Glutathione--for Jim. was Re: Digest Number 106

[Guest guest]

Can you give a link or web address for the Wellness Pharmacy??...saw many

different references to

the stated, and did not know which one you are referring to..

Thanks for the excellent information!!!

Carol

> [Original Message]

> From: rvankonynen <richvank@...>

> <infections >

> Date: 5/13/2005 11:04:03 AM

> Subject: [infections] Glutathione--for Jim. was Re:

Digest Number 106

>

> Hi, Jim.

>

> Thanks for posting this.

>

> I hope these things you've added turn out to help you.

>

> I appreciate reading what Dr. Holtorf said about glutathione

> depletion in his patients. Dr. Cheney said that glutathione

> depletion was almost universal in his patients, also, back in 1999.

> I sent Dr. Holtorf a copy of my AACFS poster paper on glutathione in

> CFS several months ago. I also gave a copy to Dr. Larry Sharp, who

> runs the Fort Worth branch of the F & F Centers. I think it is true

> that depletion of glutathione is more common in CFS, but there are a

> couple of papers in the literature reporting on elevation of

> glutathione in some PWCs, as I discussed in my earlier message.

>

> I agree that I.V. glutathione infusions can be helpful in CFS. Many

> PWCs say they feel better for about a day or so after receiving

> one. I think it may take quite a while to restore the liver's

> production of glutathione by the use of I.V.s alone, though, so I'm

> glad to hear that you are doing the other things as well. The other

> issue with the I.V.s is the cost. At least one person has reported

> that getting the compounded 250 mg reduced glutathione suppositories

> from Wellness Pharmacy (by prescription) is more cost effective. He

> said that he can use them every day, and a month's supply cost him

> the same as one I.V. infusion.

>

> I don't believe that the liver can benefit directly from glutathione

> that is put into the blood, because it is set up to make glutathione

> from dietary amino acids that it has first access to via the portal

> vein from the gut, and to export some of this glutathione into the

> blood, rather than to make use of glutathione from the blood. Other

> organs do benefit from glutathione put directly into the blood,

> however. The half-life of glutathione in the blood plasma has been

> measured at 1.6 minutes in one human. The majority of it is taken

> out and reused by the kidneys, based on work in animals. The lungs

> are the second most prominent importer of glutathione from the

> blood. Other organs receive lesser amounts.

>

> My current view is that the combined use of one of these direct

> glutathione-into-the blood methods, such as I.V., I.M. or

> suppositories, or maybe transdermal or aerosol--nebulizer

> approaches, combined with one of the oral amino acid or protein

> methods, such as RenewPro, or NAC combined with good quality dietary

> protein may be the best approach to building glutathione. If a

> nondenatured whey protein or undenatured whey protein approach is

> used, and elevated mercury is suspected to be present, I think it is

> wise to check the blood plasma cysteine level such as by

>

> http://www.gsdl.com

>

> to make sure it is not getting too high, perhaps a couple of weeks

> into it. A few people have reported that this can be a problem.

> Cysteine is known to be a neurotoxin if it gets high enough in

> concentration, and some people's pathways for utilizing cysteine

> either to make glutathione or to be oxidized to sulfate, appear to

> be inhibited. I think that mercury is responsible, and a deficiency

> of molybdenum may also be involved in some cases. If a person with

> such inhibited pathways takes in a lot of cysteine, the level in the

> blood may rise too high. I encourage people to be cautious about

> this. I don't think that the methods that involve NAC, or the

> oxidized form of cysteine (cystine) as in regular commercial whey

> protein, or glutathione molecules per se will raise cysteine, but I

> think that the nondenatured or undenatured whey protein products do

> have this potential in some people.

>

> The new product Lipoceutical Glutathione from Wellness Health may be

> able to accomplish the whole job of helping both the liver and the

> other organs with glutathione depletion, because it seems to have

> the potential to enter all types of cells by passing right through

> their phospholipid membranes and carrying glutathione inside. Not

> much experience has been reported yet with this product in CFS,

> though it seems to be helping people with autism, Parkinson's and

> cystic fibrosis. This approach is also fairly expensive at present.

>

> Rich

>

>

> > Rich-

> > Been following your glutathione comments with

> > interest. Does certainly seem to be at the nexus of a

> > lot of functions and has lead me to add some things

> > into my CFS/ Cpn regime, including NAC, slowly ramping

> > up undenatured whey, looking to see if there has been

> > any resulting (from glut depletion) mercury

> > accumulation, etc.

> >

> > Interestingly, just had a phone consult with Ken

> > Holtorf MD (the medical director for the

> > Fibromyalgianand Fatigue Clinics) for my daughter who

> > is also being treated for CFS and immune dysfunction.

> > When I asked him if he's found it worthwhile to do red

> > cell or other measurement of glutathione levels, he

> > said, " No, because when we did, everyone tested

> > depleted, so we stopped testing for it and just assume

> > it's the case. " They use glutathione push in a lot the

> > IV treatments he's developed.

> >

> > Jim

>

>

>

>

>

>

>

>

[Guest guest]

--- In infections , " Peg " <lanelle@h...>

wrote:

>

>

> My doctor (who does

> use glutathion in his vitamin IV's says that glutathione in the

pill,

> powder, i.e. oral ingestion, does not get absorbed or utilized. I am

> assuming that is why it is used in the IV form. Or is this a $$

> business issue?

>

> > Thank you so much

>

> Peg

Hi Peg,

A CFS patient emailed me and said that the Jarrow Reduced

Glutathione capusles, 500mg were prescribed by her doctor. She

mentioned that she tried whey protein that did not work well for her,

she knows about the gut absortion problem with capusles, but she said

the capusles work well for her, and that she still abosorbs some of

the dosage she takes.

Al