Guest guest Posted April 20, 2005 Report Share Posted April 20, 2005 Thanks , some good reading there...no time at the mo ..i'll lokk forward to reading it soon ... ] -----Original Message-----From: infections [mailto:infections ]On Behalf Of HodologicaSent: 20 April 2005 05:13infections Subject: [infections] Jaep - Ah yes, smart combo application gets significant milage out of a drugthat could easily be dismissed as too toxic to be useful. A smooth move.If bacterial persistence underlies most of our illnesses, as Ipersonally consider fairly probable, the reasons for refractoriness toabx may not be mutational resistance. Which is where the bacterium hasa mutation in the drug target molecule that prevents the drug frombinding its target, or the bacterium upregulates a membrane pump thatpumps out the drug (or downregs an intake pump), etc. Or a bacterium can just be dormant and stop taking in molecules,including drugs, from its millieu for a while (indefinitely). Matt once showed me this paper, which is also referenced by Wheldon inhis paper on MS. It may demonstrate resistance reflecting none ofthose mechanisms, but rather soemthing we just dont understand:http://circ.ahajournals.org/cgi/content/full/103/3/351I cant figure out whether that paper is saying the abx-refractory Cpninfection of monocytes is productive, or is non-productive. It seemsto possibly vaguely contradict itself on that. A non-productive"bunker" does not look like a great candidate for a place where aabx-refractory infection can draw strength. If the bacteria dontreplicate, they should slowly die out. However, this finding seems to say Cpn can *productively* infectlymphocytes, and be refractory to abx there:http://aac.asm.org/cgi/content/full/47/6/1972So like, WHY? Or more accurately, HOW the heck does this happen withCpn, and could it happen with some other organisms. No ideas come tomind. Its pretty damn weird. The Wirostko/ group visualized L-form "non-infectious uveitis"bacteria within monocytes, neutrophils, and lymphocytes (andendothelial and epithelial cells).<Jaep@L...> wrote:> Thanks , I don't grasp the mechanism either, I think & talk in> principles , I don't think many if any have an intimate knowledge ofhow the> IS works , I see the problem with mono therapy [tetracylinesprobably wont> ever fly] that's why drug combos are so much more effective ,especially> if the drugs involved work in different ways ...Take a look at thisarticle> ..its a very convincing picture on combos ..the pity is the work is not> taken up if you like ..its not adopted for further study ...its just one> more piece of information in a sea of information ...we need a good> co-ordinator...> Quote Link to comment Share on other sites More sharing options...
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