Re: More on opioids and glutamate

[Guest guest]

According to my very superficial knowledge, the interrelationships of

neurotransmitter level fluxes and neural activity vary thruout the

brain, so that while GABA signalling will reduce the firing of your

average neuron, it can in fact excite the neurons of certain loci.

This abstract seems to deal exlusively with the respiratory drive

center in the medula, so it would have been useful back when I had an

occasional interest in how much wine I could safely drink after

snorting one of my housemates Percosets. But I'm not sure what else to

say? Do you find that these multi-pharma and/or multi-signaling

interactions apply to analgesia? I am aware that there has been some

work on combining opiates with drugs that are mainly just NMDA

antagonists - I dont know how it turned out.

> Dr. Hodologica, you are being paged.

>

> Abstract: [paragraph breaks added]

> Addiction. 1999 Jul;94(7):961-72.

>

> Comment in:

> Addiction. 1999 Jul;94(7):973-4.

>

> Mechanisms of fatal opioid overdose.

[Guest guest]

A point of biology , which you may already know, is that even the

exact same receptor can be coupled to different (even opposite)

downstream responses in different cells. Not only may an X1 receptor

tend to exert different actions than an X2 receptor that binds the

same signal molecule X - it can also be the case that X1 activation

in/on cell type A has very different results from X1 activation in/on

cell type B. Even if A and B are both types of neurons.