Re: Memo To Hodologica re: Fluconazole and NeuroLyme

[Guest guest]

Wherefrom do you have it for sure that they block the cholesterol

pathway?

I was learning about the azoles a bit and had posted a couple links,

but that was right before I & I-1 got shut down.

I heard they act against fungi by blocking ergosterol synth - I didnt

know about them affecting cholesterol. I wasnt able to learn whether

their proximal toxicity to fungi was due to substrates of the drug-

inhibited CYP 450 enzyme building up to toxic levels, or instead due

to ergosterol-deprivation.

The spirochaetae are more lipid-rich than your average bacteria. But

I am not sure how much of this lipid content is sterols, and which

ones.

As a general spirochete update, I am still interested in the

possibility that they might exist primarily extracellularly as

classical forms. I was excited to find today that Mattman refers to a

paper as showing strong evidence that T pallidum is primarily

intracellular and L-form, which is certainly contrary to the opinion

of todays authors, tho not of certain old-timers like Warthin. I cant

wait to check it out but wont be free till tuesday.

<compucruz@y...> wrote:

> Memo To Hodologica

>

> Saturday, May 14, 2005

>

> Dear ,

>

> I am pondering these reports of success with Fluconazole treatment

> for neuro-borreliosis. I am thinking that the mechanism is probably

> worth exploring, at least a little, to see if have any clues that

we

> might have overlooked.

>

> Specifically, I'm thinking about how in different ways most of

these

> anti-fungal drugs block cholesterol synthesis and what that means

> for their use. The statins we use for cholesterol management and

> inflammation reduction also block cholesterol synthesis, and there

> is a rumor which may be true that the descend from early antifungal

> drugs.

>

> Presumably then one would want to look closely at how Borrelia

> utilize cholesterol. This is likely a somewhat different question,

> depending on whether we look at extracellular or intracellular

> localization.

>

> Assuming for the sake of argument that Fluconazole really is doing

> something to impair Borrelia, and further assuming that cholesterol

> synthesis is vital to the mechanism, what might we look at among

the

> known or suspected qualities of these bugs?

>

> I am sure you have a better mind for this kind of question now than

> I do.

>

> Your friend,

>

> scha

[Guest guest]

I do know that cell wall deficient bacteria must have

cholesterol to survive. You are on to something with

this line of thought. Jimd

--- Schaafsma <compucruz@...> wrote:

> Memo To Hodologica

>

> Saturday, May 14, 2005

>

> Dear ,

>

> I am pondering these reports of success with

> Fluconazole treatment

> for neuro-borreliosis. I am thinking that the

> mechanism is probably

> worth exploring, at least a little, to see if have

> any clues that we

> might have overlooked.

>

> Specifically, I'm thinking about how in different

> ways most of these

> anti-fungal drugs block cholesterol synthesis and

> what that means

> for their use. The statins we use for cholesterol

> management and

> inflammation reduction also block cholesterol

> synthesis, and there

> is a rumor which may be true that the descend from

> early antifungal

> drugs.

>

> Presumably then one would want to look closely at

> how Borrelia

> utilize cholesterol. This is likely a somewhat

> different question,

> depending on whether we look at extracellular or

> intracellular

> localization.

>

> Assuming for the sake of argument that Fluconazole

> really is doing

> something to impair Borrelia, and further assuming

> that cholesterol

> synthesis is vital to the mechanism, what might we

> look at among the

> known or suspected qualities of these bugs?

>

> I am sure you have a better mind for this kind of

> question now than

> I do.

>

> Your friend,

>

> scha

>

>

>

>

__________________________________

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Take with you! Check email on your mobile phone.

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[Guest guest]

Hi Jim, thanks for mentioning about the CWD, because that is partly

what prompted my question. I have a distinct memory of reading about

this and how some researcher thought it might impact certain

hormones for which cholesterol is one necessary precursor.

, I think if you look into the relationship of ergosterol and

cholesterol you may find something that helps us on this.

I look forward to hearing more about this. I believe it may figure

in what two LLMDs have now told me is a broad trend toward

testosterone and cortisol deficiency, not in all patients but in a

very high and disproportionate number. Both testosterone and

cortisol have cholesterol as a precursor, which makes sense if one

looks at the word, whose second half is " sterol. "

I think there might be something worth looking at, tying these

threads together in a way that hasn't yet been done in the published

papers I've read.

> > Memo To Hodologica

> >

> > Saturday, May 14, 2005

> >

> > Dear ,

> >

> > I am pondering these reports of success with

> > Fluconazole treatment

> > for neuro-borreliosis. I am thinking that the

> > mechanism is probably

> > worth exploring, at least a little, to see if have

> > any clues that we

> > might have overlooked.

> >

> > Specifically, I'm thinking about how in different

> > ways most of these

> > anti-fungal drugs block cholesterol synthesis and

> > what that means

> > for their use. The statins we use for cholesterol

> > management and

> > inflammation reduction also block cholesterol

> > synthesis, and there

> > is a rumor which may be true that the descend from

> > early antifungal

> > drugs.

> >

> > Presumably then one would want to look closely at

> > how Borrelia

> > utilize cholesterol. This is likely a somewhat

> > different question,

> > depending on whether we look at extracellular or

> > intracellular

> > localization.

> >

> > Assuming for the sake of argument that Fluconazole

> > really is doing

> > something to impair Borrelia, and further assuming

> > that cholesterol

> > synthesis is vital to the mechanism, what might we

> > look at among the

> > known or suspected qualities of these bugs?

> >

> > I am sure you have a better mind for this kind of

> > question now than

> > I do.

> >

> > Your friend,

> >

> > scha

> >

> >

> >

> >

>

>

>

> __________________________________

> Mobile

> Take with you! Check email on your mobile phone.

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