Re: S. ARBS/potassium and Ion gates (plus Neurontin)

[Guest guest]

Possibly the change in potassium status on high dose ARBS is the key?

I've done a quick search..

I have not read in depth though..

here are the sites.

Barb

QUOTE :The key receptor in the central nervous system for pain

modulation is the NMDA receptor. Glutamate and Glycine have been

found to be important NMDA stimulants. They work on the NMDA recepto

by opening its voltage dependant channels at the cell membrane level.

There are also Non-NMDA receptors. One important one is called the

AMPA receptor. N-methyl-D-aspartate is an example of an AMPA receptor

stimulant. AMPA receptors are typically found near NMDA receptors.

....... In fact all receptors are functionally dependant on the

status of thir voltage dependant channels, or gates. These gates are

typically specific for minerals such as calcium, magnesium, potassium

or sodium.END QUOTE

REF:http://www.homestead.com/scrsda/Neuropathicpain.html

ARBS/potassium current:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=PubMed & dopt=Abstract & list_uids=10715269

ion gates/Voltage

http://www.krasnow.gmu.edu/ascoli/Teaching/Psyc372_01/hw3.htm

http://www.bu.edu/ndl/people/burton/slides/NMDA/NMDA.html

> > Hello again,

> >

> > This is Pope scha, your blab-artist in residence, reporting

live

> > from the field, where I have just had an utterly horrifying

thought

> > about ARBs and why I have gotten so much worse on them.

> >

> > In my previous three posts, I discuss neurontin, a drug intended

to

> > relieve nerve pain, that has a very uneven effectiveness from

> > patient to patient, because of difficulty metabolozing it.

> >

> > I have reported here previously how, while under the sway of the

> > Unnameable Protocol, I combined the maximum dose of my blood-

> > pressure medicine, an ARB very much like Benicar, with a regimen

of

> > strict D and sun deprivation. During that period, all my worst

> > symptoms became much more severe, and new ones manifested.

> >

> > Penny had exactly the opposite response. Benicar relieved many of

> > her worst symptoms with no discernible side-effect.

> >

> > Here is my hypothesis about why I responded so badly, compared to

> > Penny:

> >

> > a) Neurontin might have helped me, had I not been prescribed the

> > maximum dose of Diovan, an ARB like Benicar, for hypertension.

> >

> > Neurontin is not properly metabolized in patients with renal

> > insufficiency, who may need to multiply the dose by a large

factor.

> >

> > c) ARBs can cause or aggravate renal insufficiency in susceptible

> > patients.

> >

> > e) If I find out ARBs are also limiting Gabitril or Morphine in

my

> > body you will hear me screaming about it halfway across the

planet.

> >

> > f) What is certain is:

> >

> > ** a complete failure to respond to 3 grams of Neurontin a day

after

> > several months is unusual in someone with a very high level of

nerve-

> > based pain;

> >

> > ** the high dose of Diovan provides a logical explanation.

> >

> > g) It is a known fact that MS symptom exacerbation cycles are

> > moderated by D3.

> >

> > h) In MS, the main source of cognitive slowing, sensory

distortion,

> > fatigue and other symptoms is related to extracellular glutamate

> > building up, especially around the nerve roots.

> >

> > i) Logically, we are obliged to consider whether D3 does not

> > increase glutamate transport, and moderate symptom increases in

this

> > way.

> >

> > j) If that is so, the combination of neutralizing Neurontin with

the

> > ARB and increasing glutamate build up with D-deprivation could

have

> > done me a pretty spectacular level of harm.

> >

> > I know that's long and not easy to follow, but some of you will

get

> > it and I am curious to know what you think. Neurontin is a COMMON

> > NDMA receptor antagonist. Neurontin is used to treat a very large

> > portion of patients seen for nerve-related pain, a staple drug in

> > regimens for neuro-Lyme, fibromyalgia, and other diseases which

the

> > Unnameable Protocol claims to treat effectively. If ARBs turn

out to

> > render it biololgically inactive, those patients will be well-

> > advised to stay the hell away from it (which is good advice

anyway).

> >

> > i) ARB enthusiasts REALLY need to cut back on their sweeping

> > pronouncements. These drugs may do some of us incalculable harm.

> >

> > That doesn't make Penny's response less important, but it is NOT

> > typical - at least half of those on the massive ARB doses of the

> > Unnameable Protocol experience little or no symptomatic relief.

> >

> > j) It is likely in my mind that those of us whose symptoms

respond

> > to ARBs make up no more than 40% of all ACID patients, and of

those

> > there may be as many in ARB agony as there are in ARB ecstasy.

> >

> > Those of us whose symptoms respond not at all or adversely to

ARBs

> > talk about them less, for the simple reason that we find them

less

> > worth talking about.

> >

> > Cheers,

> >

> > Scha

> >

> >

> >

> >

> >

> >