RE: Re: Jaep - Follow up question for J

[Guest guest]

hi , Plenty of reading on gliotoxin in the site below, The connection with neuo symptoms is somewhat explained in the piece below , Gastro & immune probs as you see the two are interrelated

http://www.altcorp.com/AffinityLaboratory/fungistudies.htm

The digestive-immunological behavioural connection

The gut is composed of some neurotransmitters and other chemicals that are identical to those found in the brain. Gastrointestinal disturbances coincide with mental acuity and emotional stability. This has been shown to be the case among children along the autistic spectrum. Immune dysfunction and gastrointestinal problems are interrelated, and the treatments that have been shown to be the greatest successes are those that address these two biological systems. Gastrointestinal problems caused by immune dysfunction, which then result in mental and behavioural reactions, or immune dysfunction that causes gastrointestinal problems, which results in mental and behavioural reactions.

The body functions by properly utilizing what it needs and eliminating what it doesn’t need. Survival is dependent on the body’s recognition of what is value for growth and development and what is not. All the biological systems, down to the cellular level, are involved in these processes. Most of us take for granted that the nutrients found in the food that we eat will be properly assimilated and the ingredients that are not nutritious will be excreted. It is also assumed that toxins that invade our bodies from the air we breathe to the water we drink will be eliminated as well. For even relatively healthy adults, however, there are ways in which assimilation and elimination can be compromised, including the aging process. We may experience stomach, diarrhoea or constipation, a general lack of energy, arthritic tendencies and other signs depending on the severity of intestinal disturbance and toxic build up. Children experience the same discomforts, but because they are still growing, their brains can be affected by nutritional deficiencies, by food allergies and sensitivities, and by toxicity, resulting in cognitive and behavioural problems.

It is extremely important to assess the digestive function of children along the autistic spectrum. Improper digestion leads to immune suppression, making the body more susceptible to infections, and to immune dysfunction, which leads to adverse or allergic reactions to foods and the environment.

One type of digestive disorder that is often found among children with autistic behaviours and learning problems is increased intestinal permeability - ‘leaky gut’. The small intestine is the longest part of the digestive track. It is responsible of absorbing essential nutrients and preventing undesirable substances from entering through the intestinal lining into the bloodstream. The intestinal lining can be damaged by a number of factors including chronic bacterial, viral, and fungal infections, and by repeated use of antibiotics and nonsteroidal anti-inflammatory drugs such as aspirin and ibuprofen. It can also be damaged by an incompetent disposal system for toxic waste that is accumulated daily by the body. This damage results in tears in the lining, which enable otherwise impassable substances to reach the bloodstream. An increase in damage and tears allows undigested food particles to pass through the intestinal lining, which creates an immune reaction. The body responds as if being attacked by antigens. This immune response in growing children manifests as allergies to foods, which then take a behavioural form. Chronic allergic reactions tax all the biological systems, keep the immune system in alert status, creates bodily discomforts, and ultimately affects behaviour, sleep, mood, and ability to concentrate and learn. If left untreated, ‘leaky gut’ syndrome will overburden the liver’s ability to clean out toxins.

[infections] Jaep> > > > > I finally got around to looking into the fungal angle some, and> really appreciate your web site.> > I've read several of the papers on the antifungal properties of> amiodarone. They are fascinating.> > This paper:> > http://tinyurl.com/a8zyb> > PMID: 12754197> > shows impressive synergy of 2 to 4 uM amiodarone when> combined with azoles. It says that this is "low, micromolar> doses". That's important because this drug is, frankly, a bit> scary. Can have serious side-effects, interactions with> antimycotics and antibiotics (and ARBs?) and has a very long> half-life.> > But this paper:> > http://tinyurl.com/bvkzw> > PMID: 11752116> > > says, "The plasma concentration of amiodarone that are used> clinically for treatment of arrhythmia can be in the range of 1 to 4> uM during loading periods."> > That makes me think that 2 to 4 uM isn't so low.> > What is your take on this? Have you come across any testimony> on the use of amiodarone to potentiate the azoles? Was it> successful and were there adverse reactions? Are there any> forums out there where people are discussing this?> > Thanks,> Matt> > > > > > ----------------------------------------------------------------------------> -->