF, Appel MJ.> > > > > > > > > > > > A. Baker Institute for Animal Health, College of > > > > > Veterinary> > > > > > Medicine, Cornell University, Ithaca, New York 14853, USA.> > > > > > rks4@c...> > > > > > > > > > > > In specific-pathogen-free dogs experimentally infected > > with> > > > > > Borrelia burgdorferi by tick exposure, treatment with high > > > doses > > > > of> > > > > > amoxicillin or doxycycline for 30 days diminished but > failed > > to> > > > > > eliminate persistent infection. Although joint disease was > > > > > prevented> > > > > > or cured in five of five amoxicillin- and five of six> > > > > > doxycycline-treated dogs, skin punch biopsies and multiple > > > > tissues> > > > > > from necropsy samples remained PCR positive and B. > > burgdorferi > > > > was> > > > > > isolated from one amoxicillin- and two doxycycline-treated > > dogs> > > > > > following antibiotic treatment. In contrast, B. > burgdorferi > > was> > > > > > isolated from six of six untreated infected control dogs > and > > > > joint> > > > > > lesions were found in four of these six dogs. Serum > antibody > > > > > levels to> > > > > > B. burgdorferi in all dogs declined after antibiotic > > treatment.> > > > > > Negative antibody levels were reached in four of six > > > doxycycline-> > > > > > > > > and> > > > > > four of six amoxicillin-treated dogs. However, in dogs > that > > > were > > > > > kept> > > > > > in isolation for 6 months after antibiotic treatment was > > > > > discontinued,> > > > > > antibody levels began to rise again, presumably in > response > > to> > > > > > proliferation of the surviving pool of spirochetes. > Antibody > > > > > levels in> > > > > > untreated infected control dogs remained high.> > > > > > > > > > > > PMID: 8968890> > > > > ------------------------------------------------------------------------------>