Al, Rich - SPECT Scans & Cardiac Link?

[Guest guest]

I feel vasculitis should be another leading suspect. This could cause

poor perfusion in the brain. And, as Cheney brainstorms, it could

self-intensify, if poor perfusion of the heart were itself to

compromise heart function and thence circulation, in a vicous cycle.

Microvasculitis impacts perfusion by simply deforming/narrowing the

capillaries. Endothelial (vessel wall) cells swell and reproduce

abnormally. This has the potential to completely stagnate the capillary.

Vasculitis and perivasculitis are the most ubiquitous lesions of

syphilis. Vasculitis has also been found often in lyme in many cases.

(I dont know for sure of any whole tissue histology of lyme; if there

were any I wonder if vasculitis *might* be found to in fact feature in

every case. I get a vague sense that histology of needle biopsy

samples may not be as good as autopsy in some ways, but I am

uncertain. I do not remember whether all the lyme histology I know of

is on needle-biopsy material).

Al, I didnt know Goldstein had shown hypoperfusion via SPECT - thats

very interesting. Do you know why this finding didnt silence the

psychologizing school of CFS/ME? Do you know of any non-needle

histology on CFS/ME or chronic borreliosis? I have looked a bit but

found little. The only CFS histology I found was muscle biopsies where

myocytes (muscle cells) were primarily examined. One would think the

investigators would have noticed any vasculitis if present but who

knows. Rich, you really know CFS literature so perhaps you have some

insight?

>

> > Hi all,

> >

> > The SPECT Brain Scans that were done in the early 90's by Jay

> Goldstein & others on CFS patients showed

> > Hypoperfusion (Low Blood Flow).

> >

> > As a result of the Peckerman study, Dr. Cheney says the result of

> the low cardiac output in CFS is poor micro-circulation . It would

> appear that this is what caused the Hypoperfusion in the SPECT

> Scans. Right ?

> >

> >

> > Al