Guest guest Posted May 2, 2005 Report Share Posted May 2, 2005 Hi Matt , glad you found my web site useful... & thanks for the info on Amiodarone, I'm glad to see there is some research going on but as far as personal experience ,I haven't any .The docs don't acknowledge yeast as a serious illness anyway so getting access to the drug is would be difficult to say the least.. I will say I don't think a magic bullet type solution is feasible with yeast infections . Its more complex than just a single infection ..the fact that you have a yeast infection makes it a certainty that other opportunistic pathogens will have invaded ..a substance called gliotoxin is produced by all fungi ,its a powerful immunemodulater it depresses the IS > The debate yesterday on how toxins from duff microbes have a profound effect on health is right on the button... & yeast is number one in producing toxins ..how we restore our gut flora to me is the most important issue ,we should have 95% Lactic acid bacteria gut flora ,our IS is compromised with anything less...So..couple of sites. "Circulating gliotoxin levels may be of value in diagnosing Aspergillus infection" that will hold true for yeast , it maybe worth testing for? http://www.bloodjournal.org/cgi/content/full/105/6/2239 http://www.altcorp.com/AffinityLaboratory/SlideShows/Gliotoxin/sld010.htm -----Original Message-----From: infections [mailto:infections ]On Behalf Of phagelodSent: 01 May 2005 22:42infections Subject: [infections] JaepI finally got around to looking into the fungal angle some, and really appreciate your web site.I've read several of the papers on the antifungal properties of amiodarone. They are fascinating.This paper:http://tinyurl.com/a8zybPMID: 12754197shows impressive synergy of 2 to 4 uM amiodarone when combined with azoles. It says that this is "low, micromolar doses". That's important because this drug is, frankly, a bit scary. Can have serious side-effects, interactions with antimycotics and antibiotics (and ARBs?) and has a very long half-life.But this paper:http://tinyurl.com/bvkzwPMID: 11752116says, "The plasma concentration of amiodarone that are used clinically for treatment of arrhythmia can be in the range of 1 to 4 uM during loading periods."That makes me think that 2 to 4 uM isn't so low.What is your take on this? Have you come across any testimony on the use of amiodarone to potentiate the azoles? Was it successful and were there adverse reactions? Are there any forums out there where people are discussing this?Thanks,Matt Quote Link to comment Share on other sites More sharing options...
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