Memo To Hodologica re: Fluconazole and NeuroLyme

[Guest guest]

Memo To Hodologica

Saturday, May 14, 2005

Dear ,

I am pondering these reports of success with Fluconazole treatment

for neuro-borreliosis. I am thinking that the mechanism is probably

worth exploring, at least a little, to see if have any clues that we

might have overlooked.

Specifically, I'm thinking about how in different ways most of these

anti-fungal drugs block cholesterol synthesis and what that means

for their use. The statins we use for cholesterol management and

inflammation reduction also block cholesterol synthesis, and there

is a rumor which may be true that the descend from early antifungal

drugs.

Presumably then one would want to look closely at how Borrelia

utilize cholesterol. This is likely a somewhat different question,

depending on whether we look at extracellular or intracellular

localization.

Assuming for the sake of argument that Fluconazole really is doing

something to impair Borrelia, and further assuming that cholesterol

synthesis is vital to the mechanism, what might we look at among the

known or suspected qualities of these bugs?

I am sure you have a better mind for this kind of question now than

I do.

Your friend,

scha