RE: Jaep -- re-post

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-----Original Message-----From: infections [mailto:infections ]On Behalf Of HodologicaSent: 14 April 2005 23:56infections Subject: [infections] Jaep -- re-post, below is 1071 (replied to by Rich in 1112). I made one otherpost mentioning heavy metals - it just said that PMID 10334427 is thefinding Cheney mentioned on superconcentration of heavy metals in theheart in idiopathic dilated cardiomyopathy. I got the full text ofthat paper and will report on it soon if I can understand it. BTW, thanks alot for turning me on to http://www.signaling-gateway.org- its rad. ===============================Those are indeed some nice tallies with your ideas - you must behaving a field day with this stuff :)I think Cheney might be interested in hearing your take. I justreviewed his stuff and I understand it better now than I did earliertoday. While he emphasizes that this is merely what he'd wager on, inthe idea he's putting forward, the heavy metal accumulation in theheart IS the lasting damage left by the cardiotropic pathogen - and Ithink he's saying that there isnt necessarily heart tissue damage inthe "normal" sense. That's what I didnt grasp earlier today.And I think he's saying that this accumulation of heavy metal in theheart is what makes the heart super sensitive to NO, because the heavymetal can interfere with SOD, thus causing the increase in superoxide,which is the rate-limiting contributer to the formation ofperoxynitrate in the presence of NO.So its cardiotropic infection (maybe) >> astronomical heavy metalconcentrations in the heart, in the absence of effective detox >>inability to avert peroxynitrate production - ?But from here I get confused. Is he hinting that peroxynitrate thendamages heart tissue progressively by oxidative cytotoxicity? Also,its unclear where the high expression of NO is coming from. Cheneyhints at iNOS as the probable source, and hints at "immune activation"due to antigen as the cause of iNOS expression - which presumablymeans theres a chronic infection (this one not necessarily verycardiotropic).And he doesnt get into the chronic infection part really at all, somaybe hes at a bit of a loss there and would be interested in tryingout in some of your ideas, Rich, at this point way up at theheadwaters of the causal stream.Personally, I had a broken mercury thermometer in my bag for probablya full week when I was living in the woods. I had only a lawn tarp tokeep the very thick mosquitos off me - so every night for a week Islept basically *sealed* into a very small space with this mercury. Ithen moved into a house and promptly spilled the same mercury from mybag onto the carpet (which is how I first discovered it). This was 3years before I even started to slowly get CFIDS and I had no medicalor biological knowledge but I knew this was bad. I ran a fan in theroom the whole rest of the summer with another window open for intake,and I did a 24h urine specimin - it was "negative" for excessive Hg,but we all know that some medical determinations are alot betterfounded than others...Anyway, I still dont see how all this gets a person swollen glands (Iknow no theory is nearly perfect so far, eg the most advanced andspeculative understanding of lyme disease leaves some VERY odd ends,but I'm just sayin').And personally I am definitely going to read the paper Cheney cited onHg in the heart, but I still think one might find serious vasculitisif some of these hearts were to be cut up, and that might be thebottom of all this. Which leads me to wonder, what did Cheney do withhis old heart? Seems a pity to toss it out - one should do somehistology on it, and a heavy metal assay! Speaking of which, if anyoneon this list dies, please have yourself mailed to my house (exceptRich, who doesnt have A-CID).