Re: Jaep - Follow up question for J

[Guest guest]

Hi , I was sure we would hear from you about the post by Nelly,

on Donta's notion about metabolic products from gut flora. I assume

that's what you're referring to as " yesterday's debate? "

I was curious about gliotoxin. Are there studies that show just

which parts of the IS are suppressed?

All immune responses are not created equal, and knowing which ones

tend to be suppressed by yeast overgrowth would be interesting.

Since some yeast is always present, presumably the Immune System has

adapted to some amount of gliotoxin in circulation?

If I understand the Donta reference (doubtful, it wasn't real clear

to me), he was saying that some adverse neurological effect was

triggered by the metabolic products. Are you thinking that is

process is a) " real " and immune mediated?

Sorry if I'm just confusing things. You may have had something other

than Nelly's post in mind.

Other

>

> Hi Matt , glad you found my web site useful... & thanks for the

info on

> Amiodarone, I'm glad to see there is some research going on but as

far as

> personal experience ,I haven't any .The docs don't acknowledge

yeast as a

> serious illness anyway so getting access to the drug is would be

difficult

> to say the least.. I will say I don't think a magic bullet type

solution is

> feasible with yeast infections . Its more complex than just a

single

> infection ..the fact that you have a yeast infection makes it a

certainty

> that other opportunistic pathogens will have invaded ..a substance

called

> gliotoxin is produced by all fungi ,its a powerful immunemodulater

it

> depresses the IS > The debate yesterday on how toxins from duff

microbes

> have a profound effect on health is right on the button... & yeast

is number

> one in producing toxins ..how we restore our gut flora to me is

the most

> important issue ,we should have 95% Lactic acid bacteria gut

flora ,our IS

> is compromised with anything less...So..couple of sites.

>

> " Circulating gliotoxin levels may be of value in diagnosing

Aspergillus

> infection " that will hold true for yeast , it maybe worth testing

for?

>

> http://www.bloodjournal.org/cgi/content/full/105/6/2239

>

>

http://www.altcorp.com/AffinityLaboratory/SlideShows/Gliotoxin/sld010

..htm

> [infections] Jaep

>

>

>

>

> I finally got around to looking into the fungal angle some, and

> really appreciate your web site.

>

> I've read several of the papers on the antifungal properties of

> amiodarone. They are fascinating.

>

> This paper:

>

> http://tinyurl.com/a8zyb

>

> PMID: 12754197

>

> shows impressive synergy of 2 to 4 uM amiodarone when

> combined with azoles. It says that this is " low, micromolar

> doses " . That's important because this drug is, frankly, a bit

> scary. Can have serious side-effects, interactions with

> antimycotics and antibiotics (and ARBs?) and has a very long

> half-life.

>

> But this paper:

>

> http://tinyurl.com/bvkzw

>

> PMID: 11752116

>

>

> says, " The plasma concentration of amiodarone that are used

> clinically for treatment of arrhythmia can be in the range of 1

to 4

> uM during loading periods. "

>

> That makes me think that 2 to 4 uM isn't so low.

>

> What is your take on this? Have you come across any testimony

> on the use of amiodarone to potentiate the azoles? Was it

> successful and were there adverse reactions? Are there any

> forums out there where people are discussing this?

>

> Thanks,

> Matt

>

>

>

>

>

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