Hypothetical adverse drug reaction with ARBs & D-deprivation

[Guest guest]

Hello again,

This is Pope scha, your blab-artist in residence, reporting live

from the field, where I have just had an utterly horrifying thought

about ARBs and why I have gotten so much worse on them.

In my previous three posts, I discuss neurontin, a drug intended to

relieve nerve pain, that has a very uneven effectiveness from

patient to patient, because of difficulty metabolozing it.

I have reported here previously how, while under the sway of the

Unnameable Protocol, I combined the maximum dose of my blood-

pressure medicine, an ARB very much like Benicar, with a regimen of

strict D and sun deprivation. During that period, all my worst

symptoms became much more severe, and new ones manifested.

Penny had exactly the opposite response. Benicar relieved many of

her worst symptoms with no discernible side-effect.

Here is my hypothesis about why I responded so badly, compared to

Penny:

a) Neurontin might have helped me, had I not been prescribed the

maximum dose of Diovan, an ARB like Benicar, for hypertension.

Neurontin is not properly metabolized in patients with renal

insufficiency, who may need to multiply the dose by a large factor.

c) ARBs can cause or aggravate renal insufficiency in susceptible

patients.

e) If I find out ARBs are also limiting Gabitril or Morphine in my

body you will hear me screaming about it halfway across the planet.

f) What is certain is:

** a complete failure to respond to 3 grams of Neurontin a day after

several months is unusual in someone with a very high level of nerve-

based pain;

** the high dose of Diovan provides a logical explanation.

g) It is a known fact that MS symptom exacerbation cycles are

moderated by D3.

h) In MS, the main source of cognitive slowing, sensory distortion,

fatigue and other symptoms is related to extracellular glutamate

building up, especially around the nerve roots.

i) Logically, we are obliged to consider whether D3 does not

increase glutamate transport, and moderate symptom increases in this

way.

j) If that is so, the combination of neutralizing Neurontin with the

ARB and increasing glutamate build up with D-deprivation could have

done me a pretty spectacular level of harm.

I know that's long and not easy to follow, but some of you will get

it and I am curious to know what you think. Neurontin is a COMMON

NDMA receptor antagonist. Neurontin is used to treat a very large

portion of patients seen for nerve-related pain, a staple drug in

regimens for neuro-Lyme, fibromyalgia, and other diseases which the

Unnameable Protocol claims to treat effectively. If ARBs turn out to

render it biololgically inactive, those patients will be well-

advised to stay the hell away from it (which is good advice anyway).

i) ARB enthusiasts REALLY need to cut back on their sweeping

pronouncements. These drugs may do some of us incalculable harm.

That doesn't make Penny's response less important, but it is NOT

typical - at least half of those on the massive ARB doses of the

Unnameable Protocol experience little or no symptomatic relief.

j) It is likely in my mind that those of us whose symptoms respond

to ARBs make up no more than 40% of all ACID patients, and of those

there may be as many in ARB agony as there are in ARB ecstasy.

Those of us whose symptoms respond not at all or adversely to ARBs

talk about them less, for the simple reason that we find them less

worth talking about.

Cheers,

Scha

[Guest guest]

Do me a favor. EMail me a detailed medical history, okay? I want to

think about it. I'm just a person but I do a lot of science writing

and I'm a smart person.

DO you have to be on the ARBs? How high is your blood pressure without

them?

[Guest guest]

interesting point is the renal problem. This is almost as the same

problem I had with sur-renals

>

> Hello again,

>

> This is Pope scha, your blab-artist in residence, reporting live

> from the field, where I have just had an utterly horrifying thought

> about ARBs and why I have gotten so much worse on them.

>

> In my previous three posts, I discuss neurontin, a drug intended to

> relieve nerve pain, that has a very uneven effectiveness from

> patient to patient, because of difficulty metabolozing it.

>

> I have reported here previously how, while under the sway of the

> Unnameable Protocol, I combined the maximum dose of my blood-

> pressure medicine, an ARB very much like Benicar, with a regimen of

> strict D and sun deprivation. During that period, all my worst

> symptoms became much more severe, and new ones manifested.

>

> Penny had exactly the opposite response. Benicar relieved many of

> her worst symptoms with no discernible side-effect.

>

> Here is my hypothesis about why I responded so badly, compared to

> Penny:

>

> a) Neurontin might have helped me, had I not been prescribed the

> maximum dose of Diovan, an ARB like Benicar, for hypertension.

>

> Neurontin is not properly metabolized in patients with renal

> insufficiency, who may need to multiply the dose by a large factor.

>

> c) ARBs can cause or aggravate renal insufficiency in susceptible

> patients.

>

> e) If I find out ARBs are also limiting Gabitril or Morphine in my

> body you will hear me screaming about it halfway across the planet.

>

> f) What is certain is:

>

> ** a complete failure to respond to 3 grams of Neurontin a day after

> several months is unusual in someone with a very high level of nerve-

> based pain;

>

> ** the high dose of Diovan provides a logical explanation.

>

> g) It is a known fact that MS symptom exacerbation cycles are

> moderated by D3.

>

> h) In MS, the main source of cognitive slowing, sensory distortion,

> fatigue and other symptoms is related to extracellular glutamate

> building up, especially around the nerve roots.

>

> i) Logically, we are obliged to consider whether D3 does not

> increase glutamate transport, and moderate symptom increases in this

> way.

>

> j) If that is so, the combination of neutralizing Neurontin with the

> ARB and increasing glutamate build up with D-deprivation could have

> done me a pretty spectacular level of harm.

>

> I know that's long and not easy to follow, but some of you will get

> it and I am curious to know what you think. Neurontin is a COMMON

> NDMA receptor antagonist. Neurontin is used to treat a very large

> portion of patients seen for nerve-related pain, a staple drug in

> regimens for neuro-Lyme, fibromyalgia, and other diseases which the

> Unnameable Protocol claims to treat effectively. If ARBs turn out to

> render it biololgically inactive, those patients will be well-

> advised to stay the hell away from it (which is good advice anyway).

>

> i) ARB enthusiasts REALLY need to cut back on their sweeping

> pronouncements. These drugs may do some of us incalculable harm.

>

> That doesn't make Penny's response less important, but it is NOT

> typical - at least half of those on the massive ARB doses of the

> Unnameable Protocol experience little or no symptomatic relief.

>

> j) It is likely in my mind that those of us whose symptoms respond

> to ARBs make up no more than 40% of all ACID patients, and of those

> there may be as many in ARB agony as there are in ARB ecstasy.

>

> Those of us whose symptoms respond not at all or adversely to ARBs

> talk about them less, for the simple reason that we find them less

> worth talking about.

>

> Cheers,

>

> Scha

>

>

>

>

>

>