Re: Aspirin- effects on therapy with Flagyl/Rifampin

[Guest guest]

Barb

that was a killer post. I alway's observe the anti inflammatories

and look for there bacteria killing/inhibiting.Unfortunately they

can also become completely resistant.

But if using an antibiotic succesfullyu and the aspirin can prevent

that mutation step it shows alot of promise.

tony

> Love the name of the publication.

> Barb

>

> Gut. 2003 Apr;52(4):490-5.

> Aspirin inhibits the growth of Helicobacter pylori and enhances

its

> susceptibility to antimicrobial agents.

>

> Wang WH, Wong WM, Dailidiene D, Berg DE, Gu Q, Lai KC, Lam SK,

Wong

> BC.

>

> Department of Gastroenterology, First Hospital, Peking University,

> Beijing, China. bcywong@h...

>

> BACKGROUND AND AIM: The role of Helicobacter pylori and aspirin in

> peptic ulcer formation and recurrence remains an important

clinical

> topic. The interaction between aspirin and H pylori in vitro is

also

> not clear. We investigated the effect of aspirin on the growth of

H

> pylori and on the susceptibility of H pylori to antimicrobials.

> METHODS: Time killing studies of H pylori were performed with

> different concentrations of aspirin and salicylate. Growth of

> bacteria was assessed spectrophotometrically and by viable colony

> count. The effects of aspirin on the efficiency of colony

formation

> and on metronidazole induced mutation to rifampicin resistance in

H

> pylori were determined. Minimal inhibitory concentrations (MICs)

of

> aspirin and metronidazole were tested by the standard agar

dilution

> method. MICs of amoxycillin and clarithromycin were determined by

the

> E test method. RESULTS: Aspirin and salicylate inhibited the

growth

> of H pylori in a dose dependent manner and bactericidal activity

was

> due to cell lysis. Aspirin 400 micro g/ml caused a 2 logs decrease

in

> colony forming units/ml at 48 hours, and suppressed the normal

> ability of metronidazole to induce new mutations to rifampicin.

The IC

> (90) of aspirin was 512 micro g/ml. Increased susceptibility of

> amoxycillin, clarithromycin, and metronidazole to H pylori was

> observed at 1 mM (180 micro g/ml) aspirin.

>

> CONCLUSIONS: Aspirin inhibited the growth of H pylori, suppressed

the

> mutagenic effect of metronidazole, and enhanced the susceptibility

of

> H pylori to antimicrobial agents. This mechanism is important in

> future drug development for effective clearing and overcoming

> resistance.

>

> PMID: 12631656 [PubMed - indexed for MEDLINE

[Guest guest]

Yeah, I've read in more than one place how aspirin works as an

antimicrobial. Talk about killing three birds with one stone, it

works on inflammation AND microbes AND thins the blood.

Geez, I wish I could take it. It just KILLS my stomach, and I don't

know how to get past that. It's weird too, because my stomach can

tolerate most things that cause people problems, but all the aspirin

related products cause me such pain.

I mean, aspirin kills the microbes that cause ulcers, but it can

also CAUSE ulcers? How does that work?

penny

> Love the name of the publication.

> Barb

>

> Gut. 2003 Apr;52(4):490-5.

> Aspirin inhibits the growth of Helicobacter pylori and enhances

its

> susceptibility to antimicrobial agents.

>

> Wang WH, Wong WM, Dailidiene D, Berg DE, Gu Q, Lai KC, Lam SK,

Wong

> BC.

>

> Department of Gastroenterology, First Hospital, Peking University,

> Beijing, China. bcywong@h...

>

> BACKGROUND AND AIM: The role of Helicobacter pylori and aspirin in

> peptic ulcer formation and recurrence remains an important

clinical

> topic. The interaction between aspirin and H pylori in vitro is

also

> not clear. We investigated the effect of aspirin on the growth of

H

> pylori and on the susceptibility of H pylori to antimicrobials.

> METHODS: Time killing studies of H pylori were performed with

> different concentrations of aspirin and salicylate. Growth of

> bacteria was assessed spectrophotometrically and by viable colony

> count. The effects of aspirin on the efficiency of colony

formation

> and on metronidazole induced mutation to rifampicin resistance in

H

> pylori were determined. Minimal inhibitory concentrations (MICs)

of

> aspirin and metronidazole were tested by the standard agar

dilution

> method. MICs of amoxycillin and clarithromycin were determined by

the

> E test method. RESULTS: Aspirin and salicylate inhibited the

growth

> of H pylori in a dose dependent manner and bactericidal activity

was

> due to cell lysis. Aspirin 400 micro g/ml caused a 2 logs decrease

in

> colony forming units/ml at 48 hours, and suppressed the normal

> ability of metronidazole to induce new mutations to rifampicin.

The IC

> (90) of aspirin was 512 micro g/ml. Increased susceptibility of

> amoxycillin, clarithromycin, and metronidazole to H pylori was

> observed at 1 mM (180 micro g/ml) aspirin.

>

> CONCLUSIONS: Aspirin inhibited the growth of H pylori, suppressed

the

> mutagenic effect of metronidazole, and enhanced the susceptibility

of

> H pylori to antimicrobial agents. This mechanism is important in

> future drug development for effective clearing and overcoming

> resistance.

>

> PMID: 12631656 [PubMed - indexed for MEDLINE