Re: Arsenic - soft third-hand patient testimony

[Guest guest]

I once did some deep googling on this (over 100 entries deep) and

found a patient-written document from the era of Tarellos paper (late

1990s I think). I can recall with 80% confidence that what the author

said was that he was aware of one report of arsenic not doing much for

CFS, and one other reporting a good improvement (but not resolution).

This information was not detailed, rather it was virtually as summary

as it is in my above re-telling.

This document gave no specific information on the compounds or dosing

schedules used, nor stated specifically that Tarellos regime was followed.

Some contemporary information on arsenic toxicology may be available

in contemporary papers regarding its use in certain cancers. This use

seems to have spread to the US from (at least) China.

<mpalmer@u...> wrote:

> I've looked into arsenic a bit. It has a colorful history. Still not

> sure what to make of it.

>

> There are claims that arsenic is a psychostimulant and I worry

> that such an effect could be misinterpreted as evidence of

> reduced bacterial load. " The Arsenic Eaters " must have felt

> some sort of benefit, but I haven't taken the time to really

> investigate this.

>

> I'll side-step any debate over toxicity by pointing out that the

> efficacy of arsenic against bacteria is qualified by a number of

> factors.

>

> Low amounts of arsenic commonly occur in the environment.

> Microbes have responded to this by encoding arsenic

> resistance. I won't give citations for this. You can find volumes

> on this by searching for " arsenic resistance " , " ars operon " , etc.

> Often these genes occur on plasmids and in some cases these

> plasmids can be transferred from one species of bacteria to

> another.

>

> This paper:

>

> http://tinyurl.com/cybam

>

> PMID: 2733075

>

> reports that about 95% of the 62 clinical isolates of Staph from a

> chinese hospital were resistant to arsenic. Perhaps the water

> in that region is high in arsenic, leading to high-level resistance,

> in which case it may not be relevant to people living in other

> areas.

>

> Furthermore, this paper:

>

> http://tinyurl.com/cr746

>

> PMID: 11391480

>

> shows that 48 to 72 hours of exposure to 5 mM arsenic (followed

> by removal of the arsenic) induced resistance, in Yersinia

> enterocolitica, to multiple antibiotics.

>

> I can't tell from this what the likelihood is of a similar effect

> occurring in more relevant species, but it does suggest the

> complexity of arsenic use.

>

> Matt

>

>

>

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