- cytokine promoter SNPs in CFS

[Guest guest]

this will interest you and anyone feeling that inflammation may

feed the infection.

Latest issue of Genes and Immunity has study showing higher frequency

of a high-producing TNF promotor SNP in CFS (p=.005) and lower-ish

frequency of a low-producing INFg promoter SNP (p=.04).

I think there may have been some links between these or similar

promoter SNPs and other idiopathic inflammopathies. But there may be

some controversy over how they apply to cytokine phenotypes? I know

very little here. I dont know about what all transcription factors are

involved in this and cant say this isnt all alot more complicated and

equivocal than it looks.

Anyway, the correlations arent all that powerful even if the p-values

do show the TNF finding is very unlikely to be a result of randomness.

But its interesting.