Re: Candida, (Competition for nutrients)

[Guest guest]

Here's some interesting hypothesis..

Yeast Competition for CoQ10:

Ref #1)

Selenium deficiency resulting in lower glutathione and COQ10

Ref #2)

Selenium deficiency, neutrophils and increased candidasis

Ref #3)

__________________________________________________________________

REF #1)

Does gastrointestinal Candida albicans prevent ubiquinone absorption?

Krone CA, Elmer GW, Ely JT, Fudenberg HH, Thoreson J.

Applied Research Institute, PO Box 1925, Palmerston North, New

Zealand. cakrone@...

Ubiquinones (coenzyme Qs (CoQ)) are essential for oxidative

phosphorylation in yeasts and humans, although the isomers present in

each are different. The human coenzyme Q, CoQ10, is administered

orally for the treatment of heart disease and other disorders. Some

patients, however, require much higher doses than others to attain a

therapeutic CoQ10 blood level. We propose that one possible

explanation for this variability is Candida colonization of the GI

tract. Many common medical treatments including antibiotics and anti-

hyperchlorhydric agents increase the risk of GI tract Candida

colonization. Subsequent uptake and utilization of supplemental CoQ10

by the yeast could diminish availability for the human subject. Data

from one patient and an in vitro pilot study using two pathogenic

strains of C. albicans support this hypothesis. If C. albicans in the

GI tract can hinder availability and interfere with therapeutic

effects of CoQ10, it could be of clinical significance for large

numbers of patients. Copyright 2001 Harcourt Publishers Ltd.

PMID: 11735312 [PubMed - indexed for MEDLINE]

REF #2)

Biochem Biophys Res Commun. 1993 Feb 15;190(3):921-6

Decreased ubiquinone levels in tissues of rats deficient in selenium.

Vadhanavikit S, Ganther HE.

Department of Preventive Medicine and Community Health, University of

Texas Medical Branch, Galveston 77555.

The effect of selenium deficiency (-Se) on the levels of ubiquinones

in liver, heart, kidney, and leg muscle was studied in the rat.

Levels of ubiquinone 9 and ubiquinone 10 in the liver of -Se rats

were about 50% of the levels in selenium adequate animals. Both

ubiquinones in the heart were about 15% lower in -Se rats. Only

ubiquinone 9 was significantly lower in the kidney of -Se rats. There

was no difference in ubiquinone levels in leg muscle. Glutathione

peroxidase activity in the tissues of -Se rats was > 95% lower. It is

concluded that Se, as an integral part of the enzyme glutathione

peroxidase, may protect tissues from oxidative damage, thereby

preserving the ability of the cells to synthesize ubiquinone and

preventing ubiquinone from oxidative degradation.

PMID: 8439341 [PubMed - indexed for MEDLINE]

Reference # 3)

Indian J Biochem Biophys. 1994 Oct;31(5):427-9.

Effect of experimental selenium deficiency and its supplementation on

the candidacidal activity of neutrophils in albino rats.

Kukreja R, Khan A.

Department of Biochemistry, Nagpur University.

The role of selenium in the diet of rats has been examined with

respect to the neutrophil functions. Feeding of Se-deficient diet for

75 days resulted in reduction in candidacidal activity, superoxide

production, oxygen consumption, glucose utilisation and glutathione

peroxidase activity. Supplementing the diet with Se for 30 days

resulted in partial restoration of all the activities.

PMID: 7851945 [PubMed - indexed for MEDLINE]