Re: why do some pathogens aerosolize from hosts?

[Guest guest]

Your shedding bacteria all the time, If I want a sample of your sinus

bacteria I can place a culture dish into your bedroom without you

being around and grap a sample.There's also 50 billion orgasnisms

involved in a tuberculosis infection the healthy carriers may have

lesser numbers. Generally with infectiuons it requires a concentrated

large amount to make one ill. This was told to me by someone making

culture plates, he said they no longer sell to schools because kids

where picking up infections from unnaturally occuring concentrations

of bugs.

> Anyone know the basic principle? Why does, for example, MTB

aerosolize

> from the infected host? I presume the MTB-containing micron-scale

> droplets said to be emitted during coughing, talking, etc are also

> emitted by humans not suffering from tuberculosis, so the question

> seems to be how the bugs get into the droplets. Is it a matter of

the

> bacteria being present extracellularly on the air-exposed side of

the

> alveolar epithelium?

[Guest guest]

Yeah, my prof said they used to culture strep pyogenes from peoples

throats in micro to showcase the little known fact that at any given

time ~15% of people are carrying it there asymptomatically. But that

kinda thing aint cool anymore.

The people with asymptomatic MTB infection have very few bacteria,

well-contained in granuloma in most cases if I understand aright. I

hear there are over a billion humans with the infection - very few of

those have disease.

Median infective doses vary with the host species, microbe species,

and route of intrusion. (And of course other factors like whether

youve just stayed awake for 2 weeks and drank a prednisone milkshake,

or whatever.) Eg, the median infectious dose of Treponema pallidum in

man is MIGHTY low, under 10 organisms. Therefore (observing that the

organisms are abundant in primary and possibly also secondary

lesions) it is rather obvious that they must survive quite poorly

outside the body, at least in dry conditions, which was verified

experimentally according to a good-sense-sounding ~1945 clinical

manual I read.

> > Anyone know the basic principle? Why does, for example, MTB

> aerosolize

> > from the infected host? I presume the MTB-containing micron-scale

> > droplets said to be emitted during coughing, talking, etc are

also

> > emitted by humans not suffering from tuberculosis, so the

question

> > seems to be how the bugs get into the droplets. Is it a matter of

> the

> > bacteria being present extracellularly on the air-exposed side of

> the

> > alveolar epithelium?

[Guest guest]

I still think that it go's back to concentration levels. I also like

the 50's microbial literature because the whole world was focused on

pathogens. well into the 60-'s and 70's they declared the war on

bacteria won after having an arsenal of many differing types of

abx's.

I would only think you'd get an allergic type reaction from small

bacterial counts.All my microbiology books point to swarming amounts

of bacteria causing infections.I basically think it takes alot to

put us down it's not easily done,as you'll observe with many healthy

carriers of your borrelia organsims. I think one that stoodout was

the timberworkers.

I also feel no-one addresses in any literature the oppurtunistic

bacterial species which are all over your body in large numbers. If

your a sickly type your bacterial counts of oppurtunists are

possably already thru the roof.

tony

> > > Anyone know the basic principle? Why does, for example, MTB

> > aerosolize

> > > from the infected host? I presume the MTB-containing micron-

scale

> > > droplets said to be emitted during coughing, talking, etc are

> also

> > > emitted by humans not suffering from tuberculosis, so the

> question

> > > seems to be how the bugs get into the droplets. Is it a matter

of

> > the

> > > bacteria being present extracellularly on the air-exposed side

of

> > the

> > > alveolar epithelium?